Leukocyte Count and New-onset Diabetes Mellitus in People with Hiv: a Longitudinal Study

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We investigate the mid-infrared chiroptical response of plasmonic nanostructures based on Al-doped ZnO and layers of an aqueous solution of Ladarixin, a chiral pharmaceutical currently under clinical trial for the treatment of type 1 diabetes. We explore t ...

Type 1 and type 2 diabetic patients experience alterations in the Central Nervous System, leading to cognitive deficits. Cognitive deficits have been also observed in animal models of diabetes such as impaired sensory perception, as well as deficits in wor ...

Particle dampers have received considerable attention in recent years as a novel damping technique. However, due to its high degree of nonlinearity, no mature damping model has been constructed. This article proposes an equivalent raft model that takes int ...

Over the past decades, several antiviral drugs have been developed to treat a range of infections. Yet the number of treatable viral infections is still limited, and resistance to current drug regimens is an ever-growing problem. Therefore, additional stra ...

We exploit differences across U.S. states' exposure to trade to study the effects of changes in the exchange rate on economic activity. Across states, trade-weighted exchange rate depreciations are associated with increased state exports, reduced state une ...

The human pathogen Vibrio cholerae serves as a model organism for many important processes ranging from pathogenesis to natural transformation, which has been extensively studied in this bacterium. Previous work has deciphered important regulatory circuits ...

A popular strategy for overcoming the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteoly ...

Common single-nucleotide variation in the host accounts for 25% of the variability in the plasma levels of HIV during the clinical latency stage (viral load set point). However, the role of rare variants and copy number variants remains relatively unexplor ...

Diabetes Type 1 is a metabolic disease which results in a lack of insulin production, causing high glucose levels in the blood. It is crucial for diabetic patients to balance this glucose level, and they depend on external substances to do so. In order to ...

Background: Known antiretroviral restriction factors are encoded by genes that are under positive selection pressure, induced during HIV-1 infection, up-regulated by interferons, and/or interact with viral proteins. To identify potential novel restriction ...

Background: Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential ro ...

Diabetes is characterized by hyperglycemia that can result from the loss of pancreatic insulin secreting β-cells in the islets of Langerhans. We analyzed ex vivo the entire gastric and duodenal lobes of a murine pancreas using extended-focus Optical Cohere ...

Critical infrastructures are receiving a great deal of attention, due, on the one hand, to the major malfunctions to which they are subject and their potential as targets of malicious intent on the other. Economic and political impacts are studied; increas ...

Development of new drugs to treat tuberculosis (TB) faces even more constraints than the development of therapeutic agents for other diseases. This is due, in part, to intrinsic properties of the tubercle bacillus, such as its slow growth, phenotypic drug ...

Leukocyte Count and New-onset Diabetes Mellitus in People with Hiv: a Longitudinal Study

Chattez avec Graph Search

Vibrational circular dichroism of plasmonic nanostructures embedding chiral drugs

Impairment of synaptic plasticity in the primary somatosensory cortex in a model of diabetic mice

Evaluation of a clinical artificial intelligence companion for therapeutic decision making in type 2 diabetes management: a retrospective analysis

A simplified modeling method for multi-particle damper: Validation and application in energy dissipation analysis

Advances in the development of entry inhibitors for sialic-acid-targeting viruses

Regional Effects of Exchange Rate Fluctuations

Comparison of chitin‐induced natural transformation in pandemic Vibrio cholerae O1 El Tor strains

Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity

No Evidence for Association of beta-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS

Semantic representation and processing of hypoglycemic events derived from wearable sensor data

Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses

Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort

Diabetes imaging — quantitative assessment of islets of Langerhans distribution in murine pancreas using extended-focus optical coherence microscopy

Connected at any cost? The vulnerability of critical infrastructures and crisis management

Rising standards for tuberculosis drug development