Influence of atrial substrate on local capture induced by rapid pacing of atrial fibrillation

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ECG-Based Indices to Characterize Persistent Atrial Fibrillation Before and During Stepwise Catheter Ablation

Jean-Marc Vesin, Etienne Pruvot, Adrian Luca

Background: Consistently successful patient outcomes following catheter ablation (CA) for treatment of persistent atrial fibrillation (pers-AF) remain elusive. We propose an electrocardiogram (ECG) analysis designed to (1) refine selection of patients most ...

2021

Five-year follow-up of intracoronary autologous cell therapy in acute myocardial infarction: the REGENERATE-AMI trial

John Martin Kolinski, Didier Locca

Aims The long-term outcomes of the intracoronary delivery of autologous bone marrow-derived cells (BMCs) after acute myocardial infarction are not well established. Following the promising 1 year results of the REGENERATE-AMI trial (despite it not achievin ...

WILEY PERIODICALS, INC2022

Association of Heart Rate Variability With Silent Brain Infarcts in Patients With Atrial Fibrillation

Jean-Marc Vesin, Vincent Schlageter

Purpose: Silent brain infarcts (SBI) are frequently detected in patients with atrial fibrillation (AF), but it is unknown whether SBI are linked to autonomic dysfunction. We aimed to explore the association of autonomic dysfunction with SBI in AF patients. ...

FRONTIERS MEDIA SA2021

Fault Detection and Diagnosis with Imbalanced and Noisy Data: A Hybrid Framework for Rotating Machinery

Amin Kaboli

Fault diagnosis plays an essential role in reducing the maintenance costs of rotating machinery manufacturing systems. In many real applications of fault detection and diagnosis, data tend to be imbalanced, meaning that the number of samples for some fault ...

MDPI2022

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Alfio Quarteroni, Andrea Manzoni

In the context of cardiac electrophysiology, we propose a novel computational approach to highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to reliably numerically predict its induction and sustainment. A key role is pla ...

FRONTIERS MEDIA SA2021

Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure

Yi Zhang, Annina Stuber

BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...

LIPPINCOTT WILLIAMS & WILKINS2022

Single-Trace Clustering Power Analysis of the Point-Swapping Procedure in the Three Point Ladder of Cortex-M4 SIKE

Aymeric Genet, Novak Kaluderovic

In this paper, the recommended implementation of the post-quantum key exchange SIKE for Cortex-M4 is attacked through power analysis with a single trace by clustering with the k-means algorithm the power samples of all the invocations of the elliptic curve ...

Springer, Cham2022

Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation

Jean-Marc Vesin, Etienne Pruvot, Andréa Buttu, Adrian Luca

Background: The role of dominant frequency (DF) in tracking the efficiency of a stepwise catheter ablation (step-CA) in persistent atrial fibrillation (peAF) remains poorly studied. We hypothesized that the DF time-course during step-CA displays divergent ...

2021

A Variable Stiffness Magnetic Catheter Made of a Conductive Phase-Change Polymer for Minimally Invasive Surgery

Dario Floreano, Jun Shintake, Yegor Piskarev

Variable stiffness (VS) is an important feature that significantly enhances the dexterity of magnetic catheters used in minimally invasive surgeries. Existing magnetic catheters with VS consist of sensors, heaters, and tubular structures filled with low me ...

2022

Implantable Fiber Bragg Grating Sensor for Continuous Heart Activity Monitoring: Ex-Vivo and In-Vivo Validation

Silvestro Micera

Continuous and reliable cardiac function monitoring could improve medication adherence in patients at risk of heart failure. This work presents an innovative implantable Fiber Bragg Grating-based soft sensor designed to sense mechanical cardiac activity. T ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Graph Neural Networks With Lifting-Based Adaptive Graph Wavelets

Pascal Frossard

Spectral-based graph neural networks (SGNNs) have been attracting increasing attention in graph representation learning. However, existing SGNNs are limited in implementing graph filters with rigid transforms and cannot adapt to signals residing on graphs ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Computational methods for live heart imaging with speed-constrained microscopes

Olivia Mariani

Imaging methods to capture the beating and developing heart inside embryonic animal models such as the zebrafish are a key component for the study of fundamental biological processes such as cardiac birth defects or tissue regeneration. However, live heart ...

EPFL2021