Publications associées à Development of an AFM-based nanomotion detection device for microbiological samples

Publications associées (29)

Recent advances in interfacial engineering for high-efficiency perovskite photovoltaics

Through strategies such as process optimization, solvent selection, and component tuning, the crystallization of perovskite materials has been effectively controlled, enabling perovskite solar cells (PSCs) to achieve over 25 % power conversion efficiency ...

2025

Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform

Sandor Kasas, Anthony Vocat

Antimicrobial resistance (AMR) is a major public health threat, reducing treatment options for infected patients. AMR is promoted by a lack of access to rapid antibiotic susceptibility tests (ASTs). Accelerated ASTs can identify effective antibiotics for t ...

Nature Portfolio2024

Homogeneous vs. heterogeneous photo-Fenton elimination of antibiotic-resistant bacteria bearing intracellular or extracellular resistance: Do resistance mechanisms interfere with disinfection pathways?

César Pulgarin, Stefanos Giannakis

The present study aimed to fill the knowledge gap between the implications of intracellular and extracellular antibiotic resistance mechanisms may inflict on the inactivation pathways of the photo-Fenton process under mild conditions. It was thus designed ...

Elsevier Sci Ltd2024

Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction

Camille Véronique Bernadette Goemans, Christian Eugen Zimmerli

Ribosomes translate the genetic code into proteins. Recent technical advances have facilitated in situ structural analyses of ribosome functional states inside eukaryotic cells and the minimal bacterium Mycoplasma. However, such analyses of Gram-negative b ...

Nature Research2024

Machine learning method for the classification of the state of living organisms' oscillations

Sandor Kasas, María Inés Villalba

The World Health Organization highlights the urgent need to address the global threat posed by antibiotic-resistant bacteria. Efficient and rapid detection of bacterial response to antibiotics and their virulence state is crucial for the effective treatmen ...

Frontiers Media Sa2024

Pathobiont and symbiont contribute to microbiota homeostasis through Malpighian tubules–gut countercurrent flow in Bactrocera dorsalis

Bruno Lemaitre

Host–gut microbiota interactions are more complex than good or bad. Both gut symbiotic bacteria and pathobionts can provide essential functions to their host in one scenario and yet be detrimental to host health in another. So, these gut-dwelling bacteria ...

2024

Simple optical nanomotion method for single-bacterium viability and antibiotic response testing

Sandor Kasas, María Inés Villalba

Antibiotic resistance is nowadays a major public health issue. Rapid antimicrobial susceptibility tests (AST) are one of the options to fight this deadly threat. Performing AST with single-cell sensitivity that is rapid, cheap, and widely accessible, is ch ...

National Academy of Sciences2023

Antimicrobial susceptibility testing with integrated photonic crystal optical tweezers

Nicolas Villa

The abusive use of antimicrobial drugs during the last eighty years has favoured the natural selection of resistant pathogens able to neutralise drugs efficiently. Nowadays, antimicrobial resistance contributes to millions of deaths yearly, threatens the e ...

EPFL2023

Creating Trust by Abolishing Hierarchies

Mathias Josef Payer, Edouard Bugnion, Evangelos Marios Kogias, Adrien Ghosn, Charly Nicolas Lucien Castes, Yuchen Qian, Neelu Shivprakash Kalani

Software is going through a trust crisis. Privileged code is no longer trusted and processes insufficiently protect user code from unverified libraries. While usually treated separately, confidential computing and program compartmentalization are both symp ...

Association for Computing Machinery2023

Robust Collaborative Learning with Linear Gradient Overhead

Rachid Guerraoui, Nirupam Gupta, Rafaël Benjamin Pinot, Le Nguyen Hoang, Sadegh Farhadkhani, John Stephan

Collaborative learning algorithms, such as distributed SGD (or D-SGD), are prone to faulty machines that may deviate from their prescribed algorithm because of software or hardware bugs, poisoned data or malicious behaviors. While many solutions have been ...

PLMR2023

Single-Cell Optical Nanomotion of Candida albicans in Microwells for Rapid Antifungal Susceptibility Testing

Sandor Kasas, María Inés Villalba

Candida albicans is an emerging multidrug-resistant opportunistic pathogen representing an important source of invasive disease in humans and generating high healthcare costs worldwide. The development of a rapid and simple antifungal susceptibility test ( ...

MDPI2023

Impact of substrate clogging on vertical connectivity

Giovanni De Cesare, Robin Schroff, Romain Maxime Dubuis

Connectivity between the hyporheic zone and the flow is essential for the development of benthos and the reproductive success of spawning fish. The infiltration of fine sediment leads to clogging of the riverbed, reducing porosity and vertical water exchan ...

2023

Hardware and Software Support for RPC-Centric Server Architecture

Mark Johnathon Sutherland

Online services have become ubiquitous in technological society, the global demand for which has driven enterprises to construct gigantic datacenters that run their software. Such facilities have also recently become a substrate for third-party organizatio ...

EPFL2022

Automated Verification of Network Function Binaries

George Candea, Aikaterini Argyraki, Solal Vincenzo Pirelli

Formally verifying the correctness of software network functions (NFs) is necessary for network reliability, yet existing techniques require full source code and mandate the use of specific data structures. We describe an automated technique to verify NF b ...

USENIX Association2022

Simulating time-varying strong lenses

Georgios Vernardos

We present a self-consistent and versatile forward modelling software package that can produce time series and pixel-level simulations of time-varying strongly lensed systems. The time dimension, which needs to take into account different physical mechanis ...

OXFORD UNIV PRESS2022

Identification of genes required for host-cell adhesion and antibiotic persistence of uropathogenic Escherichia coli via high-content screening

Thomas Marie Simonet

Uropathogenic Escherichia coli (UPEC) are the most common bacterial pathogens causing urinary tract infections (UTIs). Driven by the development of antibiotic resistant UPEC strains, UTIs have become a major public health issue and generate substantial hea ...

EPFL2022

In vitro synergistic action of TAT-RasGAP 317-326 peptide with antibiotics against Gram-negative pathogens

Grazia Vizzarro

Objectives: Multidrug-resistant (MDR) bacteria are a continuously increasing threat for medicine, caus-ing infections recalcitrant to antibiotics. Antimicrobial peptides (AMPs) were identified as alternatives to antibiotics, being naturally occurring short ...

2022

The Dynamics of Single-Cell Nanomotion Behaviour of Saccharomyces cerevisiae in a Microfluidic Chip for Rapid Antifungal Susceptibility Testing

Sandor Kasas, María Inés Villalba

The fast emergence of multi-resistant pathogenic yeasts is caused by the extensive-and sometimes unnecessary-use of broad-spectrum antimicrobial drugs. To rationalise the use of broad-spectrum antifungals, it is essential to have a rapid and sensitive syst ...

MDPI2022

Microfabricated nanomotion detectors for rapid cells viability tests

Anton Malovichko

The widespread use of antibiotics and antifungal drugs has provoked an increasing number of multi-resistant bacteria and fungi. The emergence of multiresistance to antibiotics has been now recognized as a very serious public health issue. In order to targe ...

EPFL2021

Photodynamic treatment of multidrug-resistant bacterial infection using indium phosphide quantum dots

Francesco Stellacci

Infections caused by multidrug-resistant (MDR) bacteria pose an impending threat to humanity, as the evolution of MDR bacteria outpaces the development of effective antibiotics. In this work, we use indium phosphide (InP) quantum dots (QDs) to treat infect ...

ROYAL SOC CHEMISTRY2022