Flow diversion treatment: intra-aneurismal blood flow velocity and WSS reduction are parameters to predict aneurysm thrombosis

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Pulsatile Flow-Induced Fatigue-Resistant Photopolymerizable Hydrogels for the Treatment of Intracranial Aneurysms

Dominique Pioletti, Christophe Moser, Mahmut Selman Sakar, Andreas Schmocker, Lucio Feo Pancaldi-Giubbini, Oriane Poupart

An alternative intracranial aneurysm embolic agent is emerging in the form of hydrogels due to their ability to be injected in liquid phase and solidify in situ. Hydrogels have the ability to fill an aneurysm sac more completely compared to solid implants ...

2021

In situ photopolymerizable hydrogels for intracranial aneurysms treatment

Oriane Poupart

Intracranial aneurysm is a cerebrovascular disease characterized by an artery dilation in the brain. An aneurysm is prone to rupture, which causes a life-threatening subarachnoid hemorrhage. The major drawbacks of the current treatments, open surgical clip ...

EPFL2021

Transient Neurovascular Interface for Minimally Invasive Neural Recording and Stimulation

Diego Ghezzi, Philippe Reymond, Laura Ferlauto, Adele Fanelli, Elodie Geneviève Zollinger

Neural interfaces are used to mitigate the burden of traumatic injuries, neurodegenerative diseases, and mental disorders. However, the transient or permanent placement of an interface in close contact with the neural tissue requires invasive surgery, pote ...

Wiley2021

Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT

Goran Lovric

In pulmonary arterial hypertension, plexiform lesions are associated with severe arterial obstruction and right ventricular failure. Exploring their structure and position is crucial for understanding the interplay between hemodynamics and vascular remodel ...

AMER PHYSIOLOGICAL SOC2021

Deep Learning Building on Prior Ischemic Core Segmentation Improves Prediction of Infarction After Stroke

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti, Elisabeth Anne Dirren

Introduction: Imaging studies are used to guide patient selection for acute stroke treatment. Perfusion CT (pCT) is widely used to identify the acute ischemic core and penumbra, but the prediction of the final infarct remains challenging. With the advent o ...

LIPPINCOTT WILLIAMS & WILKINS2021

Three-dimensional fluid-driven stable frictional ruptures

Brice Tanguy Alphonse Lecampion, Alexis Alejandro Sáez Uribe

We investigate the quasi-static growth of a fluid-driven frictional shear crack that propagates in mixed mode (II+III) on a planar fault interface that separates two identical half-spaces of a three-dimensional solid. The fault interface is characterized b ...

2022

Follicular regulatory helper T cells control the response of regulatory B cells to a high-cholesterol diet

Nikolaos Stergiopoulos

Aims B cell functions in the process of atherogenesis have been investigated but several aspects remain to be clarified. ...

OXFORD UNIV PRESS2021

Reduction techniques for PDEs built upon Reduced Basis and Domain Decomposition Methods with applications to hemodynamics

Luca Pegolotti

This thesis focuses on the development and validation of a reduced order technique for cardiovascular simulations. The method is based on the combined use of the Reduced Basis method and a Domain Decomposition approach and can be seen as a particular imple ...

EPFL2021

Automated flow control of a multi-lane swimming chamber for small fishes indicates species-specific sensitivity to experimental protocols

Paulin Olivier Raison

In fishes, swimming performance is considered an important metric to measure fitness, dispersal and migratory abilities. The swimming performance of individual larval fishes is often integrated into models to make inferences on how environmental parameters ...

2021

Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis

Lydia Aslanidou

Atherosclerosis is a lipid driven chronic inflammatory disease that is characterized by the formation of plaques at predilection sites. These predilection sites (side branches, curved segments, and bifurcations) have often been associated with disturbed sh ...

ELSEVIER SCI LTD2021

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases

Jian Wang, Friedhelm Christoph Hummel

The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially p ...

2021

Shape optimization of segmental porous baffles for enhanced thermo-hydraulic performance of shell-and-tube heat exchanger

Hossein Pourrahmani

This study presents the development and evaluation of a novel shell-and-tube heat exchanger (STHX) design with segmental porous baffles. Computational fluid dynamics (CFD) in combination with machine learning tools are utilized to investigate the thermo-hy ...

PERGAMON-ELSEVIER SCIENCE LTD2020