Noninvasive deep brain stimulation to modulate human behavior by means of transcranial temporal interference electrical stimulation

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Over the past decade, research has shown that the primary motor cortex (M1), the brain's main output for movement, also responds to rewards. These reward signals may shape motor output in its final stages, influencing movement invigoration and motor learni ...

Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

The prefrontal cortex (PFC) is a brain region involved in higher-order cognitive processes such as attention, emotional regulation, and social behavior. However, the delineation of distinct subdivisions within the mouse PFC and their contributions to the b ...

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Human motor skill acquisition is improved by performance feedback, and coupling such feedback with extrinsic reward (such as money) can enhance skill learning. However, the neurophysiology underlying such behavioral effect is unclear. To bridge this gap, w ...

The lumbosacral spinal cord contains neural circuits crucial for locomotion, organized into rostrocaudal levels with distinct somatosensory and motor neuron pools that project to and from the muscles of the lower limbs. However, the specific spinal levels ...

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

Brain organoids enable the mechanistic study of human brain development and provide opportunities to explore self-organization in unconstrained developmental systems1, 2–3. Here we establish long-term, live light-sheet microscopy on unguided brain organoid ...

Motivation is a multifaceted phenomenon that we explore within the framework of decision-making. Through this cognitive process, actions are directed towards specific goals by performing a trade-off between the cost and benefit of an action. The dorsomedia ...

As the demand for high channel counts and high-resolution recordings of neural activity continues to grow, the increased power and data rate generated impose hard constraints on the telemetry capabilities of wireless implantable neural interfaces. To addre ...

Transformer models such as GPT generate human-like language and are predictive of human brain responses to language. Here, using functional-MRI-measured brain responses to 1,000 diverse sentences, we first show that a GPT-based encoding model can predict t ...

Our sense of agency, the subjective experience of controlling our actions, is a crucial component of self-awareness and motor control. It is thought to originate from the comparison between intentions and actions across broad cortical networks. However, th ...

Understanding behavior requires datasets that capture humans while carrying out complex tasks. The kitchen is an excellent environment for assessing human motor and cognitive function, as many complex actions are naturally exhibited in kitchens from choppi ...

Objective. Selective neuromodulation of deep brain regions has for a long time only been possible through invasive approaches, because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques. Approach. An appr ...

A novel fast 3D-31P-B+1 mapping method called the frequency-selective Double-AngleMethod (fDAM) has been developed. This method integrates a 3D weighted stack of spiral gradient echo acquisitions with a frequency-selective pulse to efficiently map B+1 fiel ...

The growing global obesity issue emphasizes the importance of understanding its health implications. Previous research has identified consistent alterations in gray matter (GM) volume in connection with obesity. Given the various implications of distinct f ...

The study of brain disorders has long been central to both neurology and psychiatry, with these two disciplines evolving as distinct yet deeply interconnected fields. In fact, these specialties often share overlapping symptoms, neural pathways, and treatme ...

Implanted medical devices (IMDs) have been widely developed to support the monitoring and recording of biological data inside the body or brain. Wirelessly powered IMDs, a subset of implantable electronics, have been proposed to eliminate the limitations r ...

Restoring the ability to walk is a priority for individuals with neurological disorders or neurotraumatic injuries, given its significant impact on independence and quality of life. Multimodal closed-loop strategies that integrate robotic assistance and ne ...

The temporal variability of the thalamus in functional networks may provide valuable insights into the pathophysiology of schizophrenia. To address the complexity of the role of the thalamic nuclei in psychosis, we introduced micro-co-activation patterns ( ...

Noninvasive deep brain stimulation to modulate human behavior by means of transcranial temporal interference electrical stimulation

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Reward signals in the motor cortex: from biology to neurotechnology

Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Functional-based parcellation of the mouse prefrontal cortex for network perturbation analysis

White adipose tissue distribution and amount are associated with increased white matter connectivity

Effect of Extrinsic Reward on Motor Plasticity during Skill Learning

Towards personalized mapping through lumbosacral spinal cord task fMRI

Subcortical correlates of consciousness with human single neuron recordings

Morphodynamics of human early brain organoid development

Neurobiological and metabolic basis of motivation and effort-based decision-making - A human 1H-MRS, fMRI and machine learning study

A Reconfigurable High-Dynamic Range ∆Σ Front-End with Event-Based Decimation for Bandwidth-Efficient Implantable Neural Interfaces

Driving and suppressing the human language network using large language models

Pre-movement sensorimotor oscillations shape the sense of agency by gating cortical connectivity

EPFL-Smart-Kitchen-30 Collected data

Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions

Fast Quantification of Creatine Kinase Activity by Phosphorus Magnetic Resonance Fingerprinting

The interplay between white adipose tissue, adipokines, and structural gray matter changes

The Interdisciplinary Synergy Between Neurology and Psychiatry: Advancing Brain Health

Integrated Wireless Power, Data Communication, and Thermal Sensing System for Autonomous Multisite Brain Implants

Multimodal closed-loop strategies for gait recovery after spinal cord injury and stroke via the integration of robotics and neuromodulation

Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs)