Towards non-parametric reconstruction of axon diameter distributions using diffusion MRI and regularized discrete linear modeling

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Axons are ultrathin membrane cables that are specialized for the conduction of action potentials. Although their diameter is variable along their length, how their morphology is determined is unclear. Here, we demonstrate that unmyelinated axons of the mou ...

Sharing data across institutions for genome-wide association studies (GWAS) would enhance the discovery of genetic variation linked to health and disease1,2. However, existing data-sharing regulations limit the scope of such collaborations3. Although crypt ...

Purpose: Although clinical 7T MRI offers various advantages compared to lower field strengths, achieving spatially uniform flip angle distributions remains a challenge. Sampling Perfection with Application optimized Contrast using different flip angle Evol ...

Neurodegenerative and neuroinflammatory disorders often involve complex pathophysiological mechanisms that are â to this date â only partially understood. A more comprehensive understanding of those microstructural processes and their characterization ...

Recently, the R2D2 paradigm, standing for ‘Residual-to-Residual DNN series for high-Dynamic-range imaging’, was introduced for image formation in Radio Interferometry (RI) as a learned version of the traditional algorithm CLEAN. The first incarnations of R ...

BACKGROUND AND PURPOSE: MS lesions exhibit varying degrees of axonal and myelin damage. A comprehensive description of lesion phenotypes could contribute to an improved radiologic evaluation of smoldering inflammation and remyelination processes. This stud ...

Low-light photography produces images with low signal-to-noise ratios due to limited photons. In such conditions, common approximations like the Gaussian noise model fall short, and many denoising techniques fail to remove noise effectively. Although deep- ...

Purpose: This study aims to evaluate two distinct approaches for fiber radius estimation using diffusion-relaxation MRI data acquired in biomimetic microfiber phantoms that mimic hollow axons. The methods considered are the spherical mean power-law approac ...

Goal: Structural brain graphs are conventionally limited to defining nodes as gray matter regions from an atlas, with edges reflecting the density of axonal projections between pairs of nodes. Here we explicitly model the entire set of voxels within a brai ...

Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly mani ...

Situational awareness strategies are essential for the reliable and secure operation of the electric power grid which represents critical infrastructure in modern society. With the rise of converter-interfaced renewable generation and the consequent shift ...

The Poisson cluster rainfall generation model has been underutilized in urban hydrological simulations due to challenges in reproducing fine-scale extreme precipitation. This study addresses this issue by comprehensively validating four variants of Poisson ...

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Objectives Bictegravir is an integrase strand transfer inhibitor widely prescribed due to its good efficacy and safety profile. Its pharmacokinetic (PK) profile has not been described in real-world settings yet. This study aimed to characterize bictegravir ...

We enable the estimation of the per-axon axial diffusivity from single encoding, strongly diffusion-weighted, pulsed gradient spin echo data. Additionally, we improve the estimation of the per-axon radial diffusivity compared to estimates based on spherica ...

We review the work that has been conducted in the past years to understand when and why significant epidemics may arise even though a disease is not bound to become endemic in the long run i.e. subthreshold outbreaks. In particular, we describe the methods ...

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often differentially affected in human neurodegenerative diseases across CNS region, age and sex. We hypothesize that ...

Neurons primarily communicate through release of neurotransmitter from presynaptic specialisations along their axonal arborisations. In order to understand the functional role of a specific neuron, it is therefore of great interest to know the structure of ...

We discuss the effects of image scanning microscopy using doughnut beam illumination on the properties of signal strength and integrated intensity. Doughnut beam illumination can give better optical sectioning and background rejection than Airy disk illumi ...

Towards non-parametric reconstruction of axon diameter distributions using diffusion MRI and regularized discrete linear modeling

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Membrane mechanics dictate axonal pearls-on-a-string morphology and function

Secure and federated genome-wide association studies for biobank-scale datasets

Individually optimized dynamic parallel transmit pulses for 3D high‐resolution SPACE imaging at 7T

Development and clinical validation of computational imaging biomarkers for neurodegenerative diseases

S-R2D2: a spherical extension of the R2D2 deep neural network series paradigm for wide-field radio-interferometric imaging

Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes

Dark Noise Diffusion: Noise Synthesis for Low-Light Image Denoising

Pore size estimation in axon-mimicking microfibers with diffusion-relaxation MRI

Voxel-Wise Brain Graphs From Diffusion MRI: Intrinsic Eigenspace Dimensionality and Application to Functional MRI

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

Functional-Basis Analysis of Non-Stationary Signals in Modern Power Grids: Theory and Implementation in Embedded Systems

Context-Specific Selection of Poisson cluster rainfall models for accurate urban hydrological simulations

White adipose tissue distribution and amount are associated with increased white matter connectivity

Population pharmacokinetics of bictegravir in real-world people with HIV

Axial and radial axonal diffusivities and radii from single encoding strongly diffusion-weighted MRI

Epidemicity conditions in spatial models of infectious diseases

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function

Axonal projections from mouse whisker-related sensory cortex

Image scanning microscopy with a doughnut beam: signal strength and integrated intensity