Publications associées à Strategies to Functionalize the Anionic Biopolymer Na-Alginate Without Restricting its Polyelectrolyte Properties

Localized Ionic Reinforcement of Double Network Granular Hydrogels

Nature produces soft materials with fascinating combinations of mechanical properties. For example, the mussel byssus embodies a combination of stiffness and toughness, a feature that is unmatched by synthetic hydrogels. Key to enabling these excellent mec ...

Wiley-V C H Verlag Gmbh2024

Valence can control the nonexponential viscoelastic relaxation of multivalent reversible gels

Hugo Camille Valentin Le Roy

Gels made of telechelic polymers connected by reversible cross-linkers are a versatile design platform for biocompatible viscoelastic materials. Their linear response to a step strain displays a fast, near-exponential relaxation when using low-valence cros ...

Amer Assoc Advancement Science2024

Rheological Properties of Ionically Crosslinked Viscoelastic 2D Films vs. Corresponding 3D Bulk Hydrogels

Esther Amstad, Gaia De Angelis

Ionically crosslinked hydrogels containing metal coordination motifs have piqued the interest of researchers in recent decades due to their self-healing and adhesive properties. In particular, catechol-functionalized bulk hydrogels have received a lot of a ...

AMER CHEMICAL SOC2023

Mechanical Reinforcement of Hydrogels through Physical Crosslinks and Double Network Granular Architecture

Alvaro Lino Boris Charlet

Throughout nature, organisms fabricate a myriad of materials to sustain their lifestyle. Many of the soft materials are composed of water-swollen networks of organic molecules, so-called hydrogels. They generally contribute to the mechanical integrity of t ...

EPFL2022

Revisiting Cation Complexation and Hydrogen Bonding of Single-Chain Polyguluronate Alginate

Modifying the properties of bio-based materials has garnered increasing interest in recent years. In related applications, the ability of alginates to complex with metal ions has been shown to be effective in liquid-to-gel transitions, useful in the develo ...

American Chemical Society2021

Shape retaining self-healing metal-coordinated hydrogels

Raffaele Mezzenga, Alvaro Lino Boris Charlet, Esther Amstad

Metal-coordinated hydrogels are physical hydrogels entirely crosslinked by complexes between ligand decorated polymers and metal ions. The mechanical properties of these hydrogels strongly depend on the density and dynamics of metal-coordinated interaction ...

2021

Multifunctional hybrid alginate-based hydrogels for cell immobilization

Luca Szabó

Cell therapy could be a solution for many diseases that currently pose a huge health burden on patients. Especially, cell therapies based on cell microencapsulation are of great interest. Immunoprotection of cells would allow to avoid the need for immunosu ...

EPFL2020

Development of functionalized alginate-based hydrogels to reduce fibrosis in the transplantation of microencapsulated cells

François Rémi Pierre Noverraz

Nowadays, the development of cell therapy relies mainly on the advances made toward cell microencapsulation which allows to evade the need for immunosuppression during cell transplantation. Among the materials considered for cell encapsulation, hydrogels d ...

EPFL2018

Composite Double-Network Hydrogels To Improve Adhesion on Biological Surfaces

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser, Céline Samira Wyss, Martin Broome, Peyman Karami

Despite the development of hydrogels with high mechanical properties, insufficient adhesion between these materials and biological surfaces significantly limits their use in the biomedical field. By controlling toughening processes, we designed a composite ...

2018

Equilibrium and Out-of-Equilibrium Adherence of Hydrogels against Polymer Brushes

Costantino Creton, Jennifer Mary Adrienne Alice Macron

At low pH, underwater adherence between poly(N,N-dimethylacrylamide) hydrogels and poly(acrylic acid) brushes is due to the formation of multiple hydrogen bonds. The effect of the key parameters controlling the formation of these interactions (contact time ...

American Chemical Society2018

Synthesis strategies to extend the variety of alginate-based hybrid hydrogels for cell microencapsulation

Jutta Christine Wandrey, Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard, Luca Szabó

The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic p ...

American Chemical Society2017

Nano Fibrillated Cellulose Based Composite Hydrogels for an Injectable Intervertebral Disc Implant

Azadeh Khoushabi

Replacing the gel-like central part of the intervertebral disc (IVD), so-called nucleus pulposus (NP), via a minimally invasive surgery is one of the most recent approaches in the lower back pain treatments. An appropriate biomaterial for NP replacement (N ...

EPFL2016

Functionalized Ionic (Poly)Styrenes and their Application as Catalysts in the Cycloaddition of CO2 to Epoxides

Rosario Scopelliti, Paul Joseph Dyson, Zhaofu Fei, Felix Daniel Bobbink, Shoubhik Das

Valorization of CO2, an abundant C(1) synthon, into platform chemicals is of growing interest. In this context, a key reaction is the cycloaddition of CO2 to epoxides to form carbonates (CCE). A series of organocatalysts for this reaction, based on imidazo ...

Wiley-Blackwell2016

Tuning the Properties of Hydrogel Microspheres by Adding Chemical Cross-linking Functionality to Sodium Alginate

Jutta Christine Wandrey, Sandrine Gerber, Redouan Mahou, Françoise Borcard, Léo Bühler, François Rémi Pierre Noverraz, Virginia Crivelli, Solène Marcelle Françoise Marie Passemard

Two novel types of hydrogel microspheres (MS) are presented. First, one-component microspheres (1-comMS) were produced from sodium alginate (Na-alg) equipped with thiolfunctionalized hydroxyl groups. The functionalization pathway included the conversion of ...

American Chemical Society2015

Microfluidic patterning of alginate hydrogels

Philippe Renaud

In this article the authors present techniques which allow the microfluidic design of alginate microgels with layer composition on a chip. The hydrogel is created by combining two laminar flows of the gel precursor solutions-a calcium solution and an algin ...

American Vacuum Society2007

Alginate-based microcapsules for mammalian cell culture and other biotechnological applications

Véronique Breguet

Since life began, nature has been using the envelopment of systems for their protection or for providing a particular reaction space, the enveloping wall displaying additional specific membrane functions. The abundance of examples is quite overwhelming and ...

EPFL2007

Gentle cell trapping and release on a microfluidic chip by in situ alginate hydrogel formation

Philippe Renaud, Lynda Metref, Thomas Michael Braschler

Microfluidic devices are increasingly used to perform biological experiments on a single-cell basis. However, long-term stability of cell positions is still an issue. A novel biocompatible method for cell entrapment and release on a microchip is presented. ...

2005