Publications associées à Rational design of platinum(IV) compounds to overcome glutathione-S-transferase mediated drug resistance

Publications associées (8)

Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes

A series of Cu(diimine)(X-sal)(NO3) complexes, where the diimine is either 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) and X-sal is a monoanionic halogenated salicylaldehyde (X = Cl, Br, I, or H), have been synthesized and characterized by elementa ...

AMER CHEMICAL SOC2020

Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

Paul Joseph Dyson, Christian Hartinger, Angela Casini, Michael Groessl

Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their interactions with biomolecules and potential targets on a molecular level. The exact modes-of-action of ...

Royal Society of Chemistry2013

Activation of Nitrous Oxide by Dinuclear Ruthenium Complexes

Rosario Scopelliti, Kay Severin, Euro Solari, Alexander Tskhovrebov

The dinuclear Ru(II) complexes (arene)Ru(μ-Cl)3RuCl(C2H4)(PCy3) (arene = p-cymene or 1,3,5-C6H3iPr3) react with N2O under mild conditions to give OPCy3 and the trinuclear complexes (arene)Ru(μ-Cl)3Ru(μ-Cl)3Ru(arene). The N-heterocyclic carbene complex (p-c ...

American Chemical Society2012

Ruthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties

Paul Joseph Dyson, Angela Casini, Fabio Edafe, Dennis Snelders

The synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl-2(L) (L - oligocationic phosphine), are reported. The complexes are ...

2011

Anticancer Therapeutics That Target Selenoenzymes: Synthesis, Characterization, in vitro Cytotoxicity, and Thioredoxin Reductase Inhibition of a Series of Gold(I) Complexes Containing Hydrophilic Phosphine Ligands

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava

Gold(I) complexes bearing water-sol. phosphine ligands, including 1,3,5-triaza-7-phosphaadamantane (PTA), 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA), and sodium triphenylphosphine trisulfonate (TPPTS), in combination with thionate liga ...

Wiley-Blackwell2010

High Resolution Mass Spectrometry for Studying the Interactions of Cisplatin with Oligonucleotides

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger, Hisham Ben Hamidane

Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been used to probe the interaction of the anticancer drug cisplatin with oligonucleotides. The binding kinetics, the nature of the adducts formed, and the location of the binding s ...

2008

The role of cisplatin and NAMI-A plasma-protein interactions in relation to combination therapy

Paul Joseph Dyson

The aim of the study is to evaluate the differences of protein binding of NAMI-A, a new ruthenium drug endowed with selective antimetastatic properties, and of cisplatin and to ascertain the possibility to use two drugs based on heavy metals in combination ...

2006

In vitro and in vivo evaluation of ruthenium(II)-arene PTA complexes

Paul Joseph Dyson, Gabor Laurenczy, Claudine Scolaro

The antitumor activity of the organometallic ruthenium(II)-arene complexes, RuCl2(eta(6)-arene)(PTA), (arene = p-cymene, toluene, benzene, benzo-15-crown-5, 1-ethylbenzene-2,3-dimethylimidazolium tetrafluoroborate, ethyl benzoate, hexamethylbenzene; PTA = ...

2005