Can Mutational Analysis Be Used To Assist Structure Determination of Peptides?

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Post-translational modifications (PTMs) play a pivotal role in regulating protein structure, interaction, and function. Aberrant PTM patterns are associated with diseases. Moreover, individual PTMs have a complex interaction with each other, known as PTM c ...

The phenomenon of allostery, a general property in proteins that has been heralded as "the second secret of life" remains elusive to our understanding and even more challenging to incorporate into protein design. One example of allosteric proteins with gre ...

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Selective synthesis of nanocluster (NC) isomers with tailored structures holds significant importance for enhancing their applications. Here, we develop an effective strategy for the selective synthesis of CdS NC isomers through the judicious choice of a p ...

Posttranslational modifications (PTMs) of proteins play central roles in regulating the protein structure, interactome, and functions. A notable modification site is the aromatic side chain of Tyr, which undergoes modifications such as phosphorylation and ...

Peroxisomes are eukaryotic organelles that are essential for multiple metabolic pathways, including fatty acid oxidation, degradation of amino acids, and biosynthesis of ether lipids. Consequently, peroxisome dysfunction leads to pediatric-onset neurodegen ...

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The geometry of biomolecules isolated in the gas phaseusuallydiffers substantially from their native structures in aqueous solution,which are the only ones truly relevant to life science. To connectthe high resolution of cold ion spectroscopy that can be a ...

Can Mutational Analysis Be Used To Assist Structure Determination of Peptides?

Chattez avec Graph Search

Hydrophobic Interaction and its Small Molecule effect

Methods for high-throughput synthesis and screening of peptide libraries

Investigating the intra-molecular and inter-molecular effects of post-translational modifications on intrinsically disordered protein regions and structured protein regions

From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Influence of Amino Acid Substitutions in Capsid Proteins of Coxsackievirus B5 on Free Chlorine and Thermal Inactivation

Towards improving full-length ribosome density prediction by bridging sequence and graph-based representations

Opportunities and challenges in design and optimization of protein function

Magnetism of Single Surface Adsorbed Atoms Studied with Radio-Frequency STM

How Reproducible is the Synthesis of Zr-Porphyrin Metal-Organic Frameworks? An Interlaboratory Study

Predicting protein interactions using geometric deep learning on protein surfaces

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

Interrupted Polonovski Strategy for the Synthesis of Functionalized Amino Acids and Peptides

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

Mixed ionic-electronic conduction in Ruddlesden-Popper and Dion-Jacobson layered hybrid perovskites with aromatic organic spacers

Carboxylic acid isomer-directed synthesis of CdS nanocluster isomers

A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Microbial hydrogen sinks in the sand-bentonite backfill material for the deep geological disposal of radioactive waste

Structural heterogeneity of the ion and lipid channel TMEM16F

Revealing the Structure of Tryptophan in Microhydrated Complexes by Cold Ion Spectroscopy