Role of Neurogenin3 in the migration of pancreatic endocrine cells

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Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Jeffrey Alan Hubbell, Chiara Cianciaruso, Edward Allen Phelps, Steinunn Baekkeskov Hanahan

Pancreatic islet β-cells are particularly susceptible to endoplasmic reticulum (ER) stress, which is implicated in β-cell dysfunction and loss during the pathogenesis of type 1 diabetes (T1D). The peripheral membrane protein GAD65 is an autoantigen in huma ...

Amer Diabetes Assoc2016

Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons

Chiara Cianciaruso, Edward Allen Phelps, Steinunn Baekkeskov Hanahan

The inhibitory neurotransmitter GABA is synthesized by the enzyme glutamic acid decarboxylase (GAD) in neurons and in pancreatic β-cells in islets of Langerhans where it functions as a paracrine and autocrine signaling molecule regulating the function of i ...

Public Library of Science2015

Autonomous and self-sustained circadian oscillators displayed in human islet cells

Michaël Unser, Christophe Bauer, Daniel Sage

Following on from the emerging importance of the pancreas circadian clock on islet function and the development of type 2 diabetes in rodent models, we aimed to examine circadian gene expression in human islets. The oscillator properties were assessed in i ...

Springer2013

Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling

Melody Swartz, Alice Anna Tomei, Mark Fleury, Carolyn Yong Pullin

CCR7 is implicated in lymph node metastasis of cancer, but its role is obscure. We report a mechanism explaining how interstitial flow caused by lymphatic drainage directs tumor cell migration by autocrine CCR7 signaling. Under static conditions, lymphatic ...

Elsevier2007