The Links between ALS and NF-κB

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The process of protein aggregation, central to neurodegenerative diseases like Huntington’s, is challenging to study due to its unpredictable nature and relatively rapid kinetics. Understanding its biomechanics is crucial for unraveling its role in disease ...

A slow decline in the autophagy-lysosomal pathway is a hallmark of the normal aging brain. Yet, an acceleration of this cellular function may propel neurodegenerative events. In fact, mutations in genes associated with the autophagy-lysosomal pathway can l ...

Load-bearing systems in buildings, significant in material use and embodied greenhouse gas emissions (EGHGE), have lacked detailed analysis on their environmental and functional relationships over time and space. This study evaluates the environmental impa ...

Multiple System Atrophy (MSA) is an aggressive neurodegenerative disorder characterized by the formation of Glial Cytoplasmic Inclusions (GCI) containing alpha-synuclein (aSyn) fibrils in brain tissue. The fundamental causes for many neurodegenerative dise ...

The dynamic landscape of sustainable smart cities is witnessing a signi ficant transformation due to the integration of emerging computational technologies and innovative models. These advancements are reshaping data -driven planning strategies, practices, ...

Glacier-fed streams are the cold, ultra-oligotrophic, and unstable streams that are fed by glacial meltwater. Despite these extreme conditions, they harbour a diverse and abundant microbial diversity that develops into biofilms, covering the boulders and s ...

Zoning reform is a crucial tool for cities to adapt to contemporary challenges. However, its implementation remains challenging. Property owners, with a vested interest in the value of their neighborhoods, are sensitive to local developments and the potent ...

In this paper, we present a new parameterization and optimization procedure for minimizing the weight of ribbed plates. The primary goal is to reduce embodied CO2 in concrete floors as part of the effort to diminish the carbon footprint of the construction ...

Receptor-interacting protein 1 (RIP1, RIPK1) is a critical mediator of multiple signaling pathways that promote inflammatory responses and cell death. The kinase activity of RIP1 contributes to the pathogenesis of a number of inflammatory and neurodegenera ...

The growing global obesity issue emphasizes the importance of understanding its health implications. Previous research has identified consistent alterations in gray matter (GM) volume in connection with obesity. Given the various implications of distinct f ...

In integrated ecosystem assessment projects, scenarios provide alternative images of environmental futures as orientation knowledge for opinion-forming and decision-making. Participatory scenario frameworks provide the methodological basis for ecosystem sc ...

Cells cope with and adapt to ever-changing environmental conditions. Sophisticated regulatory networks allow cells to adjust to these fluctuating environments. One such archetypal system is the Saccharomyces cerevisiae Pho regulon. When external inorganic ...

An ordinary electric drill was integrated into a context-aware augmented reality (AR) framework to assist in timber-drilling tasks. This study is a preliminary evaluation to detail technical challenges, potential bottlenecks, and accuracy of the proposed o ...

Calling for increased action on climate change, Fridays for Future (FFF) quickly gained momentum around the world and became highly visible through strikes and protests in more than 150 countries. Considering its scale and magnitude, questions about the im ...

Food consumption is among the activities with the most significant environmental impacts, and furthermore contributes to rising health costs. We explored the factors that foster or hinder healthy and sustainable eating in Switzerland. Based on an online ho ...

Cell-sized giant unilamellar vesicles (GUVs) are an ideal tool for understanding lipid membrane structure and properties. Label-free spatiotemporal images of their membrane potential and structure would greatly aid the quantitative understanding of membran ...

Muscle stem cells (MuSCs) are the primary source of myogenic progenitors during muscle repair and are essential for the long-term regenerative capacity of skeletal muscle. Following myofiber injury, MuSCs transition from a quiescent to an activated state, ...

Non-noble metal catalysts (NNMCs) hold the potential to replace the expensive Pt-based materials currently used to speed up the oxygen reduction reaction (ORR) in proton exchange membrane fuel cell (PEMFC) cathodes, but they feature poor durability that in ...

Retaining structures above groundwater level support soils that are usually in a state of partial saturation and subject to the actions of atmospheric agents. The current design approach considers the possible extremes of soil conditions - either totally d ...

Acinetobacter baumannii is a dangerous nosocomial pathogen, especially due to its ability to rapidly acquire new genetic traits, including antibiotic resistance genes (ARG). In A. baumannii, natural competence for transformation, one of the primary modes o ...

The Links between ALS and NF-κB

Chattez avec Graph Search

Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging

A novel allosteric GCase modulator prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models

Multiscale Spatiotemporal Characterization of Embodied Environmental Performance of Building Structures in Geneva from 1850 to 2018

Disentangling Multiple System Atrophy - Structural insights from alpha-synuclein fibrils and tissue pathology

The synergistic interplay of artificial intelligence and digital twin in environmentally planning sustainable smart cities: A comprehensive systematic review

The microbial genomics of glacier-fed streams: adaptations to an extreme ecosystem

Spatial Modeling for Building Design Evaluation: from Visual Landscape Quality Assessment to Devaluation Risk Estimation

Mesh-based topology, shape and sizing optimization of ribbed plates

RIP1 inhibition protects retinal ganglion cells in glaucoma models of ocular injury

The interplay between white adipose tissue, adipokines, and structural gray matter changes

Ecosystem Scenarios as Environmental Futures - Implications for Participatory Framework Designs Integrating Social Capital Formation and Natural Capital Preservation

Perfect adaptation achieved by transport limitations governs the inorganic phosphate response in S. cerevisiae

Augmented-reality-assisted timber drilling with smart retrofitted tools

Perceived impacts of the Fridays for Future climate movement on environmental concern and behaviour in Switzerland

Drivers and Barriers Toward Healthy and Environmentally Sustainable Eating in Switzerland: Linking Impacts to Intentions and Practices

High throughput wide field second harmonic imaging of giant unilamellar vesicles

Molecular Regulation of Muscle Stem Cell Fate during Skeletal Muscle Regeneration and Aging

Decoupling the Contributions of Different Instability Mechanisms to the PEMFC Performance Decay of Non-noble Metal O2-Reduction Catalysts

Life cycle environmental assessment of retaining walls in unsaturated soils

DNA modifications impact natural transformation of Acinetobacter baumannii