Publications associées à Hyperpolarized Magnetic Resonance as a Sensitive Detector of Metabolic Function

Development and clinical validation of computational imaging biomarkers for neurodegenerative diseases

Neurodegenerative and neuroinflammatory disorders often involve complex pathophysiological mechanisms that are â to this date â only partially understood. A more comprehensive understanding of those microstructural processes and their characterization ...

EPFL2024

Streamline RimNet: Tools for Automatic Classification of Paramagnetic Rim Lesions in MRI of Multiple Sclerosis

Meritxell Bach Cuadra, Cristina Granziera, Francesco La Rosa, Maxence Charles F Wynen

This site provides two software tools related to "RimNet: A deep 3D multimodal MRI architecture for paramagnetic rim lesion assessment in multiple sclerosis" by Barquero et al. NeuroImage: Clinical (2020). People using in part or f ...

Zenodo2023

A Modular Workflow for Model Building, Analysis, and Parameter Estimation in Systems Biology and Neuroscience

Daniel Keller, Andrii Stepaniuk

Neuroscience incorporates knowledge from a range of scales, from single molecules to brain wide neural networks. Modeling is a valuable tool in understanding processes at a single scale or the interactions between two adjacent scales and researchers use a ...

HUMANA PRESS INC2022

ICRF modelling in 2D and 3D magnetic configurations using a hot plasma model

Wilfred Anthony Cooper, Jonathan Graves, Mike Machielsen

The generation of energetic trapped ions is important for experiments investigating their confinement in 3D magnetic fields, for plasma heating, for studies into unwanted drive of instabilities, and improved transport regimes. An effective way to generate ...

2021

Development of novel tools for imaging of metabolic fluxes in vivo

Tamara Maric

Bioluminescent imaging is a powerful technique that enables imaging in living organisms with high sensitivity, low background signal, low cost and without the need for radioactivity. The emitted photons are produced in the oxidation reaction of luciferin c ...

EPFL2020

Modeling chloride transport using travel time distributions at Plynlimon, Wales

Andrea Rinaldo, Gianluca Botter, Paolo Benettin

Here we present a theoretical interpretation of high-frequency, high-quality tracer time series from the Hafren catchment at Plynlimon in mid-Wales. We make use of the formulation of transport by travel time distributions to model chloride transport origin ...

Amer Geophysical Union2015

In-situ photopolymerization and monitoring device for controlled shaping of tissue fillers, replacements or implants

Dominique Pioletti, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Photopolymerization is a common tool to harden materials initially in a liquid state. A surgeon can directly trigger the solidification of a dental implant or a bone or tissue filler simply by illumination. Traditionally, photopolymerization has been used ...

Spie-Int Soc Optical Engineering2015

Photopolymerization device for minimally invasive implants: application to nucleus pulposus replacement

Dominique Pioletti, Pierre-Etienne Bourban, Andreas Schmocker, Azadeh Khoushabi, Christophe Moser

Photopolymerization is a common tool to harden materials initially in a liquid state. A surgeon can directly trigger the solidification of a dental implant or a bone or tissue filler. Traditionally, photopolymerization has been used mainly in dentistry. Ov ...

Springer2015

Design of computational retrobiosynthesis tools for the design of de novo synthetic pathways

Vassily Hatzimanikatis, Noushin Hadadi

Designing putative metabolic pathways is of great interest in synthetic biology. Retrobiosynthesis is a discipline that involves the design, evaluation, and optimization of de novo biosynthetic pathways for the production of high-value compounds and drugs ...

Elsevier Sci Ltd2015

Molecular Orbital Gates for Plasmon Excitation

Klaus Kern, Uta Schlickum, Alexander Kabakchiev, Theresa Lutz, Christian Alexander Stephan Dette, Christoph Grosse

Future combinations of plasmonics with nanometer-size electronic circuits require strategies to control the electrical excitation of plasmons at the length scale of individual molecules. A unique tool to study the electrical plasmon excitation with ultimat ...

Amer Chemical Soc2013

Generation and characterization of a Notch1 signaling-specific reporter mouse line

Yann Barrandon, Stéphanie Claudinot, Freddy Radtke, Rajwinder Lehal, Luca Pellegrinet

Signaling through the Notch1 receptor is essential for the control of numerous developmental processes during embryonic life as well as in adult tissue homeostasis and disease. Since the outcome of Notch1 signaling is highly context-dependent, and its prec ...

Wiley-Blackwell2012

Mathematical Modeling of Brain Energy Metabolism, Measured with PET and MRS in Rodents

Bernard Lanz

Positron emission tomography (PET) and nuclear magnetic resonance spectroscopy (MRS) are two biomedical measurement techniques developed in the end of the XXth century, which drastically improved the amount of accessible information available in vivo. PET ...

EPFL2012

Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

Arnaud Comment

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo with the goal of improved diagnosis and perhaps therapy. Because of the complexity of biochemical pathways, tracer methods are required for detecting specific enzyme ...

2011

NC tool path evaluator and generator for high speed milling

Sandeep Dhanik

Milling is a most common type of material removal process by rotating tools to create a variety of features on a part. The material is removed in a controlled way by sweeping a rotating cylindrical tool along the specific trajectory known as milling tool p ...

EPFL2009

SUNtool - A new modelling paradigm for simulating and optimising urban sustainability

Nicolas Morel, Jessen Page, Darren Robinson

This paper describes the development and application of a new unique tool to support designers to optimise the sustainability of urban neighbourhoods (SUNtool). In this the paper introduces (i) the software architecture, (ii) the integrated solver and rela ...

2007

Site selective functionalizations of fluorinated heterocycles

Heterocyclic chem. continues to be in the focus of life science-oriented research. Fluorine, a unique tool for finetuning biol. properties, offers an extra bonus in this context. The lecture features three pertinent issues. First, proven and novel routes t ...

2006

Improved MRSI with Field Inhomogeneity Compensation

Michaël Unser, Mathews Jacob, Dimitri Nestor Alice Van De Ville, Ildar Khalidov

Magnetic resonance spectroscopy imaging (MRSI) is a promising and developing tool in medical imaging. Because of various difficulties imposed by the imperfections of the scanner and the reconstruction algorithms, its applicability in clinical practice is r ...

SPIE2006