Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

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Publications associées (29)

Concise Reviews: In Vitro-Produced Pancreas Organogenesis Models in Three Dimensions: Self-Organization From Few Stem Cells or Progenitors

Anne Grapin-Botton, Chiara Greggio, Filippo De Franceschi

Three-dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of ce ...

Wiley-Blackwell2015

In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors

Anne Grapin-Botton, Chiara Greggio, Filippo De Franceschi

The pancreas is an essential organ that regulates glucose homeostasis and secretes digestive enzymes. Research on pancreas embryogenesis has led to the development of protocols to produce pancreatic cells from stem cells. The whole embryonic organ can be c ...

Journal Of Visualized Experiments2014

Assessing the role of Hes1 and identification of target genes in human and murine T-ALL

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The Notch signalling pathway is an ancient cell signalling mechanism that enables short-range communications between cells and controls a broad spectrum of cell fates and developmental processes. In the haematopoietic system Notch signalling has been linke ...

EPFL2014

MicroRNA 21 is a novel oncogene in Notch1-driven acute lymphoblastic T cell leukemia

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Notch signaling is a conserved cell-to-cell communication pathway essential in the development and maintenance of various tissues. Upon ligand binding, Notch receptors on the cell surface are proteolytically cleaved, generating the intracellular domain of ...

EPFL2014

Modeling Tumor Microenvironments In Vitro

Melody Swartz, Mingming Wu

Tumor progression depends critically upon the interactions between the tumor cells and their microenvironment. The tumor microenvironment is heterogeneous and dynamic; it consists of extracellular matrix, stromal cells, immune cells, progenitor cells, and ...

Asme2014

Artificial three-dimensional niches deconstruct pancreas development in vitro

Matthias Lütolf, Anne Grapin-Botton, Chiara Greggio, Adrian Ranga, Samy Gobaa, Filippo De Franceschi

In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion and subsequent differentiation into insulin-producing beta cells would be extremely valuable. Here we establish three-dimensional culture conditions in Matrigel ...

Company Of Biologists Ltd2013

Transcription factor ROR alpha is critical for nuocyte development

Freddy Radtke, Ute Koch

Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously ...

2012

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

Anne Grapin-Botton, Mathieu Gouzi, Cédric Cortijo

Planar cell polarity (PCP) refers to the collective orientation of cells within the epithelial plane. We show that progenitor cells forming the ducts of the embryonic pancreas express PCP proteins and exhibit an active PCP pathway. Planar polarity proteins ...

Cell Press2012

Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

Melissa Maggioni

The thymus is a primary lymphoid organ where bone marrow derived T-cell progenitors come in contact with a unique microenvironment able to sustain their maturation into functional T-cells. This fundamental immunological function of the thymus is supported ...

EPFL2012

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