Impaired heart rate variability triangular index to identify clinically silent strokes in patients with atrial fibrillation

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While ventricular electromechanics is extensively studied in both physiological and pathological conditions, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are character ...

Hyperpolarization of 13C by dissolution dynamic nuclear polarization (dDNP) boosts the sensitivity of magnetic resonance spectroscopy (MRS), making possible the monitoring in vivo and in real time of the biochemical reactions of exogenously infused 13C-lab ...

The goal of this work is to investigate the ability of transfer learning (TL) and multitask learning (MTL) algorithms to predict tasks related to myocardial infarction (MI) in a small-data regime, leveraging a larger dataset of haemodynamic targets. The da ...

Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...

In this paper, we present a mathematical model able to simulate the cardiac function. We first describe the basic physical principles behind the mathematical equations, then we illustrate a few examples of application to problems of clinical relevance. ...

Background In factor XI (FXI) deficiency, bleeding cannot be predicted by routine analyses. Since FXI is involved in tissue factor (TF)-independent propagation loop of coagulation, we hypothesized that investigating the spatiotemporal separated phases of c ...

Arterial rupture in horses has been observed during exercise, after phenylephrine administration or during parturition (uterine artery). In human pathophysiological research, the use of computer models for studying arterial hemodynamics and understanding n ...

The monitoring of central hemodynamic parameters such as cardiac output (CO) and pulmonary artery pressure (PAP) is of paramount clinical importance to assess the health status of the cardiovascular system. However, their measurement requires the insertion ...

As part of the 2015 PhysioNet/CinC Challenge, this work aims at lowering the number of false alarms, which are a persistent concern in the intensive care unit. The multimodal database consists of 1250 life-threatening alarm recordings, each categorized as ...

The treatments for ischemic stroke can only be administered in a narrow time-window. However, the ischemia onset time is unknown in ~30% of stroke patients (wake-up strokes). The objective of this study was to determine whether MR spectra of ischemic brain ...

Stepwise catheter ablation (step-CA) can terminate long-standing persistent atrial fibrillation (LS-pAF) within the left atrium (LA) or may require additional right atrial (RA) ablation. Intracardiac organization indices such as AF cycle length (AFCL) have ...

It was recently shown that atrial fibrillation (AF) waves on chest lead V1 adequately reflect right atrial appendage (RAA) activity during long standing persistent AF (pers-AF). The contribution of the left atrial (LA) activity to chest leads AF waves, how ...

Background: Cerebral autoregulation (CA) is a protective mechanism which maintains the steadiness of the cerebral blood flow (CBF) through a broad range of systemic blood pressure (BP). Acute hypertension has been shown to reduce the cerebrovascular adapta ...

It was the aim of this study to investigate the long- term effects of reduced aortic compliance on cardiovascular hemodynamics and cardiac remodeling. ...

In this thesis we study ventricular-arterial coupling in rodents under the influence of arterial stiffening and myocardial infarction (MI), combination of the two considered as a novel cardiovascular research model for diseased hearts pumping against an ag ...

Impaired heart rate variability triangular index to identify clinically silent strokes in patients with atrial fibrillation

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A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

A polygenic risk score to predict sudden cardiac arrest in patients with cardiovascular disease

Influence of DNP Polarizing Agents on Biochemical Processes: TEMPOL in Transient Ischemic Stroke

Can Knowledge Transfer Techniques Compensate for the Limited Myocardial Infarction Data by Leveraging Haemodynamics? An in silico Study

Assessment Of Stiffness Of Large To Small Arteries In Multi-Stage Renal Disease: A Numerical Study

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

A mathematical model of the human heart

Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy

A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions

Non-invasive hemodynamic monitoring by electrical impedance tomography

A Multimodal Approach to Reduce False Arrhythmia Alarms in the Intensive Care Unit

Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia

Measures of Right Atrial Organization as a Mean to Select Candidates for Sinus Rhythm Restoration by Catheter Ablation

Contribution of Left and Right Atrial Appendage Activities to ECG Fibrillation Waves

The Effect of Valsartan versus Non-RAAS Treatment on Autoregulation of Cerebral Blood Flow

Left ventricular hypertrophy induced by reduced aortic compliance

Effects of a stiffened arterial tree on ventricular-arterial coupling in healthy and diseased hearts