Publications associées à A Compressed Sensing Framework for Magnetic Resonance Fingerprinting

Robust gamma-aminobutyric acid and energy metabolism measurements by proton and phosphorus magnetic resonance spectroscopy and fingerprinting

Magnetic resonance spectroscopy (MRS) is the only technique that can detect endogenous metabolites directly and non-invasively in vivo. It allows to identify different metabolites and analyze the dynamic neurochemical processes in the brain, skeletal muscl ...

EPFL2023

Imaging Radial Distribution Functions of Complex Particles by Relayed Dynamic Nuclear Polarization

Arthur César Pinon, David Lyndon Emsley, Pierrick Berruyer

The physical properties of many modern multi-component materials are determined by their internal microstructure. Tools capable of characterizing complex nanoscale architectures in composite materials are, therefore, essential to design materials with targ ...

2023

Diamond-Based Nanoscale Quantum Relaxometry for Sensing Free Radical Production in Cells

Hoda Shirzad, Mayeul Sylvain Chipaux

Diamond magnetometry makes use of fluorescent defects in diamonds to convert magnetic resonance signals into fluorescence. Because optical photons can be detected much more sensitively, this technique currently holds several sensitivity world records for r ...

WILEY-V C H VERLAG GMBH2022

Quantitative Microstructural Imaging for Clinical Use

Gian Franco Piredda

Today, Magnetic Resonance Imaging (MRI) is a well-established medical imaging modality thanks to its excellent soft tissue contrast. Conventional MR image contrasts can be weighted towards one or more physical properties that discriminate different tissues ...

EPFL2021

Multiple sclerosis cortical and WM lesion segmentation at 3T MRI: a deep learning method based on FLAIR and MP2RAGE

Jean-Philippe Thiran, Meritxell Bach Cuadra, Ahmed Abdulkadir, Cristina Granziera, Mario Joao Fartaria de Oliveira, Po-Jui Lu, Muhamed Barakovic, Francesco La Rosa

The presence of cortical lesions in multiple sclerosis patients has emerged as an important biomarker of the disease. They appear in the earliest stages of the illness and have been shown to correlate with the severity of clinical symptoms. However, cortic ...

2020

Nanodiamond Relaxometry-Based Detection of Free-Radical Species When Produced in Chemical Reactions in Biologically Relevant Conditions

Mayeul Sylvain Chipaux

Diamond magnetometry is a quantum sensing method involving detection of magnetic resonances with nanoscale resolution. For instance, T1 relaxation measurements, inspired by equivalent concepts in magnetic resonance imaging (MRI), provide a signal that is e ...

AMER CHEMICAL SOC2020

Towards quantitative brain connectomics: microstructure informed tractography via convex optimization

Muhamed Barakovic

Tractography is the only non-invasive technique which is used to reconstruct the white mat- ter structural connectivity of the human brain. It relies on a specific Magnetic Resonance Imaging (MRI) acquisition, called diffusion MRI, which is sensitive to th ...

EPFL2019

Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS

Lijing Xin, Yuhei Takado

Both glutamine (Gln) and glutamate (Glu) are known to exist in plasma and brain. However, despite the assumed relationship between brain and plasma, no studies have clarified the association between them. Proton magnetic resonance spectroscopy (MRS) was se ...

2019

Data-driven Measurement Designs for Magnetic Resonance Imaging

Baran Gözcü

Despite being a powerful medical imaging technique which does not emit any ionizing radiation, magnetic resonance imaging (MRI) always had the major problem of long scanning times that can take up to an hour depending on the application. It also requires u ...

EPFL2019

Development and Optimization of Methods for Accelerated Magnetic Resonance Imaging

Tom Hilbert

Magnetic resonance imaging (MRI) has yielded great success as a medical imaging modality in the past decades, and its excellent soft tissue contrast is used in clinical routine to support diagnosis today. However, MRI is still facing challenges. For exampl ...

EPFL2018

Study of fast exchanging processes by NMR Spectroscopy

Estel Canet Martinez

Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful and informative methods to probe molecular dynamics. Specifically, chemical exchange is an important phenomenon and one of the earliest and most vigorously investigated in NMR spectr ...

EPFL2017

Methods and microfabrication techniques for subnanoliter magnetic resonance spectroscopy

Enrica Montinaro

Nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR) and ferromagnetic resonance (FMR) spectroscopy can open up the possibility of studying many scientifically and biologically relevant samples at the µm and sub-µm scale. Examples of vol ...

EPFL2017

Long-lived nuclear spin states of magnetically equivalent protons by means of dissolution dynamic nuclear polarization

Daniele Mammoli

Nuclear Magnetic Resonance (NMR) is one of the most versatile techniques since it enables the characterization of solid, liquid and gaseous systems in a plethora of in-vitro and in-vivo experiments. Despite its multidisciplinary scope, it still suffers fro ...

EPFL2016

Producing Radical-Free Hyperpolarized Perfusion Agents for In Vivo Magnetic Resonance Using Spin-Labeled Thermoresponsive Hydrogel

Arnaud Comment, Mor-Miri Mishkovsky, Tian Cheng

Dissolution dynamic nuclear polarization (DNP) provides a way to tremendously improve the sensitivity of nuclear magnetic resonance experiments. Once the spins are hyperpolarized by dissolution DNP, the radicals used as polarizing agents become undesirable ...

Wiley-Blackwell2016

Challenges in preparing, preserving and detecting para-water in bulk: overcoming proton exchange and other hurdles

Geoffrey Bodenhausen, Sami Jannin, Aurélien Bornet, Jonas Milani, Nicola Salvi, Diego Carnevale, Roberto Buratto, Daniele Mammoli, Estel Canet Martinez

Para-water is an analogue of para-hydrogen, where the two proton spins are in a quantum state that is antisymmetric under permutation, also known as singlet state. The populations of the nuclear spin states in para-water are believed to have long lifetimes ...

Royal Society of Chemistry2015

De l'usage des protons hyperpolarisés pour augmenter la sensibilité de la RMN

Aurélien Bornet

Nuclear Magnetic Resonance (NMR) has become an inescapable technique for spectroscopic identification. Its main advantage comes from the sensitivity of NMR active nuclei embedded in a molecule to their chemical environment. NMR is also used daily in medica ...

EPFL2015

Compressed Quantitative MRI: Bloch Response Recovery through iterated projection

Pierre Vandergheynst, Yves Wiaux, Gilles Puy

Inspired by the recently proposed Magnetic Resonance Fin- gerprinting technique, we develop a principled compressed sensing framework for quantitative MRI. The three key com- ponents are: a random pulse excitation sequence following the MRF technique; a ra ...

2014

Decoupling of Magnetic Resonance Signals in Time and Frequency Domain

Nuclear magnetic resonance (NMR) was discovered in the first half of the 20th century. Today, neither analytical chemistry without NMR spectroscopy nor medical diagnostics without magnetic resonance imaging (MRI) could be imagined. A magnetic resonance sig ...

EPFL2013

Magnetization transfer-based 3D visualization of foot peripheral nerves

Giulio Gambarota, Bénédicte Marie Maréchal, Gunnar Krüger, Cristina Granziera

PURPOSE: To investigate magnetization transfer (MT) effects as a new source of contrast for imaging and tracking of peripheral foot nerves. MATERIALS AND METHODS: Two sets of 3D spoiled gradient-echo images acquired with and without a saturation pulse were ...

Wiley-Blackwell2013

Nanosecond Time Scale Motions in Proteins Revealed by High-Resolution NMR Relaxometry

Geoffrey Bodenhausen, Fabien Ferrage

Understanding the molecular determinants underlying protein function requires the characterization of both structure and dynamics at atomic resolution. Nuclear relaxation rates allow a precise characterization of protein dynamics at the Larmor frequencies ...

American Chemical Society2013