Strain-Promoted C-C Bond Cleavages of Cyclobutanes : A Molecular Complexity Generating Tool

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Publications associées (31)

Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones

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In the presence of a catalytic amount of Pd(OAc)(2) and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3(2H)-ones via a sequence of the Mannich reaction followed by chemo- and regiosele ...

AMER CHEMICAL SOC2020

Palladium Catalysed Intramolecular Carbo-oxygenation of Propargylic Amines to Access 1,2-Amino Alcohols and alpha-Amino Ketones via in situ Tether Formation

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a-Amino ketones and 1,2-amino alcohols are important structural motifs in organic chemistry, that can be observed in natural products, pharmaceutically and bioactive compounds. For these reasons, they constitute privileged targets for the development of ne ...

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Copper-Catalyzed Cyanoalkylative Aziridination of N-Sulfonyl Allylamines

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Reaction of N-arylsulfonyl allylamines with alkyl nitriles in the presence of di-tert-butyl peroxide (DTBP) and a catalytic amount of copper salt afforded homologated aziridines in 43-86% yield. A sequence involving addition of the in situ generated cyanom ...

Wiley2020

Synthesis and Structure-Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin

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A series of derivatives of the antimycobacterial natural product pyridomycin have been prepared with the C2 side chain attached to the macrocyclic core structure by a C-C single bond, in place of the synthetically more demanding enol ester double bond foun ...

AMER CHEMICAL SOC2020

Catalyst Evolution Enhances Production of Xylitol from Acetal-Stabilized Xylose

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We demonstrate a catalytic process for xylitol production based on the volatility and unique reactivity of diformylxylose (DFX), which can be produced at near theoretical yield from biomass and, contrary to xylose, can be easily purified by distillation. T ...

2020

TiO2- based ceramics, from basic science to applications

Nanomaterials and nanoparticles are nowadays used in a wide range of applications; from sunscreens, paint and food industry to catalytic processes, lighting, TV's and displays, their presence is percolating in our daily life. New applications rise every da ...

EPFL2020

Small Molecule Activation by Multimetallic Uranium Complexes

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The development of new processes for the selective and sustainable transformation of abundant small molecules constitutes one of the major research areas in inorganic and organometallic chemistry. These molecules as CO2, CO, N2 and H2 are abundant reservoi ...

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Nickel-Catalyzed Regioselective Hydroalkylation and Hydroarylation of Alkenyl Boronic Esters

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Metal hydride catalyzed hydrocarbonation reactions of alkenes are an efficient approach to construct new carbon-carbon bonds from readily available alkenes. However, the regioselectivity of hydrocarbonation remains challenging to be controlled. In nickel h ...

Wiley-VCH Verlag GmbH2019

Recent progress in the development of organometallics for the treatment of cancer

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From their early successes in medicine, organometallic compounds continue to attract interest as potential chemotherapeutics to treat a range of diseases. Here, we show from recent literature selected largely from the last two years that organometallics of ...

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Catalytic Upgrading of Biomass-Derived Carboxylic Acids to Fuels and Chemicals

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Our reliance on fossil fuels, which is unsustainable due to dwindling reserves, has led to various environmental issues. Lignocellulosic biomass could serve as a renewable source of carbon and energy for the production of fuels and chemicals. While several ...

EPFL2019

Pivotal Role of the Basic Character of Organic and Salt Catalysts in C-N Bond Forming Reactions of Amines with CO2

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Organocatalysts promote a range of C-N bond forming reactions of amines with CO2. Herein, we review these reactions and attempt to identify the unifying features of the catalysts that allows them to promote a multitude of seemingly unrelated reactions. Ana ...

Wiley-VCH Verlag GmbH2020

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