Corticospinal neuroprostheses to restore locomotion after spinal cord injury

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Neural organoids and spheroids are three-dimensional (3D) in vitro brain models that mimic key aspects of human brain cellular composition, organization, and function. These models have become essential for studying brain development and neurological disor ...

Plasma shape control is a fundamental tool for effective tokamak operation, allowing improved plasma performance and the pursuit of challenging scientific objectives. In this framework, the Tokamak á Configuration Variable (TCV) of the École Polytechnique ...

Neuroprostheses have been used clinically for decades, to help restore or preserve brain functions, when pharmaceutical treatments are inefficient. Although great progress in the field has been made over the years to interface with the nervous system, surf ...

Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to ...

Electrical stimulation of the nervous system has emerged as a promising assistive technology in case of many injuries and illnesses across various parts of the nervous system. In particular, the invasive neuromodulation of the peripheral nervous system see ...

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

This thesis presents an extensive exploration of neuroelectronic interfaces, focusing on microfabrication, in silico modeling, and their applications in designing and fabricating devices for neural interfacing. The research encompasses both peripheral nerv ...

Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve a ...

Implanted medical devices (IMDs) have been widely developed to support the monitoring and recording of biological data inside the body or brain. Wirelessly powered IMDs, a subset of implantable electronics, have been proposed to eliminate the limitations r ...

Objective. Selective neuromodulation of deep brain regions has for a long time only been possible through invasive approaches, because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques. Approach. An appr ...

Animals, including humans, exhibit a remarkable variety of complex behaviours. How the nervous system controls all these behaviours ranging from simple, stereotyped movements to flexible, adaptive actions is a central questions of neuroscience. One of the ...

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...

Recently, cutting-edge brain-machine interfaces (BMIs) have revealed the potential of decoders such as recurrent neural networks (RNNs) in predicting attempted handwriting [1] or speech [2], enabling rapid communication recovery after paralysis. However, c ...

Background :Sensory reafferents are crucial to correct our posture and movements, both reflexively and in a cognitively driven manner. They are also integral to developing and maintaining a sense of agency for our actions. In cases of compromised reafferen ...

A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

Over the past decade, there has been a growing interest in the development of intelligent neural interface systems-on-chip (SoCs) for a range of neurological disorders and emerging brain-machine interface (BMI) applications. The shift toward creating intel ...

The present invention relates to a neuromodulation/neurostimulation system (10) for stimulating at least one neuronal circuitry responsible for micturition control in a mammal with bladder disfunction, especially for bladder relaxation and/or for bladder v ...

Transformer models such as GPT generate human-like language and are predictive of human brain responses to language. Here, using functional-MRI-measured brain responses to 1,000 diverse sentences, we first show that a GPT-based encoding model can predict t ...

Electrical stimulation of the visual nervous system could improve the quality of life of patients affected by acquired blindness by restoring some visual sensations, but requires careful optimization of stimulation parameters to produce useful perceptions. ...

This article summarizes the recent advancements in the design, fabrication, and control of microrobotic devices for the diagnosis and treatment of brain disorders. With a focus on diverse actuation methods, we discuss how advancements in materials science ...

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

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Soft microelectrode arrays for 3D in vitro brain models

Design and implementation of a model-based hierarchical architecture for plasma shape control in the TCV tokamak

Unraveling behavior and cortical signals to guide the development of soft neuroprostheses for auditory restoration and spreading depolarization

Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Multimodal transcriptomic atlases of mouse spinal cord injury

Modeling, fabrication and validation of 3D neural interfaces for peripheral nerves and brain organoids

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

Integrated Wireless Power, Data Communication, and Thermal Sensing System for Autonomous Multisite Brain Implants

Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions

Uncovering interactions between Descending Neurons as a functional principle of behavioural control

System for control of spasticity

33.3 MiBMI: A 192/512-Channel 2.46mm² Miniaturized Brain-Machine Interface Chipset Enabling 31-Class Brain-to-Text Conversion Through Distinctive Neural Codes

Augmenting locomotor perception by remapping tactile foot sensation to the back

A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Intelligent Neural Interfaces: An Emerging Era in Neurotechnology

System for micturition control in a mammal with bladder disfunction

Driving and suppressing the human language network using large language models

Decoding electroencephalographic responses to visual stimuli compatible with electrical stimulation

Small-scale robotic devices for medical interventions in the brain