Publications associées à Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging

Publications associées (20)

Computational design of complex protein folds and soluble analogs of membrane proteins

Proteins are the molecular machines of life, driving essential biological processes such as enzymatic catalysis, cellular signaling, and immune responses. The ability to design entirely new proteins with desired structures and functions has immense implica ...

EPFL2025

A novel allosteric GCase modulator prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models

Maurizio Molinari

A slow decline in the autophagy-lysosomal pathway is a hallmark of the normal aging brain. Yet, an acceleration of this cellular function may propel neurodegenerative events. In fact, mutations in genes associated with the autophagy-lysosomal pathway can l ...

Springer Science and Business Media LLC2025

Exploiting Representation Similarities in Self-Supervised Learning for Vision Tasks

Thomas Grégoire Stegmüller

Recent progress in computer vision has been driven by a simple yet transformative observation: the potential of 30-year-old neural networks can be unlocked by massively scaling their parameters and the amount of human-labeled training data. This breakthrou ...

EPFL2025

Overcoming Distribution Shifts and Imbalance Challenges in Representation Learning for Deep Regression Models

Ismail Nejjar

Deep learning has shown remarkable potential for industrial applications, particularly in predictive maintenance and condition monitoring. A key challenge in this domain is prognostics, specifically predicting the Remaining Useful Life (RUL) of assets - a ...

EPFL2025

Person Re-Identification and its Application to Multi-Object Tracking

Vladimir Dominic K. Somers

Multi-Object Tracking (MOT) is a fundamental computer vision task that involves detecting objects of interest in video frames and associating detections of the same object across time to form trajectories. For association, appearance cues, extracted throug ...

EPFL2025

Learning to Reason with Neural Networks: Principles and Methods

Aryo Lotfi Jandaghi

This thesis focuses on understanding and improving the reasoning capabilities of neural networks. It develops theoretical results and empirical analyses to uncover reasoning potential and limitations, leveraging these insights to guide the design of improv ...

EPFL2025

Sequential Reasoning with Socially Caused Beliefs

Mert Kayaalp

Machine learning and artificial intelligence methods have achieved remarkable success, matching and even surpassing human capabilities in various complex tasks. However, many demonstrations have generally neglected a critical part of the intelligence that ...

EPFL2025

Explainable modeling for wind power forecasting: A Glass-Box model with high accuracy

Fernando Porté Agel, Jiannong Fang, Wenlong Liao

Machine learning models (e.g., neural networks) achieve high accuracy in wind power forecasting, but they are usually regarded as black boxes that lack interpretability. To address this issue, the paper proposes a glass-box model that combines high accurac ...

2025

Modelleyen: Continual Learning and Planning via Structured Modelling of Environment Dynamics

Boi Faltings, Zeki Doruk Erden

The current machine learning paradigm relies on continuous representations and fixed neural network architectures to approximate environmental structures, leading to challenges with continual learning, internal structure design, and goal-directed behavior ...

Springer Science and Business Media Deutschland GmbH2025

Scalable Multi-agent Reinforcement Learning for Residential Load Scheduling Under Data Governance

Zhaoming Qin

As a data-driven approach, multi-agent reinforcement learning (MARL) has made remarkable advances in solving cooperative residential load scheduling problems. However, centralized training, the most common paradigm for MARL, limits large-scale deployment i ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2025

Boosting Resource-Constrained Federated Learning Systems with Guessed Updates

Mohamed Yassine Boukhari, Anne-Marie Kermarrec, Rafael Pereira Pires, Rishi Sharma, Akash Balasaheb Dhasade

Federated learning (FL) enables a set of client devices to collaboratively train a model without sharing raw data. This process, though, operates under the constrained computation and communication resources of edge devices. These constraints combined with ...

Institute of Electrical and Electronics Engineers (IEEE)2025

Dark Noise Diffusion: Noise Synthesis for Low-Light Image Denoising

Liying Lu, Raphaël Wan-Li Marc Achddou, Sabine Süsstrunk

Low-light photography produces images with low signal-to-noise ratios due to limited photons. In such conditions, common approximations like the Gaussian noise model fall short, and many denoising techniques fail to remove noise effectively. Although deep- ...

2025

A comparative analysis of gene expression profiling by statistical and machine learning approaches

Anaïs Betsabeh Haget, Maria Boulougouri

Motivation Many machine learning (ML) models developed to classify phenotype from gene expression data provide interpretations for their decisions, with the aim of understanding biological processes. For many models, including neural networks, interpretati ...

OXFORD UNIV PRESS2025

LIONHEART: A Layer-based Mapping Framework for Heterogeneous Systems with Analog In-Memory Computing Tiles

David Atienza Alonso, Giovanni Ansaloni, Marina Zapater Sancho, Irem Boybat Kara, Flavio Ponzina, Joshua Alexander Harrison Klein, Yuxuan Wang, Abu Sebastian

When arranged in a crossbar configuration, resistive memory devices can be used to execute Matrix-Vector Multiplications (MVMs), the most dominant operation of many Machine Learning (ML) algorithms, in constant time complexity. Nonetheless, when performing ...

Institute of Electrical and Electronics Engineers (IEEE)2025

Segmenting Object Affordances: Reproducibility and Sensitivity to Scale

Andrea Cavallaro

Visual affordance segmentation identifies image regions of an object an agent can interact with. Existing methods re-use and adapt learning-based architectures for semantic segmentation to the affordance segmentation task and evaluate on small-size dataset ...

Springer Science and Business Media Deutschland GmbH2025

K-space physics-informed neural network (k-PINN) for compressed spectral mapping and efficient inversion of vibrations in thin composite laminates

Olga Fink

The vibrational response of structural components carries valuable information about their underlying mechanical properties, health status and operational conditions. This underscores the need for the development of efficient physics-based inversion algori ...

Elsevier BV2025

The effect of hydration and dynamics on the mass density of single proteins

Lucas Sebastian Powell-Rudden

The density of a protein molecule is a key property within a variety of experimental techniques. We present a computational method for determining protein mass density that explicitly incorporates hydration effects. Our approach uses molecular dynamics sim ...

2025

Bulk measurement of membrane permeability for random cyclic peptides in living cells to guide drug development

Nathan Moïse De Sadeleer, Christian Heinis, Alexander Lund Nielsen, Anne Sofie Luise Zarda, Rebecca Manuela Neeser

Cyclic peptides are attractive for drug discovery due to their excellent binding properties and the potential to cross cell membranes. However, by far not all cyclic peptides are cell permeable, and measuring or predicting their membrane permeability is no ...

Wiley2025

SaliencyMix plus : Noise-Minimized Image Mixing Method With Saliency Map in Data Augmentation

Zhixiong Jin

Data augmentation is vital in deep learning for enhancing model robustness by artificially expanding training datasets. However, advanced methods like CutMix blend images and assign labels based on pixel ratios, often introducing label noise by neglecting ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2025

Harnessing Increased Client Participation with Cohort-Parallel Federated Learning

Anne-Marie Kermarrec, Rafael Pereira Pires, Marinus Abraham de Vos, Akash Balasaheb Dhasade, Tuan Anh Nguyen

Federated learning (FL) is a machine learning approach where nodes collaboratively train a global model. As more nodes participate in a round of FL, the effectiveness of individual model updates by nodes also diminishes. In this study, we increase the effe ...

ACM2025