Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

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It is well-established that symptomatic cancers evade immune destruction by coalescing tumor microenvironments to suppress adaptive immunity. Additionally, mouse models of cervical and other cancers have revealed a capability of tumors to systemically indu ...

Once contact with a pathogen has occurred, it might be too late for the immune system to react. Here, we asked whether anticipatory neural responses might sense potential infections and signal to the immune system, priming it for a response. We show that p ...

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Nowadays, Liquid Composite Molding techniques are often used to manufacture high quality fiber reinforced composite parts at a relatively low cost. These involve an infiltration process, in which a liquid resin is forced to ingress into a dry fibrous porou ...

A unified numerical framework is presented for the modelling of multiphasic viscoelastic and elastic flows. The rheologies considered range from incompressible Newtonian or Oldroyd-B viscoelastic fluids to Neo-Hookean elastic solids. The model is formulate ...

In impermeable media, a hydraulic fracture can continue to expand even without additional fluid injection if its volume exceeds the limiting volume of a hydrostatically loaded radial fracture. This limit depends on the mechanical properties of the surround ...

Fluidic systems enable actuation in various applications, such as automotive, medical, and industrial robotics. Miniaturized valves constitute a fundamental controlling element of modern fluidic systems, intriguing the interest of many researchers. This le ...

In this paper we demonstrate ultra-high sensitivity silicon nanowires pH and protein sensing on the same Silicon nanowire array platform by using a constant current method and monitoring the drain voltage as function of analyte concentration. The injected ...

We consider fluid flows, governed by the Navier-Stokes equations, subject to a steady symmetry-breaking bifurcation and forced by a weak noise acting on a slow timescale. By generalizing the multiple-scale weakly nonlinear expansion technique employed in t ...

The early branching eukaryote Naegleria gruberi can transform transiently from an amoeboid life form lacking centrioles and flagella to a flagellate life form where these elements are present, followed by reversion to the amoeboid state. The mechanisms imp ...

Medical research and technological advancements are heading towards tailored healthcare approaches that prioritize individual needs, allowing for more accurate diagnoses, more effective treatments, and better patient outcomes overall. One such approach is ...

We seek to address how air entrapment mechanisms during infiltration are influenced by the wetting characteristics of the fluid and the pore network formed by the reinforcement. To this end, we evaluated the behavior of two model fluids with different surf ...

The thesis is dedicated to the study of two main partial differential equations (PDEs) in fluid dynamics: the Navier-Stokes equations, which describe the motion of incompressible fluids, and the transport equation with divergence-free velocity fields, whic ...

Cells have evolved endocytic pathways to internalize different molecules, to regulate intra-cellular communication and their interaction with external environment. Pathogens have co-evolved with cells to exploit these processes for infections. In particula ...

The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at different stages ...

The present relates to a system for automated cell culture, the system comprising an inflow module, a cell culture plate and an outflow module, said inflow module being in fluid connection with the outflow module via the cell culture plate, the inflow modu ...

BackgroundImpaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve (ON), including Alzheimer's and Parkinson's disease, as well as frontotemporal dementia ...

Still displaying characteristics of their bacterial origin, such as autonomous division, motility, and their own genome, mitochondria remain an elusive component of modern eukaryotes. They produce most of the cell's energy in the form of adenosine triphosp ...

Bacteria often colonize their environment in the form of surface attached multicellular communities called biofilms. Biofilms grow from surface-attached cells that undergo division while self-embedding in a viscoelastic matrix. Biofilms grow at the surface ...

STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...

Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress

Chattez avec Graph Search

HPV16-Expressing Tumors Release Multiple IL-1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine

Neural anticipation of virtual infection triggers an immune response

Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays

Visualization and modelling of dynamic flow in fibrous preforms for liquid composite molding

Numerical simulation of immiscible incompressible viscous, viscoelastic and elastic multiphase flows

Three-dimensional buoyant hydraulic fractures: finite volume release

Highly Efficient Miniaturized Magnetorheological Valves Using Electropermanent Magnets

Ultra-High Sensitivity Silicon Nanowire Array Biosensor Based on a Constant-Current Method for Continuous Real-Time pH and Protein Monitoring in Interstitial Fluid

Noise-induced transitions past the onset of a steady symmetry-breaking bifurcation: The case of the sudden expansion

Mechanisms of axoneme and centriole elimination in Naegleria gruberi

Monitoring of Protein and pH Levels in Human Biofluids using FD-SOI Silicon Nanowire Arrays

Effect of wettability and textile architecture on fluid displacement and pore formation during infiltration of carbon fibrous preforms

Anomalous dissipation and other non-smooth phenomena in fluids

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

System for automated and dynamic cell culture

Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

Unraveling mitochondrial dynamics: exploring asymmetries and function through advanced microscopy

Biofilm morphogenesis on soft hydrogels

Membrane specificity of the human cholesterol transfer protein STARD4