Publications associées à fMRI activation during a language task in adolescents with ASD

Publications associées (36)

Mental State Recognition Deficits Linked to Brain Changes in Parkinson's Disease Without Dementia

Recent studies have reported social cognitive deficits, particularly in emotional processing, in Parkinson's disease (PD). However, a comprehensive characterization of these deficits and their underlying neural correlates remains elusive. Therefore, this s ...

2025

Characterization of language abilities and semantic networks in very preterm children at school-age

Solange Noémie Jeanne Denervaud

It has been widely assessed that very preterm children (

PUBLIC LIBRARY SCIENCE2025

Feature-based encoding of face identity by single neurons in the human amygdala and hippocampus

Emanuela De Falco

Neurons in the human amygdala and hippocampus are classically thought to encode a person’s identity invariant to visual features. However, it remains largely unknown how visual information from higher visual cortical areas is translated into such a semanti ...

2025

Driving and suppressing the human language network using large language models

Martin Schrimpf

Transformer models such as GPT generate human-like language and are predictive of human brain responses to language. Here, using functional-MRI-measured brain responses to 1,000 diverse sentences, we first show that a GPT-based encoding model can predict t ...

Nature Portfolio2024

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

Nagammal Neelagandan

Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 microdeletion, bear no obvious connection to translation. Here, we use proteomics, g ...

Amer Assoc Advancement Science2024

The conceptual foundations of innate immunity: Taking stock 30 years later

Bruno Lemaitre

While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, ...

2024

Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies

Dimitri Nestor Alice Van De Ville, Farnaz Delavari

Psychotic symptoms are among the most debilitating and challenging presentations of severe psychiatric diseases, such as schizophrenia, schizoaffective, and bipolar disorder. A pathophysiological understanding of intrinsic brain activity underlying psychos ...

Frontiers Media Sa2024

Type-Preserving Compilation of Class-Based Languages

Guillaume André Fradji Martres

The Dependent Object Type (DOT) calculus was designed to put Scala on a sound basis, but while DOT relies on structural subtyping, Scala is a fundamentally class-based language. This impedance mismatch means that a proof of DOT soundness by itself is ...

EPFL2023

Towards Novel Evaluation Methods for Social Dialog Systems

Ekaterina Svikhnushina

Language has shaped human evolution and led to the desire to endow machines with language abilities. Recent advancements in natural language processing enable us to achieve this breakthrough in human-machine interaction. However, introducing conversational ...

EPFL2023

A Biallelic Truncating Variant in the TPR Domain of GEMIN5 Associated with Intellectual Disability and Cerebral Atrophy

Nicolas Jean Philippe Guex

GEMIN5 is a multifunctional RNA-binding protein required for the assembly of survival motor neurons. Several bi-allelic truncating and missense variants in this gene are reported to cause a neurodevelopmental disorder characterized by cerebellar atrophy, i ...

2023

Empathetic Conversational Agents for Distress Support

Kalpani Anuradha Welivita

Due to the increasing demands of today's fast-paced world, mental health concerns are on the rise, which necessitates innovative approaches to provide support to those in need. Open-domain conversational agents known as chatbots, offer a unique opportunit ...

EPFL2023

Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia

Erick Jorge Canales Rodriguez

Schizophrenia may represent a trade-off in the evolution of human-specific ontogenetic mechanisms that guide neurodevelopment. Human Accelerated Regions (HARs) are evolutionary markers functioning as neurodevelopmental transcription enhancers that have bee ...

2023

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response

Maria del Carmen Sandi Perez, Dogukan Hazar Ülgen

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct patter ...

2023

CDKL5 sculpts functional callosal connectivity to promote cognitive flexibility

Valerio Zerbi

Functional and structural connectivity alterations in short- and long-range projections have been reported across neurodevelopmental disorders (NDD). Interhemispheric callosal projection neurons (CPN) represent one of the major long-range projections in th ...

SPRINGERNATURE2023

Improved estimation of the risk of manic relapse by combining clinical and brain scan data

Erick Jorge Canales Rodriguez

Introduction: Estimating the risk of manic relapse could help the psychiatrist individually adjust the treatment to the risk. Some authors have attempted to estimate this risk from baseline clinical data. Still, no studies have assessed whether the estimat ...

2023

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

Hirotaka Yamada, Maria del Carmen Sandi Perez, Cristina Ramona Cudalbu Moldovan, Dunja Simicic, Jocelin Grosse

Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high energy demand such as muscle or brain. Creatine is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifi ...

Nature Research2021

“It Is Not the Robot Who Learns, It Is Me.” Treating Severe Dysgraphia Using Child–Robot Interaction

Pierre Dillenbourg, Wafa Monia Benkaouar Johal, Thibault Lucien Christian Asselborn, David Cohen

Writing disorders are frequent and impairing. However, social robots may help to improve children's motivation and to propose enjoyable and tailored activities. Here, we have used the Co-writer scenario in which a child is asked to teach a robot how to wri ...

2021

PARSINLU: A Suite of Language Understanding Challenges for Persian

Rabeeh Karimi Mahabadi

Despite the progress made in recent years in addressing natural language understanding (NLU) challenges, the majority of this progress remains to be concentrated on resource-rich languages like English. This work focuses on Persian language, one of the wid ...

2021

Effects of eight neuropsychiatric copy number variants on human brain structure

Lester Melie Garcia, Borja Rodriguez Herreros

Many copy number variants (CNVs) confer risk for the same range of neurodevelopmental symptoms and psychiatric conditions including autism and schizophrenia. Yet, to date neuroimaging studies have typically been carried out one mutation at a time, showing ...

SPRINGERNATURE2021

Ultrahigh field in vivo characterization of microstructural abnormalities in the orbitofrontal cortex and amygdala in autism

Cristina Granziera, Nouchine Hadjikhani, Elda Fischi Gomez, Guillaume Bonnier

There are currently no biomarkers for autism spectrum disorder (ASD). This neurodevelopmental condition has previously been associated with histopathological findings, including increased neuronal packing density in the amygdala, abnormal laminar cytoarchi ...

2021