In Vitro Human Liver Model of Nonalcoholic Steatohepatitis by Coculturing Hepatocytes, Endothelial Cells, and Kupffer Cells

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Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes is critical to coordinate complex comp ...

In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuations of ...

The mammalian liver is a central hub for systemic metabolic homeostasis. Liver tissue is spatially structured, with hepatocytes operating in repeating lobules, and sub-lobule zones performing distinct functions. The liver is also subject to extensive tempo ...

BSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic live ...

Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take a lon ...

This work presents the study of suspended Y-cut Lithium Niobate shear bulk acoustic resonators for wide band filter applications in the frequency range of 3.5-4.5GHz. The resonators consist of a Lithium Niobate film with Aluminum top interdigitated electro ...

This work deals with a control strategy to regulate homogeneous reaction systems in reactors equipped with a cooling jacket. The reaction system is expressed in terms of vessel extents and viewed as a single-input (the inlet coolant temperature), two-outpu ...

Background: The gut microbiome and iron status are known to play a role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear. Results: Here, we applied an integrative systems medicine approa ...

In this work, we propose an analytical model for the intrinsic transcapacitances in ultra-thin gate-all-around junctionless nanowire field effect transistors in the presence of confined energy states of electrons. The validity of the developed model is con ...

Advances in our understanding of the biology of stem cells and their niches have provided the necessary foundation to create in vitro complex self-organizing three-dimensional (3D) structures called organoids. While organoids represent a highly promising n ...

Over the past two decades, the thermo-hydro-mechanical behavior of earth-contact structures such as piles, walls, slabs, and tunnels, which simultaneously provide structural support and energy supply, has been studied through various field experiments and ...

Gene expression in eukaryotes is a complex multi-step process. It starts in the nucleus with transcription, the synthesis of a mRNA copy from a DNA template. While in the nucleus, the RNA transcript is subject to multiple co- and post-transcriptional modif ...

The synthesis of high-performance gas-sieving zeolitic film is challenging because it involves seeded secondary growth which is complex and difficult to reproduce. Additionally, expensive asymmetric inorganic porous supports are often needed for calcinatio ...

As both a consumer and producer of glucose, the kidney plays a significant role in glucose homeostasis. Measuring renal gluconeogenesis requires invasive techniques, and less invasive methods would allow renal gluconeogenesis to be measured more routinely. ...

A programmable patient-customized epileptic seizure detector is proposed in this paper to enable neurologists and patients to have constructive interactions with the implantable medical device. The programmability feature is enabled by designing a low-powe ...

Background: Although digital mobility outcomes (DMOs) can be readily calculated from real-world data collected with wearable devices and ad-hoc algorithms, technical validation is still required. The aim of this paper is to comparatively assess and validat ...

Sirtuin 3 (SIRT3) is a protein deacetylase regulating beta-cell function through inhibiting oxidative stress in obese and diabetic mice, but the detailed mechanism and potential effect of beta-cell-specific SIRT3 on metabolic homeostasis, and its potential ...

Current procedures for the rapid inspection of buildings and infrastructure are subjective, time-consuming, and cumbersome to document, necessitating new technologies to automate the process and eliminate these shortcomings. Fortunately, recent development ...

In Vitro Human Liver Model of Nonalcoholic Steatohepatitis by Coculturing Hepatocytes, Endothelial Cells, and Kupffer Cells

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Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology

Comprehensive analysis of the circadian nuclear and cytoplasmic transcriptome in mouse liver

Space-time logic of liver gene expression at sub-lobular scale

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

High Resolution Light-Based 3D Printing Of Cell-Laden Bio Constructs

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease

Toward Band n78 Shear Bulk Acoustic Resonators Using Crystalline Y-Cut Lithium Niobate Films With Spurious Suppression

Output regulation via trajectory tracking for chemical reactors with jacket dynamics

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

Transcapacitances Modeling in ultra-thin gate-all-around junctionless nanowire FETs, including 2D quantum confinement

Defined matrices for epithelial organoid culture and disease modelling

Thermo-hydro-mechanical behavior of energy barrettes: Field experiments and numerical simulations

Circadian dynamics of RNA localisation in the mammalian liver

Hydrogen-sieving zeolitic films by coating zeolite nanosheets on porous polymeric support

Assessment of Aspartate and Bicarbonate Produced From Hyperpolarized [1-13C]Pyruvate as Markers of Renal Gluconeogenesis

Programmable Seizure Detector Using a 32-bit RISC Processor for Implantable Medical Devices

Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Damage-augmented digital twins towards the automated inspection of buildings