Publications associées à Synthesis of diphenoxyadamantane alkylamines with pharmacological interest

Publications associées (5)

Deconvolution of ex-vivo drug screening data and bulk tissue expression predicts the abundance and viability of cancer cell subpopulations

Ex-vivo drug sensitivity screening (DSS) allows the prediction of cancer treatment effectiveness in a personalized fashion. However, it only provides a readout on mixtures of cells, potentially occulting important information on clinically relevant cell su ...

EPFL2023

MiMiCPy: An Efficient Toolkit for MiMiC-Based QM/MM Simulations

Ursula Röthlisberger, Sophia Kathryn Johnson, Andrea Levy

MiMiC is a highly flexible, extremely scalable multiscale modeling framework. It couples the CPMD (quantum mechanics, QM) and GROMACS (molecular mechanics, MM) codes. The code requires preparing separate input files for the two programs with a selection of ...

AMER CHEMICAL SOC2023

High Sensitivity Detection of a Solubility Limiting Surface Transformation of Drug Particles by DNP SENS

David Lyndon Emsley, Arthur César Pinon, Jasmine Viger-Gravel

We investigate the presence of a surface species for the active pharmaceutical ingredient (API) AZD9496 with dynamic nuclear polarization surface enhanced nuclear spectroscopy (DNP SENS). We show that using DNP we can elucidate the presence of an amorphous ...

2021

Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1)

Pierre Vogel, Florence Pojer, Somi Reddy Majjigapu, Aline Emma Christine Reynaud

Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-limiting step in the kynurenine pathway of tryptophan metabolism, which is involved in immunity, neuronal function, and aging. Its implication in pathologies such as cancer and neurodegenerative disea ...

AMER CHEMICAL SOC2019

Skin lightening products' violations in Europe: An analysis of the rapid alert system for dangerous non-food products 2005-2018

Florentino Luciano Caetano Dos Santos

Background: Skin lightening products containing dangerous levels of chemicals pose a serious health concern for consumers. However, to date, the extent of these products in Europe has not been extensively studied. The aim of this study was to determine whe ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2019