Mechanism of Shiga Toxin Clustering on Membranes

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Homogenization theory captures macroscopic flow discontinuities across Janus membranes

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Janus membranes, thin permeable structures with chemical and geometrical asymmetric properties, show great potential in industrial separation processes. Yet the link between the micro- and macro-scale behaviours of these membranes needs to be established r ...

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Micro- or nanostructured optical element

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A micro- or nanostructured optical element (1) is proposed comprising: a membrane (3) with an array of holes (5), the membrane (3) comprising a membrane light wave facing surface; an array of pillars (7) sized and shaped such that a respective pillar (7) i ...

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Structure of a membrane-bound menaquinol:organohalide oxidoreductase

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Organohalide-respiring bacteria are key organisms for the bioremediation of soils and aquifers contaminated with halogenated organic compounds. The major players in this process are respiratory reductive dehalogenases, corrinoid enzymes that use organohali ...

Nature Research2023

Structural diversity of photoswitchable sphingolipids for optodynamic control of lipid microdomains

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Sphingolipids are a structurally diverse class of lipids predominantly found in the plasma membrane of eukaryotic cells. These lipids can laterally segregate with other rigid lipids and cholesterol into liquid-ordered domains that act as organizing centers ...

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Simultaneous Electrophysiology and Imaging Reveal Changes in Lipid Membrane Thickness and Tension upon Uptake of Amphiphilic Gold Nanoparticles

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Amphiphilic gold core nanoparticles (AmNPs) striped with hydrophilic 11-mercapto-1-undecanesulfonate (MUS) and hydrophobic 1-octanethiol (OT) ligands are promising candidates for drug carriers that passively and nondisruptively enter cells. Yet, how they i ...

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Simultaneous membrane and RNA binding by Tick-Borne Encephalitis Virus capsid protein

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Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the end ...

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Unsupervised Graph Representation Learning with Cluster-aware Self-training and Refining

Yichen Xu, Qiang Liu

Unsupervised graph representation learning aims to learn low-dimensional node embeddings without supervision while preserving graph topological structures and node attributive features. Previous Graph Neural Networks (GNN) require a large number of labeled ...

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MPD and TMC supply as parameters to describe synthesis-morphology-performance relationships of polyamide thin film composite membranes

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This study assesses the influence during interfacial polymerization on polyamide thin film composite (TFC) morphology and performance of varying monomer concentrations and organic phases with widely varying physico-chemical characteristics (interfacial ten ...

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Towards ultrathin metal-organic frameworks membranes for high-performance separation

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Research on metal-organic frameworks (MOFs) based membranes has gained a lot of attention in the last decade thanks to the unique and highly versatile chemistry of MOFs, which allows one to synthesize a variety of structural dimensions, topologies, pore si ...

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Mechanical Immunoengineering of T Cells for Enhanced Cancer Immunotherapy

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Cancer is one of the leading causes of death globally. Immunotherapy represents one of the most promising cancer treatments inducing complete and durable responses in a fraction of cancer patients. Despite the unprecedented clinical success achieved by T c ...

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