Publications associées à Human mesenchymal stromal cells improve survival and function of pancreatic islets by cell-to-cell contact

Publications associées (16)

Cellularization across eukaryotes: Conserved mechanisms and novel strategies

Many eukaryotes form multinucleated cells during their devel-opment. Some cells persist as such during their lifetime, others choose to cleave each nucleus individually using a specialized cytokinetic process known as cellularization. What is cellula-rizat ...

CURRENT BIOLOGY LTD2023

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion

Douglas Hanahan, Nadine Fournier, Mélanie Louise Tichet, Krisztian Homicsko, Agnieszka Alicja Chryplewicz, Mohammad Sadegh Saghafinia, Yuqing Xie, Dalya Ataca, Qiqun Zeng, Jeremy Gilles Louis Guillot, Simge Yücel

Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors. FM ...

American Association for the Advancement of Science2022

Microstructure estimation from diffusion-MRI: Compartmentalized models in permeable cellular tissue

Jean-Philippe Thiran, Gabriel Girard, Erick Jorge Canales Rodriguez, Jonathan Rafael Patino Lopez, Rémy Marc M Gardier, Juan Luis Villarreal Haro

Diffusion-weighted magnetic resonance imaging (DW-MRI) is used to characterize brain tissue microstructure employing tissue-specific biophysical models. A current limitation, however, is that most of the proposed models are based on the assumption of negli ...

2022

Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression

Douglas Hanahan, Krisztian Homicsko, Stephan Wullschleger, Iacovos Michael, Mohammad Sadegh Saghafinia

Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until now, the origin of aggressive MLP tumors has been obscure. Herein, using multi-omics ap ...

AMER ASSOC CANCER RESEARCH2021

ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD

Maurizio Molinari

ER-phagy, literally endoplasmic reticulum (ER)-eating, defines the constitutive or regulated clearance of ER portions within metazoan endolysosomes or yeast and plant vacuoles. The advent of electron microscopy led to the first observations of ER-phagy ove ...

Cell Press - Elsevier2021

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Cristina Ramona Cudalbu Moldovan, Lijing Xin, Mario Gaetano Lepore, Marta Lai

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain ...

2021

Visualizing intracellular nanostructures of living cells by nanoendoscopy-AFM

Marcos Penedo Garcia

Atomic force microscopy (AFM) is the only technique that allows label-free imaging of nanoscale biomolecular dynamics, playing a crucial role in solving biological questions that cannot be addressed by other major bioimaging tools (fluorescence or electron ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Variations of intracellular density during the cell cycle arise from tip-growth regulation in fission yeast

Emrah Bostan, Pascal Damian Odermatt

Intracellular density impacts the physical nature of the cytoplasm and can globally affect cellular processes, yet density regulation remains poorly understood. Here, using a new quantitative phase imaging method, we determined that dry-mass density in fis ...

ELIFE SCIENCES PUBLICATIONS LTD2021

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Manuele Piccolis

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome, lipidome, and genetic interactions of human leukemia cells exposed to palmitate. Pa ...

CELL PRESS2019

Human mesenchymal stromal cells improve survival and function of pancreatic iislets by cell-to-cell contact through N-cadherin

Sandrine Gerber, Jutta Christine Wandrey, Redouan Mahou, Solène Marcelle Françoise Marie Passemard, François Rémi Pierre Noverraz

Wiley-Blackwell2015

Survival of Free and Encapsulated Human and Rat Islet Xenografts Transplanted into the Mouse Bone Marrow

Jutta Christine Wandrey, Redouan Mahou

Bone marrow was recently proposed as an alternative and potentially immune-privileged site for pancreatic islet transplantation. The aim of the present study was to assess the survival and rejection mechanisms of free and encapsulated xenogeneic islets tra ...

Public Library of Science2014

Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers

Francesco Stellacci, Randy Patrick Carney

Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free e ...

American Chemical Society2013

COUP-TFII Controls Mouse Pancreatic beta-Cell Mass through GLP-1-beta-Catenin Signaling Pathways

Anne Grapin-Botton

Background: The control of the functional pancreatic beta-cell mass serves the key homeostatic function of releasing the right amount of insulin to keep blood sugar in the normal range. It is not fully understood though how beta-cell mass is determined. ...

2012

Multicolor Single Molecule Tracking of Stochastically Active Synthetic Dyes

Suliana Manley, Aleksandr Benke, Julia Gunzenhäuser

Single particle tracking can reveal dynamic information at the scale of single molecules in living cells but thus far has been limited either in the range of potential protein targets or in the quality and number of tracks attainable. We demonstrate a new ...

American Chemical Society2012

Targeting of multiple metabolites in neural cells monitored by using protein-based carbon nanotubes

Giovanni De Micheli, Sandro Carrara, Cristina Boero

Microdevices dedicated to monitor metabolite levels have recently enabled many applications in the field of cell analysis, to monitor cell growth and development of numerous cell lines. By combining the traditional technology used for electrochemical biose ...

2011

Measurement of the integral refractive index and dynamic cell morphometry of living cells with digital holographic microscopy

Pierre Magistretti, Pierre Marquet, Christian Depeursinge, Benjamin Rappaz, Etienne Cuche

We have developed a digital holographic microscope (DHM), in a transmission mode, adapted to the quantitative study of cellular dynamics. Living cells in culture are optically probed by measuring the phase shift they produce on the transmitted wave front. ...

2005