LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

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Background and hypothesis: Redox dysregulation has been proposed as a convergent point of childhood trauma and the emergence of psychiatric disorders, such as schizophrenia (SCZ). A critical region particularly vulnerable to environmental insults during ad ...

Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...

Background: Sleep deprivation causes hippocampal injury, manifesting as neuronal damage and learning-memory impairment. These negative effects may be associated with disturbance of hippocampal glutamate and water homeostasis, which induces excessive neuron ...

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

The adaptation of organisms to their environment depends on the innovative potential inherent to genetic variation. In complex organisms such as mammals, processes like development and immunity require tight gene regulation. Complex forms emerge more often ...

Analysis of single-cell datasets generated from diverse organisms offers unprecedented opportunities to unravel fundamental evolutionary processes of conservation and diversification of cell types. However, interspecies genomic differences limit the joint ...

Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly mani ...

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Emotion recognition through artificial intelligence and smart sensing of physical and physiological signals (affective computing) is achieving very interesting results in terms of accuracy, inference times, and user-independent models. In this sense, there ...

The cell cycle-regulated DNA methyltransferase CcrM is conserved in most Alphaproteobacteria, but its role in bacteria with complex or multicentric genomes remains unexplored. Here, we compare the methylome, the transcriptome and the phenotypes of wild-typ ...

Protein–ligand interactions (PLIs) determine the efficacy and safety profiles of small molecule drugs. Existing methods rely on either structural information or resource-intensive computations to predict PLI, casting doubt on whether it is possible to perf ...

Growing evidence indicates that transposable elements (TEs) play important roles in evolution by providing genomes with coding and non-coding sequences. Identification of TE-derived functional elements, however, has relied on TE annotations in individual s ...

Background: Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes from early embryo- genesis to innate ...

Objectives The endosymbiosis with Symbiodiniaceae is key to the ecological success of reef-building corals. However, climate change is threatening to destabilize this symbiosis on a global scale. Most studies looking into the response of corals to heat str ...

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

Experimental measurements of the turbulence amplitude utilizing a short pulse reflectometry method are presented. Two discharges with shaped plasma possessing opposite signs of triangularity are considered and a higher turbulence amplitude is found in the ...

Light-controlled transcriptional activation is a commonly used optogenetic strategy that allows researchers to regulate gene expression with high spatiotemporal precision. The vast majority of existing tools are, however, limited to light-triggered inducti ...

A central role of brain mitochondria in regulating and influencing social behaviour is emerging. In addition to its important roles as the "powerhouses" of the cell, mitochondria possess a plethora of cellular functions, such as regulating ion homeostasis, ...

High-throughput transcriptomics is of increasing fundamental biological and clinical interest. The generation of molecular data from large collections of samples, such as biobanks and drug libraries, is boosting the development of new biomarkers and treatm ...

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

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Adolescent Stress-Induced Ventral Hippocampus Redox Dysregulation Underlies Behavioral Deficits and Excitatory/Inhibitory Imbalance Related to Schizophrenia

Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

Five percent CO2 inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Meeting our Makers: Uncovering the cis-regulatory activity of transposable elements using statistical learning

Toward universal cell embeddings: integrating single-cell RNA-seq datasets across species with SATURN

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Personalized Clustering for Emotion Recognition Improvement

DNA methylation by CcrM contributes to genome maintenance in the Agrobacterium tumefaciens plant pathogen

G–PLIP: Knowledge graph neural network for structure-free protein–ligand bioactivity prediction

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Statistical learning quantifies transposable element-mediated cis-regulation

Gene expression of Pocillopora damicornis coral larvae in response to acidification and ocean warming

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

Validation of short-pulse reflectometry turbulence measurements with a synthetic diagnostic

A modular toolbox for the optogenetic deactivation of transcription

Powering the social brain: Mitochondria in social behaviour

Multi-well plate lid for single-step pooling of 96 samples for high-throughput barcode-based sequencing

Principles of Network Plasticity in Neocortical Microcircuits