Biotechnology Applications of Nanocarbons in Plant and Algal Systems

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Publications associées (31)

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

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CAR-T cell therapy has shown remarkable success in treating hematopoietic malignancies, but its efficacy in solid tumors is limited by T cell dysfunction, including exhaustion and senescence. In this study, we designed metabolically armored CAR-T cells to ...

EPFL2023

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Colorectal cancer is the second-leading cause of cancer death worldwide. Early-stage disease can be detected with preventative medical screening and is treatable with surgical resection. Sixty-percent of patients, however, are diagnosed with advanced-stage ...

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Nanotechnology enabled modulation of T cell immunity for cancer treatment

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Recent breakthroughs in cancer immunotherapy, exemplified by immune checkpoint blockade and CAR T cell therapy, have achieved remarkable clinical success. However, the majority of cancer patients fail to respond to immunotherapy or suffer from relapse. Nan ...

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Methods and devices for cultivating coenocytic algae

Christian Ludwig, Enio Daniel Zanchetta, Eya Nicodeme

The present invention concerns methods and devices for cultivating coenocytic algae and for producing cellulose, in particular microfibrillated cellulose (MFC). In one embodiment, the algae are grown on a solid substrate immersed in liquid culture medium. ...

2023

Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes

Julien Racle, David Gfeller, Philippe Guillaume Coune, Florence Pojer, Marta Andreia Da Silva Perez, George Coukos, Kelvin Ka Ching Lau, Amédé Noredine Larabi, Alexandre Harari

CD4+T cells orchestrate the adaptive immune response against pathogens and cancer by recognizing epitopes presented on class II major histocompatibility complex (MHC-II) molecules. The high polymorphism of MHC-II genes represents an important hurdle toward ...

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Extensive programmed centriole elimination unveiled in C. elegans embryos

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Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabditis ele ...

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Engineering synthetic adhesins for biophysical investigation and rewiring of host-microbe interactions

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Host attachment is often a critical step in the onset of pathogenesis. To attach to host cells, bacteria have evolved a range of adhesins that bind to specific receptors. Some of these adhesins have been thoroughly characterized using biochemical technique ...

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Presence of algal symbionts affects denitrifying bacterial communities in the sea anemone Aiptasia coral model

Anders Meibom, Nils Rädecker, Claudia Isabella Pogoreutz

The coral-algal symbiosis is maintained by a constant and limited nitrogen availability in the holobiont. Denitrifiers, i.e., prokaryotes reducing nitrate/nitrite to dinitrogen, could contribute to maintaining the nitrogen limitation in the coral holobiont ...

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Warming may extend tree growing seasons and compensate for reduced carbon uptake during dry periods

Yann Vitasse, Charlotte Grossiord, Eugénie Isabelle Mas, Christoph Bachofen, Margaux Clara Lou Didion-Gency

Warming and drought alter plant phenology, photosynthesis and growth with important consequences for the global carbon cycle and the earth’s climate. Yet, few studies have attempted to tease apart their effects on tree phenology, particularly leaf senes ...

2022

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion

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Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FM ...

American Association for the Advancement of Science2022

The role of eosinophils in breast cancer

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Eosinophils are granulocytes and belong to the innate arm of immunity. Eosinophils can be in different basal or activation states and depending on which type of activation is applied, they exert different effector functions. These multi-functional cells ha ...

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