Inborn errors of type I interferon immunity in patients with severe acute hepatitis E

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The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at different stages ...

Torque teno virus (TTV) is considered to be an ubiquitous member of the commensal human blood virome commonly reported in mixed genotype co-infections. This study investigates the genomic diversity of TTV in blood samples from 816 febrile Tanzanian childre ...

The liver is the largest solid organ and the only one capable of using regenerative mechanisms to recover its mass fully. Although liver regeneration from acute injuries has been effective and extensively studied, chronic liver damage has adverse effects o ...

This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models of hepatic encephalopathy (HE). As d ...

Cancer cells enriched in cholesterol in their plasma membrane impair T-cell-mediated cytotoxicity, which can be augmented by stiffening the cancer cells via cholesterol depletion, as shown in mouse models of adoptive T-cell immunotherapy. Malignant transfo ...

Tumor-associated macrophages (TAMs) infiltrate both mouse and human tumors, typically in high numbers, and display complex interactions with cancer cells, endothelial cells (ECs) and other immune cells. TAMs comprise molecularly distinct subsets. Two such ...

Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Although TSLP is also produced upon viral infection in vitro, the role of TSLP i ...

Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution ...

The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrate ...

We describe herein some immunological properties of human fetal bone cells recently tested for bone tissue engineering applications. Adult mesenchymal stem cells and adult osteoblasts were included in the study for comparison. Surface markers involved in b ...

Inborn errors of type I interferon immunity in patients with severe acute hepatitis E

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Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

Inborn Errors of Type I Interferon Immunity in Patients with Severe Acute Hepatitis E

Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study

Dissecting the role of biliary epithelial cells during non-alcoholic fatty liver disease progression

2021 ISHEN guidelines on animal models of hepatic encephalopathy

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Role of microRNAs in tumor-associated macrophages

TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice

In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications