Impact of substrate clogging on vertical connectivity

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The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Paul Joseph Dyson, Irina Sinenko, Roland Christopher Turnell-Ritson

Retinoblastoma is a rare childhood cancer of the eye. Of the small number of drugs are used to treat retinoblastoma, all have been repurposed from drugs developed for other conditions. In order to find drugs or drug combinations better suited to the improv ...

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2023

Homogeneous Environmental Selection Structures the Bacterial Communities of Benthic Biofilms in Proglacial Floodplain Streams

Tom Ian Battin, Hannes Markus Peter, Tyler Joe Kohler, Susheel Bhanu Busi, Grégoire Marie Octave Edouard Michoud, Stylianos Fodelianakis, Massimo Bourquin, Leïla Ezzat, Jade Brandani

Streams draining proglacial floodplains harbor benthic biofilms comprised of diverse microbial communities. These high-mountain ecosystems are rapidly changing with climate warming, and it is therefore critical to better understand the mechanisms underlyin ...

AMER SOC MICROBIOLOGY2023

Continuous monitoring of morphological changes from sediment augmentation by field measurements and flume experiments

Giovanni De Cesare, Christian Mörtl

In this study, we present results from continuous field monitoring and a flume ex-periment of a sediment augmentation measure in a residual flow reach of the Swiss midlands. A straight morphological channel with fixed bed material was constructed to repres ...

2023

Experimental modeling of fine sediment routing: SEDMIX device with thrusters

Giovanni De Cesare, Azin Amini, Montana Marshall

Reservoir sedimentation is a key challenge for storage sustainability because it causes volume loss, affecting hydropower production capacity, dam safety, and flood management. A preliminary EPFL study proposed and studied an innovative device (called SEDM ...

CRC Press/Balkema2023

Enhancing Flood Resilience: Sediment Management in Le Bez Torrent

Giovanni De Cesare, Azin Amini, Romain Nathan Hippolyte Merlin Van Mol

In the canton of Bern, Switzerland, the “Le Bez” torrent is known for its flash floods, causing sediment and wood debris buildup in Villeret village settled on the alluvial fan. To mitigate this issue, a sediment/wood trap system is being implemented upstr ...

Swiss Academy of Sciences (SCNAT)2023

Influence of channel geomorphic units on bedload transport and river morphology during low‐magnitude bed‐forming floods coupled with sediment augmentation

Giovanni De Cesare, Severin Stähly, Christian Mörtl, Robin Schroff

In this study, we map different types of channel geomorphic units in a sediment-starved, residual-flow reach before and after an artificial flood. Bedload particles of a previous sediment augmentation measure are tracked with passive integrated transponder ...

2023

Hydromorphological assessment of sediment augmentation measures in gravel-bed rivers

Christian Mörtl

In the riverine environment, the riverscape, sediment and flow regime are essential drivers for natural habitat dynamics. Today, most water courses in Europe are regulated, and their natural dynamics are impaired. Flood releases coupled with the artificial ...

EPFL2023

Why do we need so many proteins? A physical insight into the collaboration of Hsp70 and DnaJ

Adélaïde Alice Mohr

The Hsp70 cycle is a key element of protein homeostasis, which is essential to avoid protein aggregation and protein-related diseases. Despite many experimental observations of the interaction between Hsp70, its co-chaperone DnaJ and various substrates, li ...

EPFL2023

Chromium bioavailability in aquatic systems impacted by tannery wastewaters. Part 1: Understanding chromium accumulation by indigenous chironomids

Dominik Józef Kubicki

The tanning industry uses large quantities of Cr whose contribution to the contaminant burden of aquatic organismsis not yet fully understood. The present study investigated Cr bioaccumulation by indigenous chironomids in a freshwater ecosystem impacted by ...

2019