FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

The process of protein aggregation, central to neurodegenerative diseases like Huntington’s, is challenging to study due to its unpredictable nature and relatively rapid kinetics. Understanding its biomechanics is crucial for unraveling its role in disease ...

A slow decline in the autophagy-lysosomal pathway is a hallmark of the normal aging brain. Yet, an acceleration of this cellular function may propel neurodegenerative events. In fact, mutations in genes associated with the autophagy-lysosomal pathway can l ...

Multiple System Atrophy (MSA) is an aggressive neurodegenerative disorder characterized by the formation of Glial Cytoplasmic Inclusions (GCI) containing alpha-synuclein (aSyn) fibrils in brain tissue. The fundamental causes for many neurodegenerative dise ...

Preventing the misfolding or aggregation of TDP-43 is the most actively pursued disease-modifying strategy to treat amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. In our work, we provide proof of concept that native state stabili ...

The early branching eukaryote Naegleria gruberi can transform transiently from an amoeboid life form lacking centrioles and flagella to a flagellate life form where these elements are present, followed by reversion to the amoeboid state. The mechanisms imp ...

Abnormal tau protein aggregates constitute a hallmark of Alzheimer's disease. The mechanisms underlying the initiation of tau aggregation in sporadic neurodegeneration remain unclear. Here we investigate whether a non-human prion can seed tau aggregation. ...

Elastic interfaces display scale-invariant geometrical fluctuations at sufficiently large lengthscales. Their asymptotic static roughness then follows a power-law behavior, whose associated exponent provides a robust signature of the universality class to ...

Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify defici ...

Liquid-liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlying the formation of membrane-less organelles. Such biomolecular condensates have various biological functions and have been linked to disease. The protein F ...

Professionals in the building design and operation fields typically look at standards and guidelines as a reliable source of information and guidance with regard to procedural, contractual, and legal scope and requirements that are relevant to accountabili ...

Motivated by the goal of designing interventions for softening polarized opinions on the Web, and building on results from psychology, we hypothesized that people would be moved more easily towards opposing opinions when the latter were voiced by a celebri ...

Exposure to daylight has much to offer and should be optimised to maximise its potential. In order to harvest its benefits, any visual discomfort from daylight should be anticipated and minimised. Hence, there is the need to predict discomfort from dayligh ...

Preventing the misfolding or aggregation of transactive response DNA binding protein with 43 kDa (TDP-43) is the most actively pursued disease-modifying strategy to treat amyotrophic lateral sclerosis and other neurodegenerative diseases. In this work, we ...

Genotype imputation is a fundamental step in genomic data analysis, where missing variant genotypes are predicted using the existing genotypes of nearby "tag"variants. Although researchers can outsource genotype imputation, privacy concerns may prohibit ge ...

This thesis consists of four Chapters unified by a singular theme â how do we develop disease models that faithfully reproduce the pathology seen in patients suffering from neurodegenerative disorders associated with the Tau protein, such as Alzheimerâ ...

Peptide-based hydrogels are promising biocompatible materials for wound healing, drug delivery, and tissue engineering applications. The physical properties of these nanostructured materials depend strongly on the morphology of the gel network. However, th ...

Whereas electron-phonon scattering relaxes the electron's momentum in metals, a perpetual exchange of momentum between phonons and electrons may conserve total momentum and lead to a coupled electron-phonon liquid. Such a phase of matter could be a platfor ...

Perception depends not only on the current sensory input but also on the preceding history of stimuli. In serial dependence (SD), for example, the orientation of a Gabor patch is mistakenly reported as more similar to previous trials than it actually is. T ...

Minimax-fair machine learning minimizes the error for the worst-off group. However, empirical evidence suggests that when sophisticated models are trained with standard empirical risk minimization (ERM), they often have the same performance on the worst-of ...

By analogy to heat and mass transfer film theory, a general approach is introduced for determining hyperpolarization transfer rates between dilute electron spins and a surrounding nuclear ensemble. These analyses provide new quantitative relationships for ...

FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade

Chattez avec Graph Search

Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging

A novel allosteric GCase modulator prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models

Disentangling Multiple System Atrophy - Structural insights from alpha-synuclein fibrils and tissue pathology

Targeting TDP-43 Proteinopathies in Neurodegeneration by its Native-State Stabilization

Mechanisms of axoneme and centriole elimination in Naegleria gruberi

Trans‐seeding of Alzheimer‐related tau protein by a yeast prion

Microscopic interplay of temperature and disorder of a one-dimensional elastic interface

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation

Thermal Conditions in Indoor Environments: Exploring the Reasoning behind Standard-Based Recommendations

Interventions for Softening Can Lead to Hardening of Opinions: Evidence from a Randomized Controlled Trial

Is there a difference in how people from different socio-environmental contexts perceive discomfort due to glare from daylight?

Effective Inhibition of TDP-43 Aggregation by Native State Stabilization

Ultrafast homomorphic encryption models enable secure outsourcing of genotype imputation

Deconstructing and Reconstructing the Complexity of Tau pathology

Fast Self-Assembly Dynamics of a beta-Sheet Peptide Soft Material

Evidence of a coupled electron-phonon liquid in NbGe2

Serial dependence does not originate from low-level visual processing

When do Minimax-fair Learning and Empirical Risk Minimization Coincide?

Scaling analyses for hyperpolarization transfer across a spin-diffusion barrier and into bulk solid media