3D Structure From 2D Microscopy Images Using Deep Learning

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Proteins are foundational biomolecules of life playing a crucial role in a myriad of biological processes. Their function often requires interplay with other biomolecules, including proteins themselves. Protein-protein interactions (PPIs) are essential for ...

Semi-supervised semantic segmentation methods leverage unlabeled data by pseudo-labeling them. Thus the success of these methods hinges on the reliability of the pseudo-labels. Existing methods mostly choose high-confidence pixels in an effort to avoid err ...

What changes with age? Results in reinforcement learning (RL) are mixed. Some studies found deteriorated RL performance in older participants compared to younger controls whereas other studies did not. Daniel et al. (J Neurosci 40(5):1084–1096, 2020. 10.15 ...

This paper presents a comparison of machine learning (ML) methods used for three-dimensional localization of partial discharges (PD) in a power transformer tank. The study examines ML and deep learning (DL) methods, ranging from support vector machines (SV ...

Decentralized learning (DL) is an emerging approach that enables nodes to collaboratively train a machine learning model without sharing raw data. In many application domains, such as healthcare, this approach faces challenges due to the high level of hete ...

In the rapidly evolving landscape of machine learning research, neural networks stand out with their ever-expanding number of parameters and reliance on increasingly large datasets. The financial cost and computational resources required for the training p ...

Visual affordance segmentation identifies image regions of an object an agent can interact with. Existing methods re-use and adapt learning-based architectures for semantic segmentation to the affordance segmentation task and evaluate on small-size dataset ...

Federated learning (FL) is a machine learning approach where nodes collaboratively train a global model. As more nodes participate in a round of FL, the effectiveness of individual model updates by nodes also diminishes. In this study, we increase the effe ...

Fluorescence lifetime imaging (FLI) has been receiving increased attention in recent years as a powerful diagnostic technique in biological and medical research. However, existing FLI systems often suffer from a tradeoff between processing speed, accuracy, ...

Driven by the need for more efficient and seamless integration of physical models and data, physics -informed neural networks (PINNs) have seen a surge of interest in recent years. However, ensuring the reliability of their convergence and accuracy remains ...

The visualization and manipulation of proteins in live cells are critical for studying complex biological processes. Self-labeling proteins do so by enabling the specific and covalent attachment of synthetic probes, offering unprecedented flexibility in th ...

When a plasma disrupts in a tokamak, significant heat and electromagnetic loads are deposited onto the surrounding device components. These forces scale with plasma current and magnetic field strength, making disruptions one of the key challenges for futur ...

Epilepsy, a major neurological disease, requires careful diagnosis and treatment. However, the detection of epileptic seizures remains a significant challenge. Current clinical practice relies on expert analysis of EEG signals, a process that is time-consu ...

Cyclic peptides are attractive for drug discovery due to their excellent binding properties and the potential to cross cell membranes. However, by far not all cyclic peptides are cell permeable, and measuring or predicting their membrane permeability is no ...

In this thesis we explore the applications of projective geometry, a mathematical theory of the relation between 3D scenes and their 2D images, in modern learning-based computer vision systems. This is an interesting research question which contradicts the ...

The invention of 3D atomic force microscopy (3D-AFM) has enabled visualizing subnanoscale 3D hydration structures. Meanwhile, its applications to imaging flexible molecular chains have started to be experimentally explored. However, the validity and princi ...

Whole-cell biophotovoltaic (BPV) devices leverage photoautotrophic microorganisms like cyanobacteria to convert sunlight and water into bioelectricity. They are capable of growing on sequestered carbon dioxide (CO2), eliminating the need to add exogenous o ...

Training data mixtures greatly impact the generalization performance of large language models. Existing domain reweighting methods often rely on costly weight computations and require retraining when new data is introduced. To this end, we introduce a flex ...

Modern neuroscience research is generating increasingly large datasets, from recording thousands of neurons over long timescales to behavioral recordings of animals spanning weeks, months, or even years. Despite a great variety in recording setups and expe ...

3D Structure From 2D Microscopy Images Using Deep Learning

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Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

Weighting Pseudo-labels via High-Activation Feature Index Similarity and Object Detection for Semi-supervised Segmentation

Intact reinforcement learning in healthy ageing

Partial discharge localization in power transformer tanks using machine learning methods

Fair Decentralized Learning

Random matrix methods for high-dimensional machine learning models

Segmenting Object Affordances: Reproducibility and Sensitivity to Scale

Harnessing Increased Client Participation with Cohort-Parallel Federated Learning

Coupling a recurrent neural network to SPAD TCSPC systems for real-time fluorescence lifetime imaging

Residual-based attention in physics-informed neural networks

Exploiting Covalent Chemical Labeling with Self-Labeling Proteins

Plasma state monitoring and disruption characterization using multimodal VAEs

Resource-Efficient Continual Learning for Personalized Online Seizure Detection

Bulk measurement of membrane permeability for random cyclic peptides in living cells to guide drug development

Incorporating Projective Geometry into Deep Learning

Revealing the Mechanism Underlying 3D-AFM Imaging of Suspended Structures by Experiments and Simulations

Bioanode engineering for living solar cells

CHAMELEON: A Flexible Data-mixing Framework for Language Model Pretraining and Finetuning

Robust machine learning for neuroscientific inference