Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification

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The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...

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The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TE ...

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BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology. Several studies have drawn connections between altered retrotransposon expression and ALS. C ...

Kruppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB domain and a C-terminal array of DNA-binding zinc fingers, they participate, toge ...

Background: The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occu ...

Transposable elements (TEs) are DNA sequences able to change position in the genome, and represent more than 40% of mammalian genetic material. TEs can have positive or detrimental effects on the host, being both important motors of evolution and genomic t ...

Sequencing the genome of Candida albicans as it evolves in a patient reveals the genetic changes that allow the yeast to adapt to its environment. ...

Heartbeat on repeat: noncanonical KZFP and its transposable element targets shape cardiac cell specification

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PSGL-1 is an evolutionarily conserved antiviral restriction factor

Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

Preparation of Single-Somite Explants from Zebrafish Embryos

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

The Metal Catalyst Influences the Kinetics and Mechanisms of MS2 Inactivation in Fenton-like Systems

Virosaurus A Reference to Explore and Capture Virus Genetic Diversity

The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

KRAB zinc finger proteins

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Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

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