Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

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Epidural electrical stimulation of the spinal cord elicits motor responses by recruiting large sensory afferents in the posterior roots. Divergence of excitatory inputs provided by these fibers generates a variety of shapes, latencies and amplitudes in the ...

We propose a statistically optimal approach to construct data-driven decisions for stochastic optimization problems. Fundamentally, a data-driven decision is simply a function that maps the available training data to a feasible action. It can always be exp ...

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...

Well-validated chemical probes enable testing of biological hypotheses, investigation of target tractability and translatability to the clinical phase. Consequently, these important tool compounds play a key role in the drug discovery process. Moreover, th ...

Objective Segmented deep brain stimulation leads in the subthalamic nucleus have shown to increase therapeutic window using directional stimulation. However, it is not fully understood how these segmented leads with reduced electrode size modify the volume ...

Here we demonstrate the suitability of a local mutual information measure for estimating the temporal dynamics of cross-frequency coupling (CFC) in brain electrophysiological signals. In CFC, concurrent activity streams in different frequency ranges intera ...

Purpose of ReviewData science is an exploding trans-disciplinary field that aims to harness the power of data to gain information or insights on researcher-defined topics of interest. In this paper, we review how data science can help advance environmental ...

Cancer immunotherapy with immune checkpoint inhibitors (CPIs) and interleukin-2 (IL-2) has demonstrated clinical efficacy but is frequently accompanied with severe adverse events caused by excessive and systemic immune system activation. Here, we addressed ...

Lithium represents the main drug for the treatment of Bipolar Disorder (BD) as it acts as a mood stabilizer. However, because of its narrow therapeutic window, psychiatric patients are obliged to frequent tests in hospital to control their lithium blood co ...

Deletion is a core facet of Online Social Networks (OSNs). For users, deletion is a tool to remove what they have shared and control their data. For OSNs, robust deletion is both an obligation to their users and a risk when developer mistakes inevitably oc ...

In this study, a unified framework to estimate different microstructure indices from diffusion MRI and multi-echo T2 (MET2) data was proposed.The new methodology takes into account the common and complementary information provided by both modalities. While ...

Adaptive data analysis is known to introduce bias in reported measurements. Russo and Zou [1] recently introduced an information-theoretic framework to study this problem. Herein, this framework is adopted and new dependence measures are introduced to boun ...

Helminth infection represents a major health problem causing approximately 5 million disability-adjusted life years worldwide. Concerns that repeated anti-helminthic treatment may lead to drug resistance render it important that vaccines are developed but ...

Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

Chattez avec Graph Search

Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates

A Pareto Dominance Principle for Data-Driven Optimization

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Design and validation of bioorthogonal probes for cellular disease models

Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus

Measuring transient phase-amplitude coupling using local mutual information

Data Science in Environmental Health Research

Targeted antibody and cytokine cancer immunotherapies through collagen affinity

A wearable electrochemical sensing system for non-invasive monitoring of lithium drug in bipolar disorder

DELF: Safeguarding deletion correctness in Online Social Networks

Unified multi-modal characterization of microstructural parameters of brain tissue using diffusion MRI and multi-echo T2 data

Computable Bounds on the Exploration Bias

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae