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Computational fluid dynamics of blood flow in an idealized left human heart

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Publications associées (37)

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A Quasilinear Model for Momentum Transport Including Rotation and Electron-scale Turbulence

Stephan Brunner, Justin Richard Ball, Haomin Sun

In a previous paper, a new gyrokinetic quasilinear model was proposed to study turbulent momentum transport in tokamaks with up-down asymmetric plasma shaping and toroidal flow shear (Sun et al 2024 Nuclear Fusion 64 036026). In this work, we start by appl ...

IOP Publishing Ltd2025

Defining myocardial fiber bundle architecture in atrial digital twins

Alfio Quarteroni

A key component in developing atrial digital twins (ADT) - virtual representations of patients’ atria — is the accurate prescription of myocardial fibers which are essential for the tissue characterization. Due to the difficulty of reconstructing atrial fi ...

2025

Lumped Parameter Modeling of the Hypoplastic Left Heart Syndrome During Birth

Philipp Christoph Weder

Hypoplastic left heart syndrome (HLHS) is a congenital heart disease characterized by the underdevelopment of left heart structures. Previous studies using lumped-parameter models focused on extreme cases where the left ventricle is absent. We propose a mo ...

Springer Science and Business Media Deutschland GmbH2025

Minimally Invasive and in Situ Capacitive Sensing of Cardiac Troponin I From Interstitial Fluid

Hadi Mirzajani

Current diagnostic approaches for myocardial infarction (MI) rely on blood-based cardiac biomarker analysis by centralized instruments, often delaying timely clinical decisions. We present a microneedle-based capacitive biosensor (MiCaP) for in situ minima ...

AMER CHEMICAL SOC2025

ERGODICITY OF 2D SINGULAR STOCHASTIC NAVIER–STOKES EQUATIONS

Martin Hairer

We consider the 2D stochastic Navier–Stokes equations driven by noise that have the regularity of space-time white noise but don’t exactly coincide with it. We show that, provided that the intensity of the noise is sufficiently weak at high frequencies, th ...

2025

The Utah FORGE 2022 hydraulic stimulations: tensile hydraulic fractures or/and fluid-induced dilatant shear ruptures?

Sylvain Pierre Brisson, Brice Tanguy Alphonse Lecampion

We investigate two hydraulic stimulation stages performed in April 2022 at the Utah FORGE enhanced geothermal system test site using analytical solutions and numerical modeling of fluid-induced tensile and shear rupture problems. These stimulation stages d ...

2025

Collisional effects on positive and negative triangularity through local and global temperature gradient-driven and flux-driven gyrokinetic simulations

Laurent Villard, Stephan Brunner, Moahan Murugappan, Giovanni Di Giannatale, Alessandro Balestri

In this work, we explore the effects of collisions on turbulent transport, focusing on two different TCV magnetic equilibria featuring positive and negative triangularity. The investigation is conducted using gyrokinetic modeling. Both gradient-driven and ...

2025

Noise-induced transitions past the onset of a steady symmetry-breaking bifurcation: The case of the sudden expansion

François Gallaire, Edouard Boujo, Yves-Marie François Ducimetière

We consider fluid flows, governed by the Navier-Stokes equations, subject to a steady symmetry-breaking bifurcation and forced by a weak noise acting on a slow timescale. By generalizing the multiple-scale weakly nonlinear expansion technique employed in t ...

2024

Novel theory and potential applications of central diastolic pressure decay time constant

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas, Sokratis Anagnostopoulos

Central aortic diastolic pressure decay time constant ( ) is according to the two-element Windkessel model equal to the product of total peripheral resistance (R) times total arterial compliance (C ). As such, it is related to arterial stiffness, which has ...

2024

The role of computational methods in cardiovascular medicine: a narrative review

Alfio Quarteroni, Luca Dede', Christian Vergara, Stefano Pagani

Background and Objective: Computational models of the cardiovascular system allow for a detailed and quantitative investigation of both physiological and pathological conditions, thanks to their ability to combine clinical-possibly patient-specific-data wi ...

Ame Publishing Company2024

Anomalous dissipation and other non-smooth phenomena in fluids

Massimo Sorella

The thesis is dedicated to the study of two main partial differential equations (PDEs) in fluid dynamics: the Navier-Stokes equations, which describe the motion of incompressible fluids, and the transport equation with divergence-free velocity fields, whic ...

EPFL2024

Quantitative convergence rates for scaling limit of SPDEs with transport noise

Lucio Galeati

We consider on the torus the scaling limit of stochastic 2D (inviscid) fluid dynamics equations with transport noise to deterministic viscous equations. Quantitative estimates on the convergence rates are provided by combining analytic and probabilistic ar ...

Academic Press Inc Elsevier Science2024

Whole-heart electromechanical simulations using Latent Neural Ordinary Differential Equations

Alfio Quarteroni, Luca Dede', Francesco Regazzoni

Cardiac digital twins provide a physics and physiology informed framework to deliver personalized medicine. However, high-fidelity multi-scale cardiac models remain a barrier to adoption due to their extensive computational costs. Artificial Intelligence-b ...

Nature Portfolio2024

Apparatus for non-invasively computing cardio-vasculature parameters using morphology of uncalibrated pressure wave signal

Nikolaos Stergiopoulos, Vasiliki Bikia, Georgios Rovas

Systems and apparatus are provided for using a non-invasively monitored uncalibrated pressure signal from a patient to compute cardiac output and other cardio-vascular parameters, thereby providing safe, effective, reliable and low cost monitoring of patie ...

2024

Adaptive Finite Elements with Large Aspect Ratio. Application to Aluminium Electrolysis

Paride Passelli

The goal of this work is to use anisotropic adaptive finite elements for the numerical simulation of aluminium electrolysis. The anisotropic adaptive criteria are based on a posteriori error estimates derived for simplified problems. First, we consider an ...

EPFL2024

Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period

Silvestro Micera

The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive me ...

Aip Publishing2024

Mechanisms and functions of protein S-acylation

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Francisco De Magalhães Sarmento Ribeiro De Mesquita

Over the past two decades, protein S-acylation (often referred to as S-palmitoylation) has emerged as an important regulator of vital signalling pathways. S-Acylation is a reversible post-translational modification that involves the attachment of a fatty a ...

Nature Portfolio2024

A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional patient data

Alfio Quarteroni

Stroke, a major global health concern often rooted in cardiac dynamics, demands precise risk evaluation for targeted intervention. Current risk models, like the CHA 2 DS 2 -VASc \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepa ...

Nature Portfolio2024

Nonlinear simulation of plasma turbulence using a gyrokinetic moment-based approach

Antoine Cyril David Hoffmann

Plasma turbulence plays a fundamental role in determining the performances of magnetic confinement fusion devices, such as tokamaks. Advances in computer science, combined with the development of efficient physical models, have significantly improved our u ...

EPFL2024

Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve

Gilles Fourestey

BackgroundImpaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve (ON), including Alzheimer's and Parkinson's disease, as well as frontotemporal dementia ...

BMC2024