Virucidal compounds and uses thereof

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Publications associées (30)

Inhibition of influenza virus activity by the bovine seminal plasma protein PDC-109

Christian Sieben

A number of viruses causing sexually transmissible diseases are transmitted via mammalian seminal plasma. Several components of seminal plasma have been shown to influence those viruses and their physiological impact. To unravel whether components of semin ...

SPRINGER2019

Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

Jacques Fellay, Nimisha Chaturvedi

Genetic polymorphism in the interferon lambda (IFN-lambda) region is associated with spontaneous clearance of hepatitis C virus (HCV) infection and response to interferon-based treatment. Here, we evaluate associations between IFN-l polymorphism and HCV va ...

2019

Safely Managed Hygiene: A Risk-Based Assessment of Handwashing Water Quality

Timothy R. Julian, Matthew Eric Verbyla

Sustainable Development Goal (SDG) Indicator 6.2.1 requires household handwashing facilities to have soap and water, but there are no guidelines for handwashing water quality. In contrast, drinking water quality guidelines are defined: water must be "free ...

2019

E-coli-MS2 bacteriophage interactions during solar disinfection of wastewater and the subsequent post-irradiation period

César Pulgarin, Margaux Océane Voumard, Stefanos Giannakis, Anna Carratala Ripolles

In this study, the effect of MS2 bacteriophage on the inactivation of its Escherichia coli host was evaluated in an effort to recreate some the main factors governing solar disinfection of wastewater (namely microbial growth, infection, photonic flux). As ...

ELSEVIER SCIENCE SA2019

Virucidal metallic nanoparticles and uses thereof

Francesco Stellacci, Valeria Cagno

The invention relates to virucidal metallic nanoparticles, virucidal compositions comprising thereof and uses thereof in treatment and/or prevention of viral infections, for sterilizations and for disinfections. ...

2018

Interferon lambda 3/4 polymorphisms are associated with AIDS-related Kaposi's sarcoma

Patrick Taffe, Jacques Fellay

Background: Kaposi's sarcoma, the most common AIDS-related cancer, represents a major public concern in resource-limited countries. Single nucleotide polymorphisms within the Interferon lambda 3/4 region (IFNL3/4) determine the expression, function of IFNL ...

LIPPINCOTT WILLIAMS & WILKINS2018

Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota

Nicola Harris, Benjamin John Marsland, Eva Sabrina Gollwitzer

BACKGROUND: Helminth parasites have been reported to have beneficial immunomodulatory effects in patients with allergic and autoimmune conditions and detrimental consequences in patients with tuberculosis and some viral infections. Their role in coinfectio ...

Elsevier2017

Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein

Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Marcela Rincón-Restrepo, Clara Galan Navarro, Stefan Kunz

Lassa virus (LASV) causes severe hemorrhagic fever with high mortality, yet no vaccine currently exists. Antibodies targeting viral attachment proteins are crucial for protection against many viral infections. However, the envelope glycoprotein (GP) 1 of L ...

Academic Press Inc Elsevier Science2017

Broad-spectrum Antiviral Nanoparticles : a morphological CryoEM Study on the Interaction of Nanoparticles and Viruses

Marie Müller

Viral infections affect millions of people every year, yet broad-spectrum virucidal therapies are not available. Antiviral substances in current use act on specific viral mechanisms against only a small number of viruses. Virustatic materials interfere wit ...

EPFL2017

Characterizing human cytomegalovirus reinfection in congenitally infected infants: an evolutionary perspective

Jeffrey David Jensen, Cornelia Pokalyuk, Kristen Kay Irwin, Susanne Petra Pfeifer

Given the strong selective pressures often faced by populations when colonizing a novel habitat, the level of variation present on which selection may act is an important indicator of adaptive potential. While often discussed in an ecological context, this ...

Wiley2017

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