Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing

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Neurons in the human amygdala and hippocampus are classically thought to encode a person’s identity invariant to visual features. However, it remains largely unknown how visual information from higher visual cortical areas is translated into such a semanti ...

Neuroscience has evolved by framing numerous neuropsychiatric conditions as network diseases. Alterations within neurotransmitter (NT) systems are central to the development of these diseases. Recently, normative data on whole-brain NT fingerprints derived ...

Neural organoids and spheroids are three-dimensional (3D) in vitro brain models that mimic key aspects of human brain cellular composition, organization, and function. These models have become essential for studying brain development and neurological disor ...

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

Adverse experiences during infancy and adolescence have an important and enduring effect on the brain and are predisposing factors for mental disorders, particularly major depression. This impact is particularly notable in regions with protracted developme ...

Information is transmitted between brain regions through the release of neurotransmitters from long-range projecting axons. Understanding how the activity of such long-range connections contributes to behavior requires efficient methods for reversibly mani ...

The decline of motor ability is a hallmark feature of aging and is accompanied by degeneration of motor synaptic terminals. Consistent with this, Drosophila motor synapses undergo characteristic age -dependent structural fragmentation co -incident with dim ...

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Background: Sleep deprivation causes hippocampal injury, manifesting as neuronal damage and learning-memory impairment. These negative effects may be associated with disturbance of hippocampal glutamate and water homeostasis, which induces excessive neuron ...

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

The synaptic and neuronal circuit mechanisms underlying reward-based learning remain to be fully determined. In the mammalian brain, dopamine release in nucleus accumbens is thought to contribute importantly to reward signals for learning and promoting syn ...

Animals, including humans, exhibit a remarkable variety of complex behaviours. How the nervous system controls all these behaviours ranging from simple, stereotyped movements to flexible, adaptive actions is a central questions of neuroscience. One of the ...

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which functions as an ion channel and a phospholipid scramblase. Despite the availability of several TMEM16F cryogenic electron microscopy (cryo-EM) structures, the mechanism of activation ...

Recent developments in experimental techniques have enabled simultaneous recordings from thousands of neurons, enabling the study of functional cell assemblies. However, determining the patterns of synaptic connectivity giving rise to these assemblies rema ...

The outstanding information processing capacity of the brain relies on numerous molecular mechanisms. It is an extremely energy-expensive function, which involves specialization and collaboration of different cell types. A common framework to study the com ...

Developing spinal circuits generate patterned motor outputs while many neurons with high membrane resistances are still maturing. In the spinal cord of hatchling frog tadpoles of unknown sex, we found that the firing reliability in swimming of inhibitory i ...

Spinal cord injury (SCI) interrupts axonal connections between the brain and the spinal cord, and is characterized by a spectrum of sensorimotor and autonomic impairments. While spontaneous recovery is limited, recent studies have shown that functional imp ...

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

An important function of the brain is to interpret incoming sensory information from the outside world to guide adaptive behavior. Understanding how and where sensory information is transformed into motor commands in a context- and learning-dependent manne ...

Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing

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Feature-based encoding of face identity by single neurons in the human amygdala and hippocampus

Neurotransmitter-informed connectivity maps and their application for outcome inference after stroke

Soft microelectrode arrays for 3D in vitro brain models

Subcortical correlates of consciousness with human single neuron recordings

Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

Trio preserves motor synapses and prolongs motor ability during aging

White adipose tissue distribution and amount are associated with increased white matter connectivity

Five percent CO2 inhalation alleviates hippocampal glutamate and water homeostasis disturbance, neuronal damage, and learning-memory impairment in sleep-deprived rats

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Dopamine dynamics in nucleus accumbens across reward-based learning of goal-directed whisker-to-lick sensorimotor transformations in mice

Uncovering interactions between Descending Neurons as a functional principle of behavioural control

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

Structural heterogeneity of the ion and lipid channel TMEM16F

Cortical cell assemblies and their underlying connectivity: an in silico study

Molecular reconstruction and simulation of the Neuron-Glia-Vasculature system

Mechanisms Underlying the Recruitment of Inhibitory Interneurons in Fictive Swimming in Developing Xenopus laevis Tadpoles

Targeted regeneration of spinal cord neurons across a complete injury restores walking

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Neuronal correlates of goal-directed sensorimotor transformation in sensory, motor and higher-order cortical areas