Publications associées à Oxidative stability and microstructure of 5% fish-oil-enriched granola bars added natural antioxidants derived from brown alga Fucus vesiculosus

Compact and effective photon-resolved image scanning microscope

Fluorescence confocal laser-scanning microscopy (LSM) is one of the most popular tools for life science research. This popularity is expected to grow thanks to single-photon array detectors tailored for LSM. These detectors offer unique single-photon spati ...

Spie-Soc Photo-Optical Instrumentation Engineers2024

Electrospun zein incorporating phycocyanin and Spirulina extract: Fabrication, characterization, and potential application

Niloufar Sharif

Electrospinning was used to develop zein fibers containing phycocyanin and aqueous-ethanolic extract of Spirulina (AEES) for elucidating the potent packaging properties of phycocyanin and AEES on walnut samples. Morphological results revealed that using th ...

Elsevier2023

Impact of chlorination and ozonation of dissolved organic matter on its photo-induced production of long-lived photooxidants and excited triplet states

Silvio Canonica, Urs von Gunten, Stephanie Christa Remke, Joanna Maria Houska

Recent studies suggested that long-lived photooxidants (LLPO), which are reactive intermediates formed during irradiation of dissolved organic matter (DOM), may consist of phenoxyl radicals derived from phenolic moieties of the DOM. Besides the well-studie ...

PERGAMON-ELSEVIER SCIENCE LTD2023

Practical computational imaging by use of spatiotemporal light modulation: from simulations to applications in biological microscopy

François Thierry M Marelli

Optical microscopy is an essential tool for biologists, who are often faced with the need to overcome the spatial and temporal resolution limitations of their devices to capture finer details. As upgrading imaging hardware is expensive, computational metho ...

EPFL2023

Time-Resolved Scanning Ion Conductance Microscopy and Single-Molecule Spectroscopy

Samuel Mendes Leitão

The evolution of the 3D morphology is at the center of many relevant biological processes ranging from cellular differentiation to cancer invasion and metastasis. Microscopy techniques, such as electron microscopy (EM), super-resolution (SR) optical micros ...

EPFL2023

Photochemical oxidation of phenols and anilines mediated by phenoxyl radicals in aqueous solution

Silvio Canonica, Urs von Gunten, Stephanie Christa Remke

Reactive intermediates formed upon irradiation of chromophoric dissolved organic matter (CDOM) contribute to the degradation of various organic contaminants in surface waters. Besides well-studied "short-lived" photo oxidants, such as triplet state CDOM (3 ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Article Structure and functionality of a multimeric human COQ7:COQ9 complex

Matteo Dal Peraro, Luciano Andres Abriata

Coenzyme Q (CoQ) is a redox-active lipid essential for core metabolic pathways and antioxidant defense. CoQ is synthesized upon the mitochondrial inner membrane by an ill-defined "complex Q" metabolon. Here, we present structure-function analyses of a lipi ...

CELL PRESS2022

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Johan Auwerx, Pénélope Andreux, Pamela Solange Valdés Undurraga, Davide D'Amico, Anurag Singh

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its ...

2021

Phototransformation of Organic Contaminants in Aquatic Systems: Characterization of Long-Lived Photooxidants Derived from Dissolved Organic Matter

Stephanie Christa Remke

The increasing interest in the fate of organic contaminants in the aquatic environment requires the elucidation of relevant abiotic transformation processes. These processes often involve the ubiquitous dissolved organic matter (DOM), a complex mixture of ...

EPFL2021

Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules

Gerardo Turcatti, Michel Prudent, Benjamin Rappaz, Manon Sandra Bardyn, David Crettaz

An increase of oxygen saturation within blood bags and metabolic dysregulation occur during storage of red blood cells (RBCs). It leads to the gradual exhaustion of RBC antioxidant protective system and, consequently, to a deleterious state of oxidative st ...

2021

Weakly Supervised Deep Learning Methods for Biomicroscopy

Adrian Shajkofci

Optical microscopy, an invaluable tool in biology and medicine to observe and quantify cellular function, organ development, or disease mechanisms, requires constant trade-offs between spatial, temporal, and spectral resolution, invasiveness, acquisition t ...

EPFL2021

Systematic Tuning of Rhodamine Spirocyclization for Super-resolution Microscopy

Kai Johnsson, Lu Wang

Rhodamines are the most important class of fluorophores for applications in live-cell fluorescence microscopy. This is mainly because rhodamines exist in a dynamic equilibrium between a fluorescent zwitterion and a nonfluorescent but cell-permeable spirocy ...

AMER CHEMICAL SOC2021

Catechin reduces phototoxic effects induced by protoporphyrin IX-based photodynamic therapy in the chick embryo chorioallantoic membrane

Georges Wagnières, Jaroslava Joniová

Significance: Side effects of many cancer treatments are associated with the production of reactive oxygen species (ROS) in normal tissues. This explains why patients treated by photodynamic therapy (PDT) often suffer from skin photosensitization, whereas ...

SPIE Society of Photo-optical Instrumentation Engineers2020

Improving visible light photocatalytic inactivation of E. coli by inducing highly efficient radical pathways through peroxymonosulfate activation using 3-D, surface-enhanced, reduced graphene oxide (rGO) aerogels

César Pulgarin, Stefanos Giannakis, Minoo Karbasi

In this work, we synthesized highly porous reduced graphene oxide foams, presenting augmented antibacterial activity in presence/absence of peroxymonosulfate (PMS). To date, this is the first investigation of photocatalytic PMS disinfection by 3D-rGO mater ...

ELSEVIER SCIENCE SA2020

Therapeutic potential of glutathione-enhancers in stress-related psychopathologies

Pascal Steiner, Maria del Carmen Sandi Perez, Sarah Catherine Sonnay, Fiona Hollis, Laia Morato Fornaguera, Ioannis Zalachoras, Eva Ramos Fernandez

The mammalian brain has high energy demands, which may become higher in response to environmental challenges such as psychogenic stress exposure. Therefore, efficient neutralization of reactive oxygen species that are produced as a by-product of ATP synthe ...

2020

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

Johan Auwerx

Rationale: Hypertension represents a major risk factor for stroke, myocardial infarction, and heart failure and affects 30% of the adult population. Mitochondrial dysfunction contributes to hypertension, but specific mechanisms are unclear. The mitochondri ...

2020

Spatially-Variant CNN-Based Point Spread Function Estimation for Blind Deconvolution and Depth Estimation in Optical Microscopy

Michael Stefan Daniel Liebling, Adrian Shajkofci

Optical microscopy is an essential tool in biology and medicine. Imaging thin, yet non-flat objects in a single shot (without relying on more sophisticated sectioning setups) remains challenging as the shallow depth of field that comes with high-resolution ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

Enhanced transformation of sulfonamide antibiotics by manganese(IV) oxide in the presence of model humic constituents

Urs von Gunten, Jun Ma, Yang Song, Jin Jiang, Yang Zhou

In this study, a manganese(IV) oxide-mediator (MnO2-mediator) system for the abatement of sulfonamide antibiotics was evaluated. Two simple model humic constituents, syringaldehyde (SA) and acetosyringone (AS), could promote the transformation of sulfonami ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Imaging cellular ultrastructures using expansion microscopy (U-ExM)

Michaël Unser, Virginie Hamel, Paul Guichard, Denis Fortun, Davide Gambarotto

Determining the structure and composition of macromolecular assemblies is a major challenge in biology. Here we describe ultrastructure expansion microscopy (U-ExM), an extension of expansion microscopy that allows the visualization of preserved ultrastruc ...

2019

Two analytical approaches quantifying the electron donating capacities of dissolved organic matter to monitor its oxidation during chlorination and ozonation

Urs von Gunten

Electron-donating activated aromatic moieties, including phenols, in dissolved organic matter (DOM) partially control its reactivity with the chemical oxidants ozone and chlorine. This comparative study introduces two sensitive analytical systems to direct ...

2018