Publications associées à Medium-to long-term frequency stability of high-performance CW double-resonance Rb standard

Structure-preserving approaches and data-driven closure modeling for model order reduction

In this thesis, we propose model order reduction techniques for high-dimensional PDEs that preserve structures of the original problems and develop a closure modeling framework leveraging the Mori-Zwanzig formalism and recurrent neural networks. Since high ...

EPFL2022

Continual Test-Time Domain Adaptation

Qin Wang, Olga Fink

Test-time domain adaptation aims to adapt a source pretrained model to a target domain without using any source data. Existing works mainly consider the case where the target domain is static. However, real-world machine perception systems are running in n ...

IEEE COMPUTER SOC2022

Pathological substrate of memory impairment in multiple system atrophy

Hilal Lashuel, Melek Firat Altay

Aims: Synaptic dysfunction in Parkinson's disease is caused by propagation of pathogenic alpha-synuclein between neurons. Previously, in multiple system atrophy (MSA), pathologically characterised by ectopic deposition of abnormal alpha-synuclein predomina ...

WILEY2022

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Maria del Carmen Sandi Perez, Ioannis Zalachoras, Sara Ramirez Flores

Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and ...

Cell Press2022

Learning Decoupled Representations for Human Pose Forecasting

Alexandre Massoud Alahi, Yuejiang Liu, Behnam Parsaeifard, Saeed Saadatnejad, Taylor Ferdinand Mordan

Human pose forecasting involves complex spatiotemporal interactions between body parts (e.g., arms, legs, spine). State-of-the-art approaches use Long Short-Term Memories (LSTMs) or Variational AutoEncoders (VAEs) to solve the problem. Yet, they do not eff ...

IEEE2021

Video Prediction Recalling Long-term Motion Context via Memory Alignment Learning

Hakgu Kim

Our work addresses long-term motion context issues for predicting future frames. To predict the future precisely, it is required to capture which long-term motion context (e.g., walking or running) the input motion (e.g., leg movement) belongs to. The bott ...

IEEE COMPUTER SOC2021

Agency conflicts and short- versus long-termism in corporate policies

Erwan Morellec

We build a dynamic agency model in which the agent controls both current earnings via short-term investment and firm growth via long-term investment. Under the optimal contract, agency conflicts can induce short- and long-term investment levels beyond firs ...

ELSEVIER SCIENCE SA2020

Mixed-Precision Deep Learning Based on Computational Memory

Irem Boybat Kara, Abu Sebastian, Evangelos Eleftheriou

Deep neural networks (DNNs) have revolutionized the field of artificial intelligence and have achieved unprecedented success in cognitive tasks such as image and speech recognition. Training of large DNNs, however, is computationally intensive and this has ...

FRONTIERS MEDIA SA2020

Constitutive differences in glucocorticoid responsiveness are related to divergent spatial information processing abilities

Maria del Carmen Sandi Perez, Eleni Vasilaki, Damien Sébastien Huzard, Simone Astori

The stress response facilitates survival through adaptation and is intimately related to cognitive processes. The Morris water maze task probes spatial learning and memory in rodents and glucocorticoids (i.e. corticosterone (CORT) in rats) have been sugges ...

2020

The effect of frontoparietal paired associative stimulation on decision-making and working memory

Traian Popa

Previous single-site neurostimulation experiments have unsuccessfully attempted to shift decision-making away from habitual control, a fast, inflexible cognitive strategy, towards goal-directed control, a flexible, though computationally expensive strategy ...

2019

Towards Advanced Fusion Gyrotrons: 2018 Update on Activities within EUROfusion

Stefano Alberti, Minh Quang Tran, Ioannis Pagonakis, Konstantinos Avramidis, Martin Schmid

During the ongoing pre-concept phase (2014 - 2020) for a possible future European DEMOnstration Fusion Power Plant (DEMO) the activities within EUROfusion WP HCD EC Gyrotron R&D and Advanced Developments are focusing on options for near-term solutions, and ...

E D P SCIENCES2019

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Rolf Gruetter, João Miguel das Neves Duarte

Diabetes affects the morphology and plasticity of the hippocampus, and leads to learning and memory deficits. Caffeine has been proposed to prevent memory impairment upon multiple chronic disorders with neurological involvement. We tested whether long-term ...

2019

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Meltem Weger

Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social ...

2018

A New Conceptualization of Human Visual Sensory-Memory

Michael Herzog

Memory is an essential component of cognition and disorders of memory have significant individual and societal costs. The Atkinson-Shiffrin "modal model" forms the foundation of our understanding of human memory. It consists of three stores: Sensory Memory ...

Frontiers Media2016

Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine

Jean-Luc Martin, Pierre Magistretti, Benjamin Boutrel, Benjamin Boury-Jamot, Anthony Carrard

A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memo ...

Nature Publishing Group2015

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron-Astrocyte Metabolic Coupling in Long Term Memory

Sylvain Eric Lengacher, Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Monika Tadi

We examined the expression of genes related to brain energy metabolism and particularly those encoding glia (astrocyte)-specific functions in the dorsal hippocampus subsequent to learning. Context-dependent avoidance behavior was tested in mice using the s ...

Public Library of Science2015

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Pierre Magistretti, Pascal Jourdain, Igor Allaman, Jean-Marie Petit, Gabriele Grenningloh, Evelyne Ruchti, Jiangyan Yang

L-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism invo ...

National Academy of Sciences2014

Elucidating the role of neuron-astrocyte metabolic coupling in learning and memory : molecular, genetic and behavioural approaches

Monika Tadi

The brain has very high energy demands that are mainly met by the circulating blood glucose to ensure its proper functioning. Thus, it is not surprising that though the human brain weighs only 2- 3% of the body weight, it consumes approximately 25% of tota ...

EPFL2013

Astrocyte-neuron lactate transport is required for long-term memory formation

We report that, in the rat hippocampus, learning leads to a significant increase in extracellular lactate levels that derive from glycogen, an energy reserve selectively localized in astrocytes. Astrocytic glycogen breakdown and lactate release are essenti ...

2011

Neurobiological Mechanisms Involved in the Establishment and Maintenance of Dominance Hierarchies and its Modulation by Stress in Rats

Maria del Carmen Sandi Perez, Marjan Timmer

Stress can have a strong and long lasting effect on the establishment and maintenance of dominance hierarchies in rats. When two rats of a pair have not been stressed (non-stressed pair) before a first social encounter, they establish a dominance hierarchy ...

EPFL2011