Pore Size Manipulation in 3D Printed Cryogels Enables Selective Cell Seeding

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3D Printing of Strong and Tough Double Network Granular Hydrogels

Esther Amstad, Matteo Hirsch, Alvaro Lino Boris Charlet

Many soft natural tissues display a fascinating set of mechanical properties that remains unmatched by manmade counterparts. These unprecedented mechanical properties are achieved through an intricate interplay between the structure and locally varying the ...

2020

Implementation of Functional Microfluidic Dispensing Tools Enabling Enhanced Control in Extrusion Bioprinting

Ludovic Serex

Inspired from additive manufacturing's success, the structuring of biocompatible materials through bioprinting has become a growing field of research in the past fifteen years. It opened the door to a plethora of applications ranging from the fabrication o ...

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Volumetric Bioprinting of Complex Living-Tissue Constructs within Seconds

Christophe Moser, Damien Claude-Marie Loterie, Paul Delrot, Yang Li

Biofabrication technologies, including stereolithography and extrusion-based printing, are revolutionizing the creation of complex engineered tissues. The current paradigm in bioprinting relies on the additive layer-by-layer deposition and assembly of repe ...

Wiley2019

Elastomer-based pneumatic device to measure the mechanical properties of cell monolayers

Francesca Sorba

Everyday life physiological functions such as breathing, muscle contraction, and blood circulation rely on the ability of single cells to organize into higher complexity structures and sustain mechanical deformations. Cell monolayers are the simplest tissu ...

EPFL2019

Engineered peptide macrocycles can inhibit matrix metalloproteinases with high selectivity

Christian Heinis, Xudong Kong, Jonas Alfred Karl Wilbs, Kaycie Marie Butler, Jeremy Touati, Maola Khan Mohammad Golam, Michal Sabisz

Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases at the intersection of health and disease due to their involvement in processes such as tissue repair and immunity as well as cancer and inflammation. Because of the high structural conserv ...

2019

Engineering Dynamic Hydrogels For In Vitro Organoid Culture

Delphine Lorraine Perle Blondel

Over the past decade, methods to culture stem cells in three dimensions have opened up a plethora of new opportunities for basic and translational research in the life sciences. In particular, the use of natural extracellular matrix (ECM) surrogates, such ...

EPFL2019

Engineering a stable future for DNA-origami as a biomaterial

Maartje Martina Cornelia Bastings, Eva Eugene Kurisinkal, Hale Bila

DNA as a biomaterial has evoked great interest as a potential platform for therapeutics and diagnostics and as hydrogel scaffolds due to the relative ease of programming its robust and uniform shape, site-specific functionality and controlled responsive be ...

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Crystal Orientation Drives the Interface Physics at Two/Three-Dimensional Hybrid Perovskites

Mohammad Khaja Nazeeruddin, Jacques-Edouard Moser, Giulia Grancini, Sanghyun Paek, Kyung Taek Cho, Cristina Roldán Carmona, Valentin Ianis Emmanuel Queloz, Marine Eva Fedora Bouduban

Combining halide perovskites with tailored dimensionality into two/three-dimensional (2D/3D) systems has revealed a powerful strategy to boost the performances of perovskite photovoltaics (PVs). Despite recent advances, a clear understanding of the intimat ...

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Additive manufacturing of hierarchical injectable scaffolds for tissue engineering

Philippe Renaud, Niccolo Piacentini, Thomas Michael Braschler

We present a 3D-printing technology allowing free-form fabrication of centimetre-scale injectable structures for minimally invasive delivery. They result from the combination of 3D printing onto a cryogenic substrate and optimisation of carboxymethylcellul ...

2018