A Drug Release Mechanism Controlled by Hydrophobic/Hydrophilic Balance of the Matrix. Theoretical and Experimental Perspectives

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A birth-death-migration model for life in astrophysical environments

Claudio Grimaldi

To assess the number of life-bearing worlds in astrophysical environments, it is necessary to take the intertwined processes of abiogenesis (birth), extinction (death), and transfer of life (migration) into account. We construct a mathematical model that i ...

OXFORD UNIV PRESS2021

Poster World. Bespoke AI Meets Curator Expertise for Public Engagement

Mathieu Salzmann, Nicolas Henchoz, Delphine Ribes Lemay, Emily Clare Groves, Lara Jacqueline Défayes, Andrea Regula Schneider, André Viegas Andrade

Though museums are digitising their archives, online consultations remain low. New forms of engagement bring these digital memories to life and can support museums in maintaining and developing digital resources. Artificial Intelligence presents opportunit ...

2022

Construction of optimal spectral methods in phase retrieval

Lenka Zdeborová, Florent Gérard Krzakala

We consider the phase retrieval problem, in which the observer wishes to recover a n-dimensional real or complex signal X⋆ from the (possibly noisy) observation of |ΦX⋆|, in which Φ is a matrix of size m×n. We consider a \emph{high-dimensional} setting whe ...

2021

Combi-seq for multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

Christoph Merten, Ngoc Hien Du

Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is challenging and would benefit from high-content, ...

Nature Research2022

The Dimension of the Body in Higher Education: Matrix of Meanings in Students’ Diaries

Simon Nessim Henein, Ramiro Tau

In this paper, we attempt to show some consequences of bringing the body back into higher education, through the use of performing arts in the curricular context of scientific programs. We start by arguing that dominant traditions in higher education repro ...

2022

Laser-induced liquid micro-jets for drug delivery

Jan Krizek

Jet injection devices have been studied and developed for transdermal drug delivery to avoid the use of needles. Such contact-less devices provide several advantages such as better dose control, lateral and depth localisation, lower collateral damage than ...

EPFL2021

DNA origami nanostructures for controlled therapeutic drug delivery

Maartje Martina Cornelia Bastings, Jorieke Weiden

DNA nanostructures are emerging as a versatile platform for controlled drug delivery as a result of recent progress in production yield and strategies to obtain prolonged stability in biological environments. The construction of nanostructures from this un ...

2021

Reversible and Broad-Range Oxygen Sensing Based on Purely Organic Long-Lived Photoemitters

Esther Amstad, Efe Armagan

The detection of oxygen (O-2) by optical sensors is of growing importance, for example, in biology, life science, environmental science, and aerodynamics, where the composition of gases is crucial for many applications. Purely organic optical O-2 sensors a ...

2021

Fabrication of micrometer-sized drops as templates for particles

Mathias Steinacher

Drops are omnipresent in our daily life for example in the form of rain drops or as oil drops in a salad dressing. On a technological basis, drops can be used to conduct chemical or biological reactions. These drops often serve as templates to produce mate ...

EPFL2021

Towards the Development of Orally Available Peptide Therapeutics

Christian Heinis, Xudong Kong

Peptides have a number of attractive properties that make them an interesting modality for drug development, including their ability to bind challenging targets, their high target specificity, and their non-toxic metabolic products. However, a major limita ...

2021

Towards Interactions Through Differentiable-Non-Differentiable Scale Transitions In Scale Relativity Theory

Maria-Alexandra Paun

It is shown that, in the framework of Scale Relativity Theory, correlations of type informational entropy/cross entropy - probability density, in the description of the dynamics of any complex system, can be perceived as interactions. Explaining these inte ...

UNIV POLITEHNICA BUCHAREST, SCI BULL2021