Emerging roles of lymphatic endothelium in regulating adaptive immunity

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Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses fighting cancer; however, long-term complete remission remains uncommon1,2. A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1 ...

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Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

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Cell-cell communication is fundamental for immune balance. Multivalent interactions of surface receptors at immune interfaces drive specific communication, with stimulatory and inhibitory signals guiding the immune outcome. Notably, the valency, affinity, ...

Cancer immunotherapy has become an attractive strategy among different therapeutic modalities over the past few years and has showed great success in the clinic. However, there are many outstanding challenges hindering the current immunotherapies. In my Ph ...

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The early branching eukaryote Naegleria gruberi can transform transiently from an amoeboid life form lacking centrioles and flagella to a flagellate life form where these elements are present, followed by reversion to the amoeboid state. The mechanisms imp ...

Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their t ...

Emerging roles of lymphatic endothelium in regulating adaptive immunity

Chattez avec Graph Search

Human alveolar lining fl uid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

Distinct ultrastructural phenotypes of glial and neuronal alpha-synuclein inclusions in multiple system atrophy

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Bioengineering functional organoid models across scales

The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer

Photo-doping of spiro-OMeTAD for highly stable and efficient perovskite solar cells

High-throughput parallel testing of ten photoelectrochemical cells for water splitting: case study on the effects of temperature in hematite photoanodes

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Unlocking Hidden Potential: Exploring the Complexities of Signaling in Immune Cell Activation to Optimize CAR Therapy

On the prediction of the induced damage by the start-up sequence of Francis turbines: On operational resilience framework

Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface

Engineering Innate and Adaptive Immunity for Enhanced Cancer Immunotherapy

Involvement of prelimbic cortex neurons and related circuits in the acquisition of a cooperative learning by pairs of rats

Mechanisms of axoneme and centriole elimination in Naegleria gruberi

Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis