New melphalan derivatives for the treatment of retinoblastoma in combination with thermotherapy

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Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion assays

Philippe Renaud, Arnaud Bertsch, Clémentine Sophie Sarah Lipp

The understanding of cell-cell and cell-matrix interactions via receptor and ligand binding relies on our ability to study the very first events of their contact. Of particular interest is the interaction between a T cell receptor and its cognate peptide-m ...

ROYAL SOC CHEMISTRY2023

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Bruno Emanuel Ferreira De Sousa Correia, Li Tang, Pablo Gainza Cirauqui, Sandrine Madeleine Suzanne Georgeon, Stéphane Rosset, Leo Scheller, Anthony Marchand, Sailan Shui, Lucia Bonati

Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...

2023

Traceable impedance-based single-cell pipetting, from a research set-up to a robust and fast automated robot: DispenCell-S1

Philippe Renaud, Audrey Véronique Berger

Single-cell isolation is a truly transformative tool for the understanding of biological systems. It allows single-cell molecular analyses and considers the heterogeneity of cell populations, which is of particular relevance for the diagnosis and treatment ...

ELSEVIER SCIENCE INC2022

Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes

Rosario Scopelliti

A series of Cu(diimine)(X-sal)(NO3) complexes, where the diimine is either 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) and X-sal is a monoanionic halogenated salicylaldehyde (X = Cl, Br, I, or H), have been synthesized and characterized by elementa ...

AMER CHEMICAL SOC2020