Publications associées à Nitrogen-14 NMR Spectroscopy using Residual Dipolar Splittings in Solids

Publications associées (29)

Structural basis of BAK sequestration by MCL-1 in apoptosis

Apoptosis controls cell fate, ensuring tissue homeostasis and promoting disease when dysregulated. The rate-limiting step in apoptosis is mitochondrial poration by the effector B cell lymphoma 2 (BCL-2) family proteins BAK and BAX, which are activated by i ...

2025

Two-dimensional Pure Isotropic Proton Solid State NMR

Manuel Cordova, David Lyndon Emsley, Pinelopi Moutzouri, Bruno Simões de Almeida, Daria Torodii

One key bottleneck of solid-state NMR spectroscopy is that H-1 NMR spectra of organic solids are often very broad due to the presence of a strong network of dipolar couplings. We have recently suggested a new approach to tackle this problem. More specifica ...

Wiley-VCH Verlag GmbH2023

Single Chip Dynamic Nuclear Polarization Microsystems

Nergiz Sahin Solmaz

Nuclear magnetic resonance (NMR) methods are powerful tools employed in many fields, including physics, chemistry, material science, biology, and medicine. The use of NMR methodologies in an even wider range of applications is often hindered by the relativ ...

EPFL2023

Understanding unconventional magnetic order in a candidate axion insulator by resonant elastic x-ray scattering

Frédéric Mila, Henrik Moodysson Rønnow, Jian Rui Soh

Magnetic topological insulators and semimetals are a class of crystalline solids whose properties are strongly influenced by the coupling between non-trivial electronic topology and magnetic spin configurations. Such materials can host exotic electromagnet ...

Nature Portfolio2023

Lower glutamate and GABA levels in auditory cortex of tinnitus patients: a 2D-JPRESS MR spectroscopy study

Thorsten Kleinjung, Patrick Karl Alois Neff

We performed magnetic resonance spectroscopy (MRS) on healthy individuals with tinnitus and no hearing loss (n = 16) vs. a matched control group (n = 17) to further elucidate the role of excitatory and inhibitory neurotransmitters in tinnitus. Two-dimensio ...

Nature Research2022

Solid-state NMR spectroscopy

David Lyndon Emsley

Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This Primer summarizes the basic principles of NMR spectroscopy as applied to the ...

SPRINGERNATURE2021

A Low Power 35 GHz HEMT Oscillator for Electron Spin Resonance Spectroscopy

Giovanni Boero, Alessandro Valentino Matheoud, Nergiz Sahin Solmaz

This paper presents a low power microwave oscillator designed as sensor for electron spin resonance (ESR) spectroscopy. Low power consumption is necessary for low temperature operation. Additionally, lower power consumption allows for a lower microwave mag ...

IEEE2021

Relationship between depression, prefrontal creatine and grey matter volume

Elenor Morgenroth

Background: Depression and low mood are leading contributors to disability worldwide. Research indicates that clinical depression may be associated with low creatine concentrations in the brain and low prefrontal grey matter volume. Because subclinical dep ...

SAGE PUBLICATIONS LTD2021

Methylammonium Triiodide for Defect Engineering of High-Efficiency Perovskite Solar Cells

Michael Graetzel, Jacques-Edouard Moser, Shaik Mohammed Zakeeruddin, Mounir Driss Mensi, Ursula Röthlisberger, Ulf Anders Hagfeldt, Thomas Paul Baumeler, Linfeng Pan, Paramvir Ahlawat, Claudia Esther Avalos, Essa Awadh R Alharbi, Pascal Alexander Schouwink, George Cameron Fish, Mathias Dankl, Bowen Yang, Felix Thomas Eickemeyer, Viktor Skorjanc, Anurag Krishna, Olivier Ouellette, Lukas Pfeifer

The defects present in metal halide perovskite are deleterious to both the performance and stability of photovoltaic devices. Consequently, there is an intense focus on developing defect mitigation strategies. Herein we report a facile strategy that employ ...

2021

Dynamic Nuclear Polarization Enhancement of 200 at 21.15 T Enabled by 65 kHz Magic Angle Spinning

David Lyndon Emsley, Gabriele Stevanato, Snaedis Björgvinsdóttir, Yu Rao, Pierrick Berruyer, Andrea Bertarello

Solid-state nuclear magnetic resonance under magic angle spinning (MAS) enhanced with dynamic nuclear polarization (DNP) is a powerful approach to characterize many important classes of materials, allowing access to previously inaccessible structural and d ...

2020

Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies

Marc Anthony Caporini, David Lyndon Emsley

We report dynamic nuclear polarization (DNP)-enhanced magic-angle spinning (MAS) NMR spectroscopy in viral capsids from HIV-1 and bacteriophage AP205. Viruses regulate their life cycles and infectivity through modulation of their structures and dynamics. W ...

2019

New Approaches to NMR Crystallography

Federico Maria Paruzzo

The first full protocol for nuclear magnetic resonance (NMR) crystallography (NMRX) using chemical shifts was developed a decade ago, and it combines experimental isotropic chemical shifts with crystal structure prediction (CSP) and with the calculation of ...

EPFL2019

Exponential decay of the resonance error in numerical homogenization via parabolic and elliptic cell problems

Assyr Abdulle, Edoardo Paganoni, Doghonay Arjmand

This paper presents two new approaches for finding the homogenized coefficients of multiscale elliptic PDEs. Standard approaches for computing the homogenized coefficients sufer from the so-called resonance error, originating from a mismatch between the tr ...

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER2019

Advanced Computational Methods for NMR Crystallography

Albert Hofstetter

Knowledge of the atomic-level structure is key to understanding and predicting properties of materials. X-ray diffraction (XRD) is the methods of choice for structures containing well-defined long-range order. However, many materials contain various degree ...

EPFL2019

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

Arthur César Pinon, David Lyndon Emsley, Aaron James Rossini, Jasmine Viger-Gravel

Here, we show how dynamic nuclear polarization (DNP) NMR spectroscopy experiments permit the atomic level structural characterization of loaded and empty lipid nanoparticles (LNPs). The LNPs used here were synthesized by the microfluidic mixing technique a ...

2018

Transportable hyperpolarized metabolites

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Basile Vuichoud, Xiao Ji, David Lyndon Emsley, Aaron James Rossini

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

Diagnostic approaches to predict persistent post-traumatic symptoms after mild traumatic brain injury - a literature review

Jean-Philippe Thiran, Alessandro Daducci

Mild traumatic brain injury (mTBI) is one of the most frequently diagnosed neurological disorders in emergency departments. Although there are established recommendations for the diagnosis and treatment in the acute stage, there is an on-going debate in wh ...

Taylor & Francis Ltd2016

Quantum critical scaling for a Heisenberg spin-1/2 chain around saturation

Henrik Moodysson Rønnow, Mingee Chung

We demonstrate quantum critical scaling for an S = 1/2 Heisenberg antiferromagnetic chain compound Cu(C4H4N2)(NO3)(2) in a magnetic field around saturation, by analyzing previously reported magnetization [Y. Kono et al., Phys. Rev. Lett. 114, 037202 (2015) ...

American Physical Society2015

Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides

Rudolf Hovius, Christian Heinis, Florence Pojer, Shiyu Chen, Ranganath Gopalakrishnan

The disulfide bonds that form between two cysteine residues are important in defining and rigidifying the structures of proteins and peptides. In polypeptides containing multiple cysteine residues, disulfide isomerization can lead to multiple products with ...

Nature Publishing Group2014

Synthesis, characterization and in vitro anticancer activity of highly cytotoxic trithiolato diruthenium complexes of the type [(eta(6)-p-(MeC6H4Pr)-Pr-i)(2)Ru-2(mu(2)-SR1)(2)(mu(2)-SR2)](+) containing different thiolato bridges

Paul Joseph Dyson, Catherine Marie Amélie Clavel

A series of cationic dinuclear p-cymene ruthenium complexes containing three thiolato bridges with different substituents at the sulfur atoms, (eta(6)-p-(MeC6H4Pr)-Pr-i)(2)Ru-2(mu(2)-SR1)(2)(mu(2)-SR2) (R-1 = CH2Ph, R-2 = Ph: 4; R-1 = CH2Ph, R-2 = p-( ...

Elsevier2013