KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

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Publications associées (32)

The Magnificent Five Images of Supernova Refsdal: Time Delay and Magnification Measurements

Vivien François Bonvin, Martin Raoul Robert Millon, Mathilde Jauzac, Anja Von der Linden

In late 2014, four images of Supernova (SN) "Refsdal," the first known example of a strongly lensed SN with multiple resolved images, were detected in the MACS J1149 galaxy-cluster field. Following the images' discovery, the SN was predicted to reappear wi ...

IOP Publishing Ltd2023

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Sebastian Maerkl, Ivan Istomin, Evan James Olson, Shiyu Cheng, Amir Shahein, Maria Lopez Malo

Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in vitro and found that transcription fac ...

Nature Portfolio2022

Dark matter in galaxy clusters: Parametric strong-lensing approach

Benjamin Emmanuel Nicolas Beauchesne

We present a parametric strong-lensing analysis of three massive galaxy clusters for which Hubble Space Telescope imaging is available, as well as spectroscopy of multiply imaged systems and galaxy cluster members. Our aim is to probe the inner shape of da ...

EDP SCIENCES S A2022

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools

Henning Paul-Julius Stahlberg, Dongchun Ni

Type I CRISPR-Cas systems typically rely on a two-step process to degrade DNA. First, an RNA-guided complex named Cascade identifies the complementary DNA target. The helicase-nuclease fusion enzyme Cas3 is then recruited in trans for processive DNA degrad ...

CELL PRESS2022

Virgo Filaments. II. Catalog and First Results on the Effect of Filaments on Galaxy Properties

Pascale Jablonka, Gianluca Castignani

Virgo is the nearest galaxy cluster; it is thus ideal for studies of galaxy evolution in dense environments in the local universe. It is embedded in a complex filamentary network of galaxies and groups, which represents the skeleton of the large-scale Lani ...

IOP Publishing Ltd2022

Do the majority of stars form as gravitationally unbound?

Richard Irving Anderson

Context. Some of the youngest stars (age less than or similar to 10 Myr) are clustered, while many others are observed scattered throughout star forming regions or in complete isolation. It has been intensively debated whether such scattered or isolated st ...

2022

A stellar stream remnant of a globular cluster below the metallicity floor

Pascale Jablonka, Carmela Lardo

Stellar ejecta gradually enrich the gas out of which subsequent stars form, making the least chemically enriched stellar systems direct fossils of structures formed in the early Universe(1). Although a few hundred stars with metal content below 1,000th of ...

NATURE PORTFOLIO2022

An optimized high throughput platform, from genetic transformation to fermentation, to screen for secreted laccases in Aspergillus niger

Laure Marie Colette Leynaud-Kieffer Curran

Many challenges are faced in the conversion of biomass into advanced biofuels, one of which is finding the correct organism for the job. The filamentous fungus Aspergillus niger has been chosen as a biocatalyst for cellulose, hemicellulose, and lignin degr ...

EPFL2021

Nuclear star cluster formation in star-forming dwarf galaxies

Oliver Müller

Nuclear star clusters (NSCs) are massive star clusters found in all types of galaxies from dwarfs to massive galaxies. Recent studies show that while low-mass NSCs in dwarf galaxies (M-gal< 10(9)M(circle dot)) form predominantly out of the merger of globul ...

EDP SCIENCES S A2022

Geographic clusters of objectively measured physical activity and the characteristics of their built environment in a Swiss urban area

Stéphane Joost, Cédric Gubelmann, Marco André Vieira Ruas, Idris Guessous

Introduction ...

PUBLIC LIBRARY SCIENCE2022

Systematic analysis of biomolecular binding reactions using microfluidic systems

Amir Shahein

Transcription factor binding to a single binding site on DNA and its functional consequence in a promoter context are beginning to be relatively well understood. However, binding to clusters of sites has yet to be characterized in depth, and the functional ...

EPFL2022

Binary Perceptron: Efficient Algorithms Can Find Solutions in a RareWell-Connected Cluster

Emmanuel Abbé

It was recently shown that almost all solutions in the symmetric binary perceptron are isolated, even at low constraint densities, suggesting that finding typical solutions is hard. In contrast, some algorithms have been shown empirically to succeed in fin ...

ASSOC COMPUTING MACHINERY2022

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