Assessment of metal-based dihydrofolate reductase inhibitors on a novel mesofluidic platform

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The chemistry of lanthanides is limited to one electron transfer reactions due to the difficulty of accessing multiple oxidation states. Here we report that a redox-active ligand combining three siloxides with an arene ring in a tripodal ligand can stabili ...

ABCG2 is an ATP-binding cassette transporter that exports a wide range of xenobiotic compounds and has been recognized as a contributing factor for multidrug resistance in cancer cells. Substrate and inhibitor interactions with ABCG2 have been extensively ...

This work demonstrated that consolidated bioprocessing is a promising concept for conversion of lignocellulose to ethanol at industrial scale. CBP offers great cost saving potential, is feasible to be operated continuously and may be scaled up due to exten ...

Sirtuin 5 (SIRT5) is a protein lysine deacylase enzyme that regulates diverse biology by hydrolyzing epsilon-N-carboxyacyllysine posttranslational modifications in the cell. Inhibition of SIRT5 has been linked to potential treatment of several cancers but ...

We explain the construction of minimal tilting complexes for objects of highest weight categories and we study in detail the minimal tilting complexes for standard objects and simple objects. For certain categories of representations of complex simple Lie ...

Fast advances in soft robotics and tissue engineering demand for new soft materials whose mechanical properties can be interchangeably and locally varied, thereby enabling, for example, the design of soft joints within an integral material. Inspired by nat ...

Four bipyridine-type ligands variably derivatized with two bioactive groups (taken from ethacrynic acid, flurbiprofen, biotin, and benzylpenicillin) were prepared via sequential esterification steps from commercial 2,2'-bipyridine-4,4'-dicarboxylic acid an ...

Ribonucleotide reductase (RNR) is an essential enzyme in DNA biogenesis and a target of several chemotherapeutics. Here, we investigate how antileukemic drugs (e.g., clofarabine [CIF]) that target one of the two subunits of RNR, RNR-alpha, affect noncanoni ...

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death in co-culture. Enhancing NAD(+) availability, or increasing the expression of the NAD(+)-depende ...

Living organisms can catalyze many thousands of biochemical reactions that they use to convert energy and matter, which provides them with the essentials for life. The sum of these chemical reactions happening in an organism is called metabo-lism. Understa ...

Drug combinations are extensively used to treat cancer and are often selected according to complementary mechanisms. Here, we describe a cell-based high-throughput screening assay for identification of synergistic combinations between broadly applied plati ...

We consider a natural subclass of harmonic maps from a surface into G/T, namely cyclic primitive maps. Here G is any simple real Lie group (not necessarily compact), T is a Cartan subgroup and both are chosen so that there is a Coxeter automorphism on G(C) ...

Ruthenium(II) arene complexes of 1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane (CAP) were obtained. Cytotoxicity studies against cancer cell lines reveal higher activity than the corresponding PTA analogues and, in comparison to the effects on noncancer ...

Over the past decades, there has been a dramatic change in the types and amounts of metal ions in the biosphere, since we have introduced huge amount of metal waste into our environment in the course of industrialization of our society. Most of the metal c ...

Metal based anti-cancer drugs (metallodrugs) such as cisplatin are a cornerstone of cancer chemotherapy. However, development of this class of compound has been hindered by our lack of understanding of how they function. This is mainly because existing met ...

Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high percentage of ison ...

We present a model-based method, designated Inverse Metabolic Control Analysis (IMCA), which can be used in conjunction with classical Metabolic Control Analysis for the analysis and design of cellular metabolism. We demonstrate the capabilities of the met ...

A finitely generated subgroup F of a real Lie group G is said to be Diophantine if there is beta > 0 such that non-trivial elements in the word ball B-Gamma(n) centered at 1 is an element of F never approach the identity of G closer than broken vertical ba ...

Enzymes are biocatalysts widely used in a large number of industrial biotech processes as they offer clear advantages over their chemical counterparts. Indeed, enzymes often show high substrate selectivity along with elevated turnover rates. Enzymatic cata ...

Platinum-based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors. However, their effectiveness is limited by drug resistance, which, in some cancers, has been associated with an ...

Assessment of metal-based dihydrofolate reductase inhibitors on a novel mesofluidic platform

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Isolation and redox reactivity of cerium complexes in four redox states

Structural Basis of the Allosteric Inhibition of Human ABCG2 by Nanobodies

Model-based scale-up of a continuously operated consolidated bioprocess based on a microbial consortium for the production of ethanol

Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme

On minimal tilting complexes in highest weight categories

Load-bearing hydrogels ionically reinforced through competitive ligand exchanges

Hetero-Bis-Conjugation of Bioactive Molecules to Half-Sandwich Ruthenium(II) and Iridium(III) Complexes Provides Synergic Effects in Cancer Cell Cytotoxicity

Clofarabine Commandeers the RNR-alpha-ZRANB3 Nuclear Signaling Axis

Evaluation of the NAD(+) biosynthetic pathway in ALS patients and effect of modulating NAD(+) levels in hSOD1-linked ALS mouse models

Modeling, predicting and mining metabolism at atom-level resolution

Screening-based approach to discover effective platinum-based chemotherapies for cancers with poor prognosis

Toda frames, harmonic maps and extended Dynkin diagrams

New Class of Half-Sandwich Ruthenium(II) Arene Complexes Bearing the Water-Soluble CAP Ligand as an in Vitro Anticancer Agent

Investigation of Key Parameters Affecting Ion-Capturing Abilities of Mixed-Ligand Protected Gold Nanoparticles

Development of mass spectrometric methods to understand the mechanism of action of transition metal-based anticancer compounds

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism

Diophantine properties of nilpotent Lie groups

Reversible supramolecular modification of surfaces

Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation