Phosphocreatine line with changes in localised 31P MRS of exercising muscle at 7T

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Publications associées (29)

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Johan Auwerx, Richardus Houtkooper

Background: Nicotinamide riboside (NR) is an NAD(+) precursor that boosts cellular NAD(+) concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. ...

OXFORD UNIV PRESS2020

Metabolic rescue of muscle and muscle stem cells in muscle disease

Peiling Luan

Duchenne muscular dystrophy (DMD), caused by the mutation of dystrophin gene, is an X-linked disorder that affects 1 in 3500 males, leading to progressive muscle degeneration and eventually resulting in premature death. Increasing evidence indicates that D ...

EPFL2020

The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport

The small molecule kinase inhibitor SBI-0206965 was originally described as a specific inhibitor of ULK1/2. More recently, it was reported to effectively inhibit AMPK and several studies now report its use as an AMPK inhibitor. Currently, we investigated t ...

2020

Detection of movement onset using EMG signals for upper-limb exoskeletons in reaching tasks

Silvestro Micera

BackgroundTo assist people with disabilities, exoskeletons must be provided with human-robot interfaces and smart algorithms capable to identify the user's movement intentions. Surface electromyographic (sEMG) signals could be suitable for this purpose, bu ...

BioMed Central2019

Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities

Patrick Descombes, Sylviane Métairon, Sofia Moco, Sonia Karaz, Tanja Sonntag, Lei Feng

The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. H ...

Springer2019

HealthSit: Designing Posture-Based Interaction to Promote Exercise during Fitness Breaks

Pearl Pu Faltings, Yu Chen, Yuan Lu

This research was motivated by a desire to help office workers change their sedentary behavior because a prolonged sedentary posture increases the risks of developing musculoskeletal injuries and chronic diseases, thus threatening their physical and psycho ...

TAYLOR & FRANCIS INC2019

Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle

Tanja Sonntag

The progressive decline of muscle mass and function called sarcopenia is a multi-factorial process associated to frailty, disability, and low quality of life in the elderly. The co-factor nicotinamide adenine dinucleotide (NAD+) becomes a limiting factor i ...

EPFL2019

Towards an Adaptive Upper Limb Rehabilitation Game with Tangible Robots

Pierre Dillenbourg, Ayberk Özgür, Arzu Güneysu Özgür, Louis Pierre Faucon, Pablo Maceira Elvira, Wafa Monia Benkaouar Johal, Friedhelm Christoph Hummel, Maximilian Jonas Wessel, Andéol Geoffroy Cadic-Melchior

A key feature of a successful game is its ability to provide the player with an adequate level of challenge. However, the objective of difficulty adaptation in serious games is not only to maintain the player’s motivation by challenging, but also to ensure ...

2019

Ultra high magnetic field for glial contribution into brain metabolism studied by MR spectroscopy and CEST methods for molecular imaging of glycogen

Elise Marie Catherine Vinckenbosch

Magnetic resonance at ultra-high field increases signal and spectral dispersion. In this thesis, I use those characteristics to investigate three different subjects in 13C spectroscopy, hyperpolarized methods and chemical exchange saturation transfer (CEST ...

EPFL2018

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