Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

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KRAB Zinc Finger Proteins (KZFPs) are a large mammalian transcription factor family, which has mainly been studied for its ability to silence and tame transposable elements (TEs) - a controlling effect brought by the ubiquitous KZFP protein partner, TRIM28 ...

Optical biosensors offer significant advantages for minimally invasive in vivo and in vitro diagnostics. Optical sensors that are based on the fluorescence of semiconducting single-walled carbon nanotubes (SWCNTs) especially benefit from a near-infrared (n ...

The interplay of synthetic DNA nanostructures and lipid membranes is an exciting frontier in bioengineering, with the potential to transform synthetic biology and nanomedicine. However, the fundamental principles underlying their interactions-particularly ...

Understanding the impact of composition and interfaces between metals and oxides is a goal of interest for many chemical reactions. Herein, we propose a framework to map correlations between the electrochemical behavior of the oxide and the stability and r ...

Primary diamines are valuable yet challenging to synthesize due to issues such as product and intermediate condensation and catalyst poisoning. To address these problems, effective synthesis systems must be explored. Here, 2,5-bis(aminomethyl)furan (BAMF), ...

Protein stabilization has a crucial rule sustaining biological functionality, disease prevention, and pharmaceutical formulation stabilization, and yet its stabilization mechanism by small molecules such as amino acids is not fully understood. In this work ...

Protein–ligand interactions (PLIs) determine the efficacy and safety profiles of small molecule drugs. Existing methods rely on either structural information or resource-intensive computations to predict PLI, casting doubt on whether it is possible to perf ...

The cell cycle-regulated DNA methyltransferase CcrM is conserved in most Alphaproteobacteria, but its role in bacteria with complex or multicentric genomes remains unexplored. Here, we compare the methylome, the transcriptome and the phenotypes of wild-typ ...

The control of eukaryotic gene expression is intimately connected to highly dynamic chromatin structures. Gene regulation relies on activator and repressor transcription factors (TFs) that induce local chromatin opening and closing. However, it is unclear ...

Proteins are foundational biomolecules of life playing a crucial role in a myriad of biological processes. Their function often requires interplay with other biomolecules, including proteins themselves. Protein-protein interactions (PPIs) are essential for ...

Cell-cell communication is fundamental for immune balance. Multivalent interactions of surface receptors at immune interfaces drive specific communication, with stimulatory and inhibitory signals guiding the immune outcome. Notably, the valency, affinity, ...

Cation exchange offers a strong postsynthetic tool for nanoparticles that are unachievable via direct synthesis, but its velocity makes observing the onset of the reaction in the liquid state almost impossible. After successfully proving that cation exchan ...

Proteins control nearly every facet of life on a molecular level. Proteins are formed from linear strings of amino acids, which fold into three-dimensional structures that can enact functions. Evolution has created highly efficient proteins in diverse fold ...

The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...

The goal of my PhD was the development of a new method for unselective surface labeling, not substrate-specific, that would give access to direct visualization of any surface interactions. In order to achieve this challenging goal, we wanted to develop a g ...

Beyond their original capability to grab and hold tiny objects, optical tweezers have emerged as a powerful tool to investigate fundamental physics at microscopic scales. A precise characterization of the optical trap is one of the key requirements in such ...

The binding and catalytic functions of proteins are generally mediated by a small number of functional residues held in place by the overall protein structure. Here, we describe deep learning approaches for scaffolding such functional sites without needing ...

The climate fluctuations of the Quaternary shaped the movement of species in and out of glacial refugia. In Europe, the majority of species followed one of the described traditional postglacial recolonization routes from the southern peninsulas towards the ...

Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

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Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification

Designing DNA-based nanotubes as near-infrared sensors for detecting cancer biomarkers

Electrostatic and Hydrophobic Mediation in DNA/Lipid Interactions: Toward the Design of Tailored DNA/Membrane Interfaces

The Chemical Nature of the Oxide Directs the Stability and Reactivity of Copper|Oxide Interfaces in the Electrochemical CO2 Reduction Reaction

Targeted Conversion of Biomass into Primary Diamines via Carbon Shell-Confined Cobalt Nanoparticles

Hydrophobic Interaction and its Small Molecule effect

G–PLIP: Knowledge graph neural network for structure-free protein–ligand bioactivity prediction

DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen

Individual transcription factors modulate both the micromovement of chromatin and its long-range structure

Engineering novel protein interactions with therapeutic potential using deep learning-guided surface design

Exploring the interplay of molecular pattern and valency for selective interactions at the bio-interface

Thermally Promoted Cation Exchange at the Solid State in the Transmission Electron Microscope: How It Actually Works

De novo designed proteins: a study in engineering novel folds and functions

PSGL-1 is an evolutionarily conserved antiviral restriction factor

Azide-Containing Hypervalent Iodine Reagents for Biomolecules Functionalization

Surfactants Control Optical Trapping near a Glass Wall

Scaffolding protein functional sites using deep learning

Unexpected post‐glacial colonisation route explains the white colour of barn owls ( Tyto alba ) from the British Isles