Publications associées à Constitutionally selective amplification of multicomponent 84-membered macrocyclic hosts for (−)-cytidine•H+

Publications associées (12)

The role of medial amygdala inhibitory neurons in regulating social behavior

Aggression is an evolutionary conserved social behavior that is necessary for an animalÂŽs survival. The neural substrates coordinating aggression are known to exist in the amygdala and the hypothalamus. While the medial amygdala (MeA) and the ventrolatera ...

EPFL2021

Image-Based Marker-Free Screening of GABA(A) Agonists, Antagonists, and Modulators

Pierre Marquet, Gerardo Turcatti, Benjamin Rappaz, Pascal Jourdain, Fabien Kuttler, Damiano Banfi

The ionotropic GABA(A) receptors represent the main target for different groups of widely used drugs having hypnotic and anxiolytic effects. So far, most approaches used to assess GABA activity involve invasive low -throughput electrophysiological techniqu ...

2019

Molecular tunability of surface-functionalized metal nanocrystals for selective electrochemical CO2 reduction

Raffaella Buonsanti, Mounir Driss Mensi, James Richard Pankhurst, Yannick Thomas Guntern

Organic ligands are used in homogeneous catalysis to tune the metal center reactivity; in contrast, clean surfaces are usually preferred in heterogeneous catalysis. Herein, we demonstrate the potential of a molecular chemistry approach to develop efficient ...

2019

Single-molecule microscopy to study plasma membrane receptor dynamics

Luc Veya

Cell surface receptors allowthe cell to sense and respond to external signals. Receptor malfunctions are associated with many diseases. The diffusional behavior of receptors is of particular interest to understand how the cell modulates receptor function i ...

EPFL2016

Development of Stapling Methods by Selective Side Chain Modifications of Bioactive Peptides

Christopher Matthew Bandeli Kourra

Cyclic peptide therapeutics fill the gap between small molecules (5000 Da) as a separate class of drugs, combining the advantages of both in terms of high selectivity, bioavailability, synthetic accessibility and low toxicity. Howe ...

EPFL2016

Distributed digital real-time control system for TCV tokamak

Olivier Sauter, Basil Duval, Stefano Coda, Jean-Marc Moret, Federico Alberto Alfredo Felici, Damien Fasel, Philippe Marmillod, James Paley, Hoang Bao Le

A new digital feedback control system (named the SCD "Systeme de Controle Distribue") has been developed, integrated and used successfully to control TCV (Tokamak a Configuration Variable) plasmas. The system is designed to be modular, distributed, and sca ...

Elsevier Science Sa2014

Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway

Horst Arthur Vogel, Shuguang Yuan

Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, ...

Nature Publishing Group2014

Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex

Magnetic resonance spectroscopy (MRS) allows measurement of neurotransmitter concentrations within a region of interest in the brain. Inter-individual variation in MRS-measured GABA levels have been related to variation in task performance in a number of r ...

2011

Functional Nanostructures Based on Organometallic Half-Sandwich Complexes

Hexanuclear coordination cages of the formula [(C5Me4R)M(C7H3NO 4)]6 (M = Rh, Ir; R = Me, H) were obtained by stepwise reaction of [(C5Me4R)M(μ-Cl)Cl]2 with, first AgOAc and then pyridine-3,5-dicarboxylic acid. Crystallographic analyses show that the cages ...

EPFL2010

Ordering and Stabilization of Metal-Organic Coordination Chains by Hierarchical Assembly through Hydrogen Bonding at a Surface

Klaus Kern

Wiley-VCH Verlag GmbH2008

Growth and characterization of specific self-assembled supramolecular architectures at crystal surfaces

Marta Canas Ventura

In the framework of this thesis self-assembled supramolecular architectures of several molecular species on crystal metal surfaces are characterized. These investigations combine results obtained by means of scanning tunneling microscopy (STM), scanning tu ...

EPFL2008

Utilization of Self-Sorting Processes to Generate Dynamic Combinatorial Libraries with New Network Topologies

Rosario Scopelliti, Kay Severin

The synthesis of water-sol., organometallic macrocycles is described. They were obtained by self-assembly in reactions of the half-sandwich complexes [{Ru(C6H5Me)Cl2}2], [{Ru(p-cymene)Cl2}2], [{Rh(Cp)Cl2}2], and [{Ir(Cp*)Cl2}2] with the ligand 5-dimethylam ...

2006