Publications associées à 3D near-infrared imaging based on a single-photon avalanche diode array sensor: A new perspective on reconstruction algorithms

Silicon CMOS and InGaAs(P)/InP SPADs for NIR/SWIR detection

Applications demanding imaging at low-light conditions at near-infrared (NIR) and short-wave infrared (SWIR) wavelengths, such as quantum information science, biophotonics, space imaging, and light detection and ranging (LiDAR), have accelerated the develo ...

EPFL2024

Subsurface fluorescence time-of-flight imaging using a large-format single-photon avalanche diode sensor for tumor depth assessment

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Yichen Feng

Significance: Fluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible to detect by the naked eye. Such phenomena include tissue perfusion or molecula ...

SPIE Society of Photo-optical Instrumentation Engineers2024

Advanced Silicon and SWIR Single-Photon Avalanche Diodes: Design, Simulation, and Characterization

Ekin Kizilkan

Low-level light detection with high spatial and timing accuracy is a growing area of interest by virtue of applications such as light detection and ranging (LiDAR), biomedical imaging, time-resolved Raman spectroscopy, and quantum applications. Single-phot ...

EPFL2024

A fatty-acid based probe for near-infrared fluorescence guided surgery of glioblastoma

Elena Goun, Pavlo Khodakivskyi

High-grade gliomas (HGG) are the most common and most aggressive primary tumors of the brain. Despite recent advances in neuro-oncology survival of these tumors remains around 12-15 months. The first-line of treatment is surgical resection. However, due to ...

Spie-Int Soc Optical Engineering2024

Automated all-functionals infrared and Raman spectra

Nicola Marzari, Lorenzo Bastonero

Infrared and Raman spectroscopies are ubiquitous techniques employed in many experimental laboratories, thanks to their fast and non-destructive nature able to capture materials' features as spectroscopic fingerprints. Nevertheless, these measurements freq ...

Nature Portfolio2024

Compact and effective photon-resolved image scanning microscope

Giorgio Tortarolo

Fluorescence confocal laser-scanning microscopy (LSM) is one of the most popular tools for life science research. This popularity is expected to grow thanks to single-photon array detectors tailored for LSM. These detectors offer unique single-photon spati ...

Spie-Soc Photo-Optical Instrumentation Engineers2024

PET REBINNING WITH REGULARIZED DENSITY SPLINES

Michaël Unser

PET reconstruction algorithms have long relied on sinogram rebinning. However, as detectors grow smaller in a recent wave of cutting-edge scanners, individual sensors no longer accrue hundreds of photons. Instead, most detect a single photon or none at all ...

IEEE2023

Optical and mid-infrared line emission in nearby Seyfert galaxies

Michaela Hirschmann

Line ratio diagnostics provide valuable clues as to the source of ionizing radiation in galaxies with intense black hole accretion and starbursting events, such as local Seyfert galaxies or galaxies at the peak of their star formation history. We aim to pr ...

2023

Multistage Ion Mobility Spectrometry Combined with Infrared Spectroscopy for Glycan Analysis

Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Priyanka Bansal

The structural complexity of glycans makes their characterization challenging, not only because of the presence of various isomeric forms of the precursor molecule but also because the fragments can themselves be isomeric. We have recently developed an IMS ...

2023

Resolution and penetration depth of reflection-mode time-domain near infrared optical tomography using a ToF SPAD camera

Edoardo Charbon, Jingjing Jiang, Martin Wolf

In a turbid medium such as biological tissue, near-infrared optical tomography (NIROT) can image the oxygenation, a highly relevant clinical parameter. To be an efficient diagnostic tool, NIROT has to have high spatial resolution and depth sensitivity, fas ...

Optica Publishing Group2022

Advanced Techniques in Optical Diffraction Tomography

Ahmed Bassam Sayed Ayoub Mohamed Emam

In this thesis, we study the 3 challenges described above. First, we study different reconstruction techniques and assess the fidelity of each reconstruction results by means of structured illumination and phase conjugation. By reconstructing the 3D refrac ...

EPFL2022

In vitro and in vivo NIR fluorescence lifetime imaging with a time-gated SPAD camera

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

Near-infrared (NIR) fluorescence lifetime imaging (FLI) provides a unique contrast mechanism to monitor biological parameters and molecular events in vivo. Single-photon avalanche diode (SPAD) cameras have been recently demonstrated in FLI microscopy (FLIM ...

Optica Publishing Group2022

Glass-in-glass infiltration for 3D micro-optical composite components

Yves Bellouard, Andreas Mortensen, Jérôme Faist, Enrico Casamenti, Luciano Borasi, Gözden Torun, Mathieu Bertrand

Chalcogenide glass exhibits a wide transmission window in the infrared range, a high refractive index, and nonlinear optical properties; however, due to its poor mechanical properties and low chemical and environmental stability, producing three-dimensiona ...

2022

Nonlinear Inverse Problems in Quantitative Phase Imaging

Thanh-An Michel Pham

The topic of this thesis is the development of new algorithmic reconstruction methods for quantitative phase imaging (QPI). In the past decade, advanced QPI has emerged as a valuable tool to study label-free biological samples and uncover their 3D structur ...

EPFL2022

PHz Electronic Device Design and Simulation for Waveguide-Integrated Carrier-Envelope Phase Detection

Yujia Yang

Carrier-envelope phase (CEP) detection of ultrashort optical pulses and low-energy waveform field sampling have recently been demonstrated using direct time-domain methods that exploit optical-field photoemission from plasmonic nanoantennas. These devices ...

IEEE Institute of Electrical and Electronics Engineers2022

Hybrid Flock - Formation Control Algorithms

Alcherio Martinoli, Cyrill Silvan Baumann, Jonas Perolini, Emna Tourki

Two prominent categories for achieving coordinated multirobot displacement are flocking and navigation in formation. Both categories have their own body of literature and characteristics, including their respective advantages and disadvantages. While typic ...

Springer Nature Switzerland2022

Nanoscale Mapping of Light Emission in Nanospade-Based InGaAs Quantum Wells Integrated on Si(100): Implications for Dual Light-Emitting Devices

Anna Fontcuberta i Morral, Jean-Baptiste Leran, Nicolas Tappy, Nicholas Paul Morgan, Raphaël François Lemerle, Wonjong Kim, Akshay Balgarkashi, Titouan Charvin, Didem Dede, Valerio Piazza

III-V semiconductors outperform Si in many optoelectronics applications due to their high carrier mobility, efficient light emission and absorption processes, and the possibility to engineer their band gap through alloying. However, complementing Si techno ...

2022

High sensitivity, incoherent differential imaging

Chiara Bonati

Microscopic visualisation of optically transparent samples has been a topic of interest for several decades. Features such as density or chemical composition can influence the optical phase of transmitted light, and phase contrast can reveal these structur ...

EPFL2022

Polarization-sensitive optics diffraction tomography

Demetri Psaltis, Ahmed Ayoub, Joowon Lim, Elizabeth Elena Antoine, Amirhossein Saba Shirvan

Polarization of light has been widely used as a contrast mechanism in two-dimensional (2D) microscopy and also in some three-dimensional (3D) imaging modalities. In this paper, we report the 3D tomographic reconstruction of the refractive index (RI) tensor ...

2021

Recent advances in superconducting nanowire single-photon detector technology for exoplanet transit spectroscopy in the mid-infrared

Simone Frasca

The Origins Space Telescope mission concept includes an exoplanet transit spectrometer that requires detector arrays with ultrahigh pixel-to-pixel stability. Superconducting nanowire single-photon detectors, or SNSPDs, have the potential to meet these stri ...

SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS2021