Development of mass spectrometric methods to understand the mechanism of action of transition metal-based anticancer compounds

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Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calcu ...

The synthesis of heterotrimetallic molecular cages is reported. The assemblies contain three types of coordination compounds: FeII clathrochelate complexes, AuI3(pyrazolate)3 complexes, and [PdII(pyridine)4]2+ complexes. The cages were obtained in a stepwi ...

The structural elucidation of metabolite molecules is important in many branches of the life sciences. However, the isomeric and isobaric complexity of metabolites makes their identification extremely challenging, and analytical standards are often require ...

This thesis investigates the magnetic properties of single atoms and molecules adsorbed on thin magnesium oxide decoupling layers, grown on a silver single crystal. To address these systems experimentally, we use a low temperature scanning tunneling micros ...

High-resolution ion mobility spectrometry (IMS) coupled with cryogenic infrared spectroscopy has proven to be a powerful technique for the identification of oligosaccharides. However, the need for an extensive database, combined with the scarcity of pure s ...

Permanent rainbow trout (Oncorhynchus mykiss) cell lines represent potential in vitro alternatives to experiments with fish. We here developed a method to assess the bioaccumulation potential of anionic organic compounds in fish, using the rainbow trout li ...

Cupredoxins are widely occurring copper-binding proteins with a typical Greek-key beta barrel fold. They are generally described as electron carriers that rely on a T1 copper centre coordinated by four ligands provided by the folded polypeptide. The discov ...

The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at different stages ...

Retinoblastoma, while relatively rare, stands as the most prevalent intraocular cancer. In Switzerland, the survival rate approaches 100%, but it drops to less than 50% in low-income countries. The current treatment options for retinoblastoma rely on a lim ...

STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...

Author summaryIn recent years, the application of deep learning represented a breakthrough in the mass spectrometry (MS) field by improving the assignment of the correct sequence of amino acids from observable MS spectra without prior knowledge, also known ...

Continuous development of thin film deposition technologies is essential for the fabrication of films that meet the specific requirements of their target applications and working conditions. Therefore, it is necessary to increase the number of accessible a ...

Development of mass spectrometric methods to understand the mechanism of action of transition metal-based anticancer compounds

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De novo designed proteins: a study in engineering novel folds and functions

Opportunities and challenges in design and optimization of protein function

Stepwise synthesis of heterotrimetallic FeII/PdII/AuI coordination cages

New Approach for the Identification of Isobaric and Isomeric Metabolites

Magnetism of Single Surface Adsorbed Atoms Studied with Radio-Frequency STM

Identification of human milk oligosaccharide positional isomers by combining IMS-CID-IMS and cryogenic IR spectroscopy

Investigating the bioaccumulation potential of anionic organic compounds using a permanent rainbow trout liver cell line

Beyond the coupled distortion model: structural analysis of the single domain cupredoxin AcoP, a green mononuclear copper centre with original features

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

Optimised three-dimensional in vitro retinoblastoma models tailored for drug discovery and clinical translatability

Membrane specificity of the human cholesterol transfer protein STARD4

Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics

Plasma-Assisted Hybrid Vapour Deposition Technology for Thin Film Fabrication