Total asymmetric synthesis of glycomimetics and polypropionates of biological interest

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The development of a sequential copper-catalyzed oxy-alkynylation/intramolecular [4+2] cycloaddition of allenes and arenes was investigated at first. This one-pot protocol allowed the construction of complex polycylic architectures with high efficiency fro ...

Organic radicals are highly active species that can undergo various transformations. Electrochemistry and photochemistry are efficient methods for the generation of these species of high energy, through single electron transfer processes under mild conditi ...

The art of natural product total synthesis is closely associated with two major determinants: the development/application of novel chemical reactions and the innovation in strategic use of classic organic reactions. While purposely seeking/applying a new s ...

We investigate phase separation in a chiral fluid, made of spinning ferromagnetic colloids that interact both via hydrodynamic and dipolar forces and collectively organize into separated circulating clusters. We show that, at high spinning frequency, hydro ...

Chiral auxiliaries and asymmetric catalysis are the workhorses of enantioselective transformations, but they still remain limited in terms of either efficiency or generality. Herein, we present an alternative strategy for controlling the stereoselectivity ...

This review presents an account of the palladium-catalyzed functionalizations of alkenes and alkynes developed at the Laboratory of Catalysis and Organic Synthesis (LCSO). Starting from the intramolecular oxy- and aminoalkynylation of alkenes, tethered met ...

The creation of new chiral ligands capable of providing high stereocontrol in metal-catalyzed reactions is crucial in modern organic synthesis. The production of bioactive molecules as single enantiomers is increasingly required, and asymmetric catalysis w ...

The development of catalytic enantioselective transformations, enabling the construction of complex molecular scaffolds from simple precursors, has been a long-standing challenge in organic synthesis. Recent achievements in transition-metal catalyzed enant ...

a-Amino ketones and 1,2-amino alcohols are important structural motifs in organic chemistry, that can be observed in natural products, pharmaceutically and bioactive compounds. For these reasons, they constitute privileged targets for the development of ne ...

This review describes the development of enantioselective methods for the ring opening of cyclopropanes. Both approaches based on the reaction of nonchiral cyclopropanes and (dynamic) kinetic resolutions and asymmetric transformations of chiral substrates ...

Twisted bilayer graphene (TBG) is a two-dimensional chiral material whose optical activity is remarkably strong for its atomic thickness. While the chiral optical properties of TBG are currently well understood, the optical activity of quantum dots (QDs) m ...

Measurements of iodic acid, sulfuric acid and methanesulfonic acid concentration in the gas phase obtained with a nitrate chemical ionization mass spectrometer (we used an APi-TOF mass spectrometer produced by Tofwerk AG coupled with a Chemical ionization ...

Chiral cyclopentadienyl (Cpx) metal complexes have empowered the developement of challenging asymmetric C(sp2)-H activation transformations. However the preparation of competent atropchiral Cpx ligands is long and tedious. Moreover the range of application ...

Total asymmetric synthesis of glycomimetics and polypropionates of biological interest

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New Vinylation and Alkynylation Strategies with Hypervalent Iodine Reagents and Diazo Compounds

Copper-catalyzed transformations of carboradicals generated by electrochemical and photochemical methods: oxidative amination and polyfluoroarylation

Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step

Arrested phase separation in chiral fluids of colloidal spinners

Enantioselective Carboetherification/Hydrogenation for the Synthesis of Amino Alcohols via a Catalytically Formed Chiral Auxiliary

Palladium-Catalyzed Functionalization of Olefins and Alkynes: From Oxyalkynylation to Tethered Dynamic Kinetic Asymmetric Transformations (DYKAT)

Chiral Cyclopentadienyl Ligands: Design, Syntheses, and Applications in Asymmetric Catalysis

Catalytic Enantioselective Functionalizations of C-H Bonds by Chiral Iridium Complexes

Palladium Catalysed Intramolecular Carbo-oxygenation of Propargylic Amines to Access 1,2-Amino Alcohols and alpha-Amino Ketones via in situ Tether Formation

Catalytic Enantioselective Ring-Opening Reactions of Cyclopropanes

Twisted Bilayer Graphene Quantum Dots for Chiral Nanophotonics

Iodic acid, sulfuric acid and methanesulfonic acid collected during the Arctic Ocean 2018 expedition

Tailoring Chiral Cyclopentadienyl Rhodium(III) Catalysts for Enantioselective Alkenyl C-H functionalizations